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Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l‐arginine transporter
Open accessAbstract
The effects of inhibitors of nitric oxide (NO) synthase and other cationic amino acids on unidirectional l‐arginine transport were studied in porcine aortic endothelial cells cultured in microwell plates or perfused in microcarrier columns.l‐Homoarginine,l‐lysine and l‐ornithine inhibited transport of l‐arginine. The NO synthase inhibitors N G‐monomethyl‐l‐arginine and N G‐iminoethyl‐l‐ornithine also reduced l‐arginine uptake, whereas N G‐nitro‐l‐arginine and its methyl‐ester had no inhibitory effect. The ability to modulate selectively endothelial cell l‐arginine transport or NO synthase activity will allow further characterization of the arginine transporter and its role in regulating NO biosynthesis.
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Citations
Cited by
Arginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Nitric oxide synthases in mammals
Knowles, R. G., & Moncada, S. (1994) · Biochemical Journal · doi:10.1042/bj2980249 · Cited by 2,752
Self-citationNitric oxide and lung disease.
Barnes, P. J., & Belvisi, M. G. (1993) · Thorax · doi:10.1136/thx.48.10.1034 · Cited by 438
Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells
Mann, G. E., Yudilevich, D. L., & Sobrevia, L. (2003) · Physiological Reviews · doi:10.1152/physrev.00022.2002 · Cited by 430
Self-citationModulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., & Salvemini, D. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.1 · Cited by 357
Metadata
- Authors
- Bogle, R. G., Moncada, S., Pearson, J. D., & Mann, G. E.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1992-04
- Volume
- 105
- Issue
- 4
- Pages
- 768-770
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2010164098
- Cited by
- 169
- References
- 0
- FWCI
- 11.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l‐arginine transporter. https://app.cochat.ai/papers/10.1111/j.1476-5381.1992.tb09053.x
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- Bogle, R. G., Moncada, S., Pearson, J. D., & Mann, G. E. (1992). Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l‐arginine transporter. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1992.tb09053.x
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