The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
Open accessAbstract
DNA/cationic lipid (lipoplexes), DNA/cationic polymer (polyplexes) and DNA/cationic polymer/cationic lipid (lipopolyplexes) electrostatic complexes are proposed as non‐viral nucleic acids delivery systems. These DNA‐nanoparticles are taken up by the cells through endocytosis processes, but the low capacity of DNA to escape from endosomes is regarded as the major limitations of their transfection efficiency. Here, we present a current report on a particular class of carriers including the polymers, peptides and lipids, which is based on the exploitation of the imidazole ring as an endosome destabilization device to favour the nucleic acids delivery in the cytosol. The imidazole ring of histidine is a weak base that has the ability to acquire a cationic charge when the pH of the environment drops bellow 6. As it has been demonstrated for poly(histidine), this phenomena can induce membrane fusion and/or membrane permeation in an acidic medium. Moreover, the accumulation of histidine residues inside acidic vesicles can induce a proton sponge effect, which increases their osmolarity and their swelling. The proof of concept has been shown with polylysine partially substituted with histidine residues that has caused a dramatic increase by 3–4.5 orders of magnitude of the transfection efficiency of DNA/polylysine polyplexes. Then, several histidine‐rich polymers and peptides as well as lipids with imidazole, imidazolinium or imidazolium polar head have been reported to be efficient carriers to deliver nucleic acids including genes, mRNA or SiRNA in vitro and in vivo. More remarkable, histidylated carriers are often weakly cytotoxic, making them promising chemical vectors for nucleic acids delivery. This article is part of a themed section on Vector Design and Drug Delivery. For a list of all articles in this section see the end of this paper, or visit: http://www3.interscience.wiley.com/journal/121548564/issueyear?year=2009
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1 retracted
RETRACTED: Imidazolyl-PEI modified nanoparticles for enhanced gene delivery
Swami, A., Aggarwal, A., Pathak, A., Patnaik, S., Kumar, P., Singh, Y. P., & Gupta, K. C. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.11.033 · Cited by 70
RetractedBoussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., & Behr, J. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,247
Bartlett, D. W., Su, H., Hildebrandt, I. J., Weber, W. A., & Davis, M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707461104 · Cited by 803
The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer
Farhood, H., Serbina, N., & Huang, L. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)80016-9 · Cited by 798
Tat peptide-mediated cellular delivery: back to basics
BROOKS, H., LEBLEU, B., & VIVES, E. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.001 · Cited by 667
Wagner, E., Plank, C., Zatloukal, K., Cotten, M., & Birnstiel, M. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.7934 · Cited by 658
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Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini
Putnam, D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.031577698 · Cited by 510
Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes
Midoux, P., & Monsigny, M. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801070 · Cited by 501
Self-citationHeidel, J. D., Yu, Z., Liu, J. Y.-C., Rele, S. M., Liang, Y., Zeidan, R. K., Kornbrust, D. J., & Davis, M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701458104 · Cited by 382
Cited by
Base editing: precision chemistry on the genome and transcriptome of living cells
Rees, H. A., & Liu, D. R. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0059-1 · Cited by 1,675
Zuris, J. A., Thompson, D. B., Shu, Y., Guilinger, J. P., Bessen, J. L., Hu, J. H., Maeder, M. L., Joung, J. K., Chen, Z.-Y., & Liu, D. R. (2015) · Nature Biotechnology · doi:10.1038/nbt.3081 · Cited by 1,460
pH-Sensitive nano-systems for drug delivery in cancer therapy
Liu, J., Huang, Y., Kumar, A., Tan, A., Jin, S., Mozhi, A., & Liang, X.-J. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.11.009 · Cited by 1,121
Rees, H. A., Komor, A. C., Yeh, W.-H., Caetano-Lopes, J., Warman, M., Edge, A. S. B., & Liu, D. R. (2017) · Nature Communications · doi:10.1038/ncomms15790 · Cited by 412
The great escape: how cationic polyplexes overcome the endosomal barrier
Bus, T., Traeger, A., & Schubert, U. S. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00967h · Cited by 409
Metadata
- Authors
- Midoux, P., Pichon, C., Yaouanc, J., & Jaffrès, P.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2009-04-28
- Volume
- 157
- Issue
- 2
- Pages
- 166-178
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1577071491
- Cited by
- 548
- References
- 77
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Midoux, P., Pichon, C., Yaouanc, J., & Jaffrès, P. (2009). Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.2009.00288.x
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