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Cited by 73Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyElectrolyte and hormonal disorders

THE FATE OF OXYTOCIN IN MALE AND FEMALE RATS

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GINSBURG, M., SMITH, M. W.·1959·British Journal of Pharmacology and Chemotherapy
DOI 10.1111/j.1476-5381.1959.tb00252.xPMC PMC1481739
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Abstract

A method for quantitative extraction of oxytocin from blood is described. The disappearance of injected oxytocin from the circulation in rats was shown to depend upon its uptake in the kidneys and in organs of the splanchnic vascular area. In lactating rats there was uptake by an additional organ or tissue, probably the mammary gland. In animals without kidneys or lactating mammary glands and with no circulation in the splanchnic area oxytocin was distributed into a volume greater than the extracellular fluid volume, and after equilibration the concentration in plasma did not change significantly. During severe haemorrhage increased amounts of antidiuretic activity were detected in blood when there was no significant increase in oxytocic activity.

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  • Practical bioassays for oxytocin were less sensitive than antidiuretic assays.

    “Antidiuretic assays benefitted from the extreme sensitivity of the urine concentrating mechanisms of the kidney, but practical bioassays for oxytocin were less sensitive.”

    From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [49]

  • Bioassays using the nonpregnant rat uterus and mammary gland could generally detect only oxytocin concentrations above 25 μU/ml (42 pg/ml).

    “Bioassays using the nonpregnant rat uterus 49 and mammary gland bioassays 42 could generally detect only concentrations above 25 μU/ml (42 pg/ml).”

    From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [49]

  • Ultrafiltration of plasma indicated that approximately 30% of similarly infused vasopressin was bound to large molecules, whereas there was no apparent binding of oxytocin; in vitro oxytocin bioactivity was stable, with only approximately 20% lost after 24 h at 37 °C.

    “Ultrafiltration of the plasma indicated that, whereas approximately 30% of similarly infused vasopressin was bound to large molecules, there was no apparent binding of oxytocin. In vitro, oxytocin bioactivity was stable, as found in rats 49; only approximately 20% was lost after 24 h at 37 °C.”

    From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [49]

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Research works printed but not linked: 3

  1. Elgee, N. J., and Williams, R. H. (1954). Proc. Soc. exp. Biol. (N.Y.), 87, 352.
  2. Richards, J. B., and Sayers, G. (1951). Proc. Soc. exp. Biol. (N. Y.), 77, 87.
  3. 14765381a, 1959, 3, Downloaded from https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.1959.tb00252.x by Mount Vernon Nazarene University, Wiley Online Library on [23/06/2026]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI

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Authors
GINSBURG, M., & SMITH, M. W.
Affiliations
University of Bristol (GB)
ORCID
GINSBURG, M.
Venue
British Journal of Pharmacology and Chemotherapy
Publisher
Wiley
Published
1959-09
Volume
14
Issue
3
Pages
327-333
ISSN
0366-0826 (ISSN-L)
DOI
10.1111/j.1476-5381.1959.tb00252.x
PMC
PMC1481739
OpenAlex
W2026854044
Cited by
73
References
26
Citations by year
2026: 1 · 2025: 1 · 2022: 2 · 2021: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1
FWCI
6.80
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 19315 d)
Locations
  • British Journal of Pharmacology and Chemotherapy (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
Keywords
oxytocin, renal uptake, splanchnic circulation, mammary gland, lactation, plasma distribution, extracellular volume, hemorrhage, antidiuretic activity, oxytocic activity, rats
MeSH terms
Animals, Female, Humans, Lactation, Male, Oxytocin, Rats

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