Base editing: precision chemistry on the genome and transcriptome of living cells

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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Genome engineering using the CRISPR-Cas9 system

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RNA-Guided Human Genome Engineering via Cas9

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Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

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The new frontier of genome engineering with CRISPR-Cas9

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Development and Applications of CRISPR-Cas9 for Genome Engineering

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Instability and decay of the primary structure of DNA

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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

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Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

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Coming of age: ten years of next-generation sequencing technologies

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Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

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ClinVar: public archive of relationships among sequence variation and human phenotype

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Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

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ClinVar: public archive of interpretations of clinically relevant variants

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In vivo genome editing using Staphylococcus aureus Cas9

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High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects

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Progress and problems with the use of viral vectors for gene therapy

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The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

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Crystal structure of Cas9 in complex with guide RNA and target DNA

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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

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Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

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RNA-programmed genome editing in human cells

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Identification of genes that are associated with DNA repeats in prokaryotes

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A general method for the covalent labeling of fusion proteins with small molecules in vivo

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Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

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Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

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Construction of Biologically Functional Bacterial Plasmids In Vitro

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RNA editing with CRISPR-Cas13

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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

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CRISPResso2 provides accurate and rapid genome editing sequence analysis

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Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

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Engineered CRISPR-Cas9 nucleases with altered PAM specificities

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A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging

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Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

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Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

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Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

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Therapeutic genome editing: prospects and challenges

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Functions and Regulation of RNA Editing by ADAR Deaminases

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RNA Editing by Adenosine Deaminases That Act on RNA

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CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

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Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

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In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

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Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

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Engineered CRISPR-Cas9 nuclease with expanded targeting space

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CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

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p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

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Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

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Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

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Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion

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APOBEC3B is an enzymatic source of mutation in breast cancer

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Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion

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Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

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Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

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Widespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome

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Targeted Mutagenesis, Precise Gene Editing, and Site-Specific Gene Insertion in Maize Using Cas9 and Guide RNA

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In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

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Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

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Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

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RNA Editing Enzyme APOBEC1 and Some of Its Homologs Can Act as DNA Mutators

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A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genesPreprint

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Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

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Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

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Directed evolution of CRISPR-Cas9 to increase its specificity

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Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion

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Uracil in DNA – occurrence, consequences and repair

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Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells

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Precision genome engineering and agriculture: opportunities and regulatory challenges

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Analyzing CRISPR genome-editing experiments with CRISPResso

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Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy

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Constitutive Expression of AID Leads to Tumorigenesis

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Progress and prospects in plant genome editing

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An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

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Base editing with a Cpf1–cytidine deaminase fusion

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Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

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Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

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Expanding the Biologist’s Toolkit with CRISPR-Cas9

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Highly efficient RNA-guided base editing in mouse embryos

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CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons

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Introduction of Double-Strand Breaks into the Genome of Mouse Cells by Expression of a Rare-Cutting Endonuclease

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5 DNA Breakage and Repair

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