When Less Is More: Gene Loss as an Engine of Evolutionary Change
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The "less is more" principle likely applies to the loss of genes involved in insulin signaling (FAM3B and FFAR3) and renal function (SLC22A12, SLC22A6, SLC2A9, and RHBG) in fruit bats.
“This “less is more” principle56 likely applies to the loss of genes involved in insulin signaling (FAM3B and FFAR3) and renal function (SLC22A12, SLC22A6, SLC2A9, and RHBG) in fruit bats”
From A genomics approach reveals insights into the importance of gene losses for mammalian adaptations (2018) · cites this paper as [56]
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- Authors
- Olson, M. V.
- Affiliations
- University of Washington (US)
- Corresponding author
- Olson, Maynard V.
- ORCID
- Olson, Maynard V.
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 64
- Issue
- 1
- Pages
- 18-23
- ISSN
- 0002-9297 (ISSN-L)
- PMC
- PMC1377697
- OpenAlex
- W2066036014
- Cited by
- 437
- References
- 2
- Citations by year
- 2026: 30 · 2025: 15 · 2024: 19 · 2023: 16 · 2022: 22 · 2021: 23 · 2020: 17 · 2019: 25 · 2018: 11 · 2017: 17 · 2016: 22 · 2015: 16 · 2014: 17 · 2013: 13 · 2012: 20
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The American Journal of Human Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Cultural Studies › Language and cultural evolution
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- gene loss, evolutionary change, beneficial mutations, purging of deleterious mutations, natural selection, human evolution, natural populations
- MeSH terms
- Animals, Humans, Gene Deletion, Evolution, Molecular
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