Cell resilience in species life spans: a link to inflammation?
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Summary: Species differences in life span have been attributed to cellular survival during various stressors, designated here as ‘cell resilience’. In primary fibroblast cultures, cell resilience during exposure to free radicals, hypoglycemia, hyperthermia, and various toxins has shown generally consistent correlations with the species characteristic life spans of birds and mammals. However, the mechanistic links of cell resilience in fibroblast cultures to different species life spans are poorly understood. We propose that certain experimental stressors are relevant to somatic damage in vivo during inflammatory responses of innate immunity, particularly, resistance to reactive oxygen species (ROS), low glucose, and hyperthermia. According to this hypothesis, somatic cell resilience determines species differences in longevity during repeated infections and traumatic injuries in the natural environment. Infections and injury expose local fibroblasts and other cells to ROS generated by macrophages and to local temperature elevations. Systemically, acute phase immune reactions cause hypoglycemia and hyperthermia. We propose that cell resilience to somatic stressors incurred in inflammation is important in the evolution of longevity and that longer‐lived species are specifically more resistant to immune‐related stressors. This hypothesis further specifies Kirkwood’s disposable soma theory. We suggest expanding the battery of stressors and markers used for comparative studies to additional cell types and additional parameters relevant to host defense and to their ecological specificities.
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Inflammaging is a hallmark of nearly every major age-related disease and phenotype and a defining pathological feature of aging tissues across multiple species.
“Inflammaging is a hallmark of virtually every major age-related disease and phenotype and has been shown to be a defining pathological characteristic of aging tissues across multiple species [5].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [5]
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On the immunological theory of aging
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Siglec receptors impact mammalian lifespan by modulating oxidative stress
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Immune Heterogeneity in Neuroinflammation: Dendritic Cells in the Brain
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Contemporaneous Social Environment and the Architecture of Late-Life Gene Expression Profiles
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A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans
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High-throughput and label-free isolation of senescent murine mesenchymal stem cells
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- Authors
- Finch, C. E., Morgan, T. E., Longo, V. D., & De Magalhaes, J. P.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Finch, Caleb E.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2010-07-21
- Volume
- 9
- Issue
- 4
- Pages
- 519-526
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC2952360
- OpenAlex
- W2098022090
- Cited by
- 29
- References
- 101
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 2 · 2012: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ellison Medical Foundation
- Biotechnology and Biological Sciences Research Council (BB/G024774/1)
- National Institute on Aging (AG026572, T32AG000093, AG20642, R01AG020642, AG025135, R01AG025135, P01AG026572)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- inflammation, reactive oxygen species, hypoglycemia, hyperthermia, fibroblasts, disposable soma theory, innate immunity, macrophages, acute phase response, stress tolerance, comparative aging
- MeSH terms
- Acute-Phase Reaction, Animals, Cell Survival, DNA Damage, Fibroblasts, Immunity, Innate, Inflammation, Longevity, Models, Biological, Phylogeny, Species Specificity, Genome, Cell Death, Oxidative Stress
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