The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Role of Kupffer cells in host defense and liver disease
Abstract
Abstract: Kupffer cells (KC) constitute 80–90% of the tissue macrophages present in the body. They reside within the lumen of the liver sinusoids, and are therefore constantly exposed to gut‐derived bacteria, microbial debris and bacterial endotoxins, known to activate macrophages. Upon activation KC release various products, including cytokines, prostanoides, nitric oxide and reactive oxygen species. These factors regulate the phenotype of KC themselves, and the phenotypes of neighboring cells, such as hepatocytes, stellate cells, endothelial cells and other immune cells that traffic through the liver. Therefore, KC are intimately involved in the liver's response to infection, toxins, ischemia, resection and other stresses. This review summarizes established basic concepts of KC function as well as their role in the pathogenesis of various liver diseases.
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Cites
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Cited by
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
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Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
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Liver immunology and its role in inflammation and homeostasis
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Immune surveillance by the liver
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Metadata
- Authors
- Bilzer, M., Roggel, F., & Gerbes, A. L.
- Venue
- Liver International
- Publisher
- Wiley
- Published
- 2006-11-08
- Volume
- 26
- Issue
- 10
- Pages
- 1175-1186
- ISSN
- 0106-9543 (ISSN-L)
- 1478-3223
- 1478-3231
- OpenAlex
- W2009523307
- Cited by
- 856
- References
- 13
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- closed
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