The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.
Open accessAbstract
Complexes containing plasmid DNA, transferrin-polylysine conjugates, and polylysine-conjugated peptides derived from the N-terminal sequence of the influenza virus hemagglutinin subunit HA-2 have been used for the transfer of luciferase or beta-galactosidase marker genes to K562 cells, HeLa cells, and BNL CL.2 hepatocytes. These DNA complexes mimic the entry of viruses into cells, as they contain functions for (i) the packaging of the nucleic acid with polylysine, (ii) the attachment to the cell and receptor-mediated endocytosis with transferrin as a ligand, and (iii) the release from endosomes by using membrane-disrupting influenza peptides. The presence of these influenza peptide conjugates in the DNA complexes renders the complexes active in membrane disruption in a liposome leakage assay and results in a substantial augmentation of the transferrin-polylysine-mediated gene transfer.
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Cites
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Self-citationWagner, E., Cotten, M., Foisner, R., & Birnstiel, M. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4255 · Cited by 484
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Endosomal escape pathways for delivery of biologicals
Varkouhi, A. K., Scholte, M., Storm, G., & Haisma, H. J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.004 · Cited by 1,561
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Metadata
- Authors
- Wagner, E., Plank, C., Zatloukal, K., Cotten, M., & Birnstiel, M. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-09
- Volume
- 89
- Issue
- 17
- Pages
- 7934-7938
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2023532191
- Cited by
- 658
- References
- 27
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. https://app.cochat.ai/papers/10.1073/pnas.89.17.7934
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- Wagner, E., Plank, C., Zatloukal, K., Cotten, M., & Birnstiel, M. L. (1992). Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.17.7934
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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