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SOME QUANTITATIVE USES OF DRUG ANTAGONISTS
Open accessAbstract
Various applications of p A x measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of p A x measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine‐atropine, histamine‐atropine and acetylcholine‐cinchonidine. A new measure, p A h, is introduced to express the activity of unsurmountable antagonists.
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Citations
Cited by
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Black, J. W., & Leff, P. (1983) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1983.0093 · Cited by 951
Foster, A. C., & Wong, E. H. F. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb10295.x · Cited by 448
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McCarthy, D. A., & Dale, M. M. (1988) · Sports Medicine · doi:10.2165/00007256-198806060-00002 · Cited by 370
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Putney, J. W., Weiss, S. J., Van De Walle, C. M., & Haddas, R. A. (1980) · Nature · doi:10.1038/284345a0 · Cited by 329
Dumont, F. J., Staruch, M. J., Koprak, S. L., Siekierka, J. J., Lin, C. S., Harrison, R., Sewell, T., Kindt, V. M., Beattie, T. R., & Wyvratt, M. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.3.751 · Cited by 250
Metadata
- Authors
- ARUNLAKSHANA, O., & SCHILD, H. O.
- Venue
- British Journal of Pharmacology and Chemotherapy
- Publisher
- Wiley
- Published
- 1959-03
- Volume
- 14
- Issue
- 1
- Pages
- 48-58
- ISSN
- 0366-0826 (ISSN-L)
- OpenAlex
- W2057971042
- Cited by
- 3,938
- References
- 0
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- ARUNLAKSHANA, O., & SCHILD, H. O. (1959). SOME QUANTITATIVE USES OF DRUG ANTAGONISTS. British Journal of Pharmacology and Chemotherapy. https://doi.org/10.1111/j.1476-5381.1959.tb00928.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
