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Cited by 370Exercise and Physiological ResponsesCardiovascular and exercise physiologySports Performance and Training

The Leucocytosis of Exercise: A Review and Model

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McCarthy, D.A., Dale, M.M.·1988·Sports Medicine
DOI 10.2165/00007256-198806060-00002
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Abstract

Exercise is known to induce an immediate leucocytosis, the magnitude of which is related, in most instances, to the intensity and duration of the work. On finishing exercise, however, the leucocyte count may change in any one of several different ways. The pattern of postexercise changes in the leucocyte count is determined mainly by the time which has elapsed since beginning exercise, rather than the work intensity or the total work done, if, for example, exercise has been intermittent. Consideration of, firstly, the circumstances under which the plasma concentrations of catecholamines and cortisol have been found separately to correlate with the leucocyte count at the finish of exercise, and, secondly, the effects on the leucocyte count of exogenous administration of these substances has led us to develop a model which can satisfactorily account for all of the principal changes in the leucocyte count that have been noted during and after exercise. It is proposed that catecholamines produced during exercise act to increase the ratio of circulating to non-circulating leucocytes, while cortisol acts, by a mechanism which involves a time lag, to increase the total number of leucocytes in the vascular compartment. Examination of previously published reports shows that many contain results which support this model. Using the model as a basis, some predictions are made that can be tested experimentally, and some experiments are suggested which should help elucidate the mode of action of catecholamines and cortisol.

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  • During exercise, lymphocytes and neutrophils are mobilized to the blood.

    “During exercise, lymphocytes and neutrophils are mobilized to the blood.”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [202]

  • Following long-duration exercise of high intensity, the concentration of lymphocytes falls below pre-exercise values whereas the neutrophil number continues to increase.

    “Following long-duration exercise of high intensity, the concentration of lymphocytes falls below pre-exercise values whereas the neutrophil number continues to increase (202, 203).”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [202]

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Authors
McCarthy, D. A., & Dale, M. M.
Affiliations
Queen Mary University of London (GB)
ORCID
Dale, M.M.
Venue
Sports Medicine
Publisher
Springer Science and Business Media LLC
Published
1988-12
Volume
6
Issue
6
Pages
333-363
ISSN
0112-1642 (ISSN-L)
DOI
10.2165/00007256-198806060-00002
OpenAlex
W1982775333
Cited by
370
References
152
Citations by year
2026: 5 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 17 · 2019: 5 · 2018: 10 · 2017: 8 · 2016: 16 · 2015: 11 · 2014: 13 · 2013: 11 · 2012: 11
FWCI
4.79
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Sports Medicine (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
catecholamines, cortisol, leukocyte mobilization, exercise intensity and duration, intermittent exercise
MeSH terms
Adolescent, Adult, Aged, Catecholamines, Child, Female, Humans, Hydrocortisone, Leukocyte Count, Leukocytosis, Male, Middle Aged, Exercise

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