The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Severity of liver disease does not predict osteopenia or low bone mineral density in primary sclerosing cholangitis
Open accessAbstract
Background: The association between metabolic bone disease and cholestatic liver disease has been poorly characterized. To date a single institution has published data suggesting that in primary sclerosing cholangitis (PSC), advanced liver disease predicts advanced bone disease. Aim: To determine the association between the severity of liver disease and bone mineral density (BMD) in PSC patients. Methods: We identified 30 PSC patients who had undergone dual energy X‐ray absorptiometry (DXA) scan. We compared lumbar spine DXA scores between patients with more and less advanced liver disease. Results: Nine patients were osteopenic (30%), and one patient was osteoporotic. Five patients were female (17%), and none was postmenopausal. BMD was not different between patients listed and not listed for liver transplantation (P=0.49) or between patients with and without hepatic decompensation (P=0.63). Model for end‐stage liver disease (MELD) score (P=0.99) and the modified Mayo risk score (P=0.25) did not predict BMD. Conclusions: Our study is the first to suggest that low bone density cannot be predicted by the severity of liver disease in PSC. Perhaps other known risk factors for osteoporosis will be important predictors of abnormal bone density in this patient population.
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Stage of liver disease does not appear to be a major risk factor for osteoporosis in PSC.
“Stage of liver disease does not appear to be a major risk factor, 140,142 underlining the need to search for bone disease even in early-stage disease.”
From EASL Clinical Practice Guidelines on sclerosing cholangitis (2022) · cites this paper as [142]
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EASL Clinical Practice Guidelines on sclerosing cholangitis
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Metadata
- Authors
- Campbell, M. S., Lichtenstein, G. R., Rhim, A. D., Pazianas, M., & Faust, T.
- Affiliations
- Hospital of the University of Pennsylvania (US)
- Corresponding author
- Faust, Thomas
- Venue
- Liver International
- Publisher
- Wiley
- Published
- 2005-03-17
- Volume
- 25
- Issue
- 2
- Pages
- 311-316
- ISSN
- 0106-9543 (ISSN-L)
- 1478-3223
- 1478-3231
- OpenAlex
- W1991562388
- Cited by
- 34
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 1
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Liver International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- primary sclerosing cholangitis, osteopenia, metabolic bone disease, cholestatic liver disease, liver disease severity, MELD score, hepatic decompensation, liver transplantation, osteoporosis risk factors
- MeSH terms
- Adult, Analysis of Variance, Bone Diseases, Metabolic, Female, Humans, Liver Diseases, Male, Middle Aged, Osteoporosis, Predictive Value of Tests, Probability, Prognosis, Sensitivity and Specificity, Severity of Illness Index, Cholangitis, Sclerosing, Absorptiometry, Photon, Bone Density, Incidence, Linear Models, Age Distribution, Sex Distribution, Risk Assessment
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