Loss of chromatic sensitivity in AMD and diabetes: a comparative study
Abstract
Background: Abnormalities in rod and cone photoreceptor morphology have been reported in normal aging retinas in the absence of known pathology and have been taken as an indicator of susceptibility to retinal disease. Some loss of visual performance may therefore precede retinal structural changes that can be detected reliably using conventional fundus imaging techniques. Red/green (RG) and yellow/blue (YB) colour discrimination thresholds are sensitive measures of normal retinal function and poor YB discrimination is often taken as an indicator of retinal disease, though it is generally acknowledged that RG loss is also present in most cases of acquired deficiency. Although structural changes in age‐related macular degeneration (AMD) and diabetes share some similarities, significant differences remain and this may result in different patterns of RG and YB loss. Aim: The aim of this study was to quantify and compare the severity of RG and YB loss of chromatic sensitivity in patients with AMD and diabetes. Methods: Patients with varying severity of AMD and diabetes and normal subjects of similar age were recruited for the study. RG and YB colour detection thresholds were measured in the two groups of patients and the control group, using the Colour Assessment and Diagnosis (CAD) test. Results: Each AMD subject investigated showed significant, but unequal loss of YB and RG chromatic sensitivity, with YB discrimination showing the greatest loss. Diabetic subjects also exhibited reduced chromatic sensitivity, but with almost equal and highly correlated RG and YB thresholds ( R 2 = 0.99). The severity of colour vision loss measured with the CAD test also correlates well with a clinical classification index of disease progression in AMD, and with the level of hyperglycaemic control in diabetes. Conclusions: These findings suggest that accurate measurements of RG and YB colour thresholds can provide a sensitive measure of functional change in diseases of the retina with patterns of loss that differ significantly in AMD and diabetes.
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Macular degeneration causes chromatic sensitivity.
“An adaptable color scheme could also be provided (e.g., more/less contrasting colors and changing the brightness and tone of the screen) as macular degeneration causes chromatic sensitivity [61].”
From Participatory Design, Development, and Testing of Assistive Health Robots with Older Adults: An International Four-year Project (2022) · cites this paper as [61]
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Colour Vision Changes across Lifespan: Insights from FM100 and CAD Tests
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Self-citationThe Calcium Signalling Profile of the Inner Blood–Retinal Barrier in Diabetic Retinopathy
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Color Vision in Clinical Practice
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- Authors
- O’Neill‐Biba, M., Sivaprasad, S., Rodriguez‐Carmona, M., Wolf, J. E., & Barbur, J. L.
- Affiliations
- King's College Hospital (GB)
- City, University of London (GB)
- Venue
- Ophthalmic and Physiological Optics
- Published
- 2010-08-25
- Volume
- 30
- Issue
- 5
- Pages
- 705-716
- ISSN
- 0275-5408 (ISSN-L)
- 1475-1313
- OpenAlex
- W1937931208
- Cited by
- 74
- References
- 65
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 11 · 2013: 1 · 2012: 6
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ophthalmic and Physiological Optics (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- color sensitivity, color vision loss, age-related macular degeneration, diabetic retinopathy, retinal function, disease severity
- MeSH terms
- Adult, Aged, Aged, 80 and over, Color Vision Defects, Color Perception Tests, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Retinopathy, Female, Humans, Macular Degeneration, Male, Middle Aged, Sensory Thresholds, Severity of Illness Index, Visual Acuity, Diabetes Complications, Young Adult
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