Cited by 379Hepatitis C virus researchDrug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

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The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients: Mitoquinone and liver damage

Gane, Edward J., Weilert, Frank, Orr, David W., Keogh, Geraldine F., Gibson, Michael, Lockhart, Michelle M., Frampton, Christopher M., Taylor, Kenneth M., Smith, Robin A. J., Murphy, Michael P.·2010·Liver International

DOI 10.1111/j.1478-3231.2010.02250.x

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Abstract

BACKGROUND: Increased oxidative stress and subsequent mitochondrial damage are important pathways for liver damage in chronic hepatitis C virus (HCV) infection; consequently, therapies that decrease mitochondrial oxidative damage may improve outcome. The mitochondria-targeted anti-oxidant mitoquinone combines a potent anti-oxidant with a lipophilic cation that causes it to accumulate several-hundred fold within mitochondria in vivo. AIMS: In this phase II study, we investigated the effect of oral mitoquinone on serum aminotransferases and HCV RNA levels in HCV-infected patients. METHODS: Thirty HCV patients who were either non-responders or unsuitable candidates for standard-of-care (pegylated interferon plus ribavirin) were randomized to receive mitoquinone (40 or 80 mg) or placebo once daily for 28 days, and serum aminotransferases and HCV RNA levels were measured. RESULTS: Both treatment groups showed significant decreases in absolute and percentage changes in serum alanine transaminase (ALT) from baseline to treatment day 28 (P<0.05). There was also a significant difference between incremental area under the curve for ALT between baseline and day 28 for the 40 mg treatment group against placebo (P<0.05). The differences in plasma ALT activity from baseline to day 28 in both mitoquinone groups compared with placebo did not reach significance (P>0.05). There was no change in HCV load on mitoquinone treatment. CONCLUSIONS: Administration of the mitochondria-targeted anti-oxidant mitoquinone significantly decreased plasma ALT and aspartate aminotransferase in patients with chronic HCV infection, and this suggests that mitoquinone may decrease necroinflammation in the liver in these patients. As mitochondrial oxidative damage contributes to many other chronic liver diseases, such as steatohepatitis, further studies using mitochondria-targeted anti-oxidants in HCV and other liver diseases are warranted.

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How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
Self-citation
Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C
McHutchison, J. G., Gordon, S. C., Schiff, E. R., Shiffman, M. L., Lee, W. M., Rustgi, V. K., Goodman, Z. D., Ling, M.-H., Cort, S., & Albrecht, J. K. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811193392101 · Cited by 3,457
The global burden of hepatitis C
Lavanchy, D. (2009) · Liver International · doi:10.1111/j.1478-3231.2008.01934.x · Cited by 1,353
Peginterferon Alfa-2a in Patients with Chronic Hepatitis C
Zeuzem, S., Feinman, S. V., Rasenack, J. W. F., Heathcote, E. J., Lai, M., Gane, E. J., O’Grady, J., Reichen, J., Moisés Diago, M., Lin, A., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012073432301 · Cited by 1,218
Self-citation
Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations
Murphy, M. P., & Smith, R. A. J. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105110 · Cited by 1,173
Self-citation
Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells
Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009093200 · Cited by 1,091
Self-citation
Global surveillance and control of hepatitis C
(1999) · Journal of Viral Hepatitis · doi:10.1046/j.1365-2893.1999.6120139.x · Cited by 903
Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C
Liang, T. J., Rehermann, B., Seeff, L. B., & Hoofnagle, J. H. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-4-200002150-00008 · Cited by 867
Non‐alcoholic fatty liver disease
Angulo, P., & Lindor, K. D. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.17.s1.10.x · Cited by 838
Delivery of bioactive molecules to mitochondria in vivo
Smith, R. A. J., Porteous, C. M., Gane, A. M., & Murphy, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931245100 · Cited by 725
Self-citation

Show all 33 references

Research works printed but not linked: 5

Reddy, 2009, Ribavirin, current role in the optimal clinical management of chronic hepatitis C, 50, 402
Chandran, 2009, Doxorubicin inactivates myocardial cytochrome c oxidase in rats, cardioprotection by Mito-Q, 96, 1388
Murphy, 2000, Drug delivery to mitochondria, the key to mitochondrial medicine, 41, 235
Snow, 2008, Phase II study of the mitochondrial antioxidant mitoquinone for Parkinson's disease, Neurology, 70, A483
Begriche, 2006, Mitochondrial dysfunction in NASH, causes, consequences and possible means to prevent it, 6, 1

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Amorim, R., Simões, I. C. M., Teixeira, J., Cagide, F., Potes, Y., Soares, P., Carvalho, A., Tavares, L. C., Benfeito, S., Pereira, S. P., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102400 · Cited by 48
Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria
Teixeira, J., Oliveira, C., Amorim, R., Cagide, F., Garrido, J. M. P. J., Ribeiro, J. A., Pereira, C. M. D. M., Silva, F., Andrade, P. B., Oliveira, P. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07272-y · Cited by 48
Mitochondrial bioenergetics and redox dysfunctions in hypercholesterolemia and atherosclerosis
Oliveira, H. C. F., & Vercesi, A. E. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.100840 · Cited by 49
Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
Jameson, V. J. A., Cochemé, H. M., Logan, A., Hanton, L. R., Smith, R. A. J., & Murphy, M. P. (2015) · Tetrahedron · doi:10.1016/j.tet.2015.09.014 · Cited by 47
Self-citation
New opportunities for targeting redox dysregulation in cardiovascular disease
Bubb, K. J., Drummond, G. R., & Figtree, G. A. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz183 · Cited by 50
Loss of Mitochondrial Control Impacts Renal Health
Srivastava, S. P., Kanasaki, K., & Goodwin, J. E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.543973 · Cited by 48
The swan-neck lesion: proximal tubular adaptation to oxidative stress in nephropathic cystinosis
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Self-citation
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Self-citation
Anthracycline chemotherapy‐mediated vascular dysfunction as a model of accelerated vascular aging
Clayton, Z. S., Hutton, D. A., Mahoney, S. A., & Seals, D. R. (2021) · Aging and Cancer · doi:10.1002/aac2.12033 · Cited by 44
Coenzyme Q10 Supplementation and Its Impact on Exercise and Sport Performance in Humans: A Recovery or a Performance-Enhancing Molecule?
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Mitochondrial Biogenesis: Regulation By Endogenous Gases During Inflammation and Organ Stress
Suliman, H. B., & Piantadosi, C. A. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140306095717 · Cited by 40
A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis
Chen, H., Gan, Q., Yang, C., Peng, X., Qin, J., Qiu, S., Jiang, Y., Tu, S., He, Y. Z., Li, S., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2027-8 · Cited by 40
Targeted Antioxidants in Exercise-Induced Mitochondrial Oxidative Stress: Emphasis on DNA Damage
Williamson, J., & Davison, G. W. (2020) · Antioxidants · doi:10.3390/antiox9111142 · Cited by 43
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Yoon, N. G., Lee, H., Kim, S.-Y., Hu, S., Kim, D., Yang, S., Hong, K. B., Lee, J. H., Kang, S., Kim, B., et al. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07099 · Cited by 38
Mitophagy in Alzheimer's disease and other metabolic disorders: A focus on mitochondrial-targeted therapeutics
Skawratananond, S., Xiong, D. X., Zhang, C., Tonk, S. S., Pinili, A., Delacruz, B., Pham, P., Smith, S. C., Navab, R., & Reddy, P. H. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102732 · Cited by 41
Systems biology of antioxidants
Andriantsitohaina, R., Duluc, L., Rodríguez, J., del Valle, L. G., Guevara-García, M., Simard, G., Soleti, R., Su, D., Velázquez‐Pérez, L., Wilson, J. X., et al. (2012) · Clinical Science · doi:10.1042/cs20110643 · Cited by 42
Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early‐onset gestational hypoxia
Spiroski, A., Niu, Y., Nicholas, L. M., Austin‐Williams, S., Camm, E. J., Sutherland, M. R., Ashmore, T. J., Skeffington, K. L., Logan, A., Ozanne, S. E., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002705r · Cited by 38
Self-citation
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Effect of Potassium Bromate on the Liver of Adult Male Albino Rat and A Possible Protective Role of Vitamin C: Histological, Immunohistochemical, and Biochemical Study
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[Mitochondrial reactive oxygen species].
Nishikawa, T., Kukidome, D., & Araki, E. (2016) · PubMed · Cited by 38
Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring
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Self-citation
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van Golen, R. F., Reiniers, M. J., Marsman, G., Alles, L. K., Rooyen, D. M. V., Petri, B., van der Mark, V. A., van Beek, A. A., Meijer, B., Maas, M. A. W., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.01.014 · Cited by 34
Self-citation
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Katta, S., Karnewar, S., Panuganti, D., Jerald, M. K., Sastry, B. K. S., & Kotamraju, S. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25865 · Cited by 33
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Capelôa, T., de Velde, J. A. V., d’Hose, D., Lipari, S., Derouane, F., Hamelin, L., Bedin, M., Vazeille, T., Duhoux, F. P., Murphy, M. P., et al. (2022) · Cancers · doi:10.3390/cancers14194918 · Cited by 33
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Authors: Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A. J., & Murphy, M. P.
Affiliations: Auckland City Hospital (NZ)
Waikato Hospital (NZ)
University of Otago (NZ)
MRC Mitochondrial Biology Unit (GB)
Corresponding author: Gane, Edward J.
ORCID: Gane, Edward J.
Weilert, Frank
Frampton, Christopher M.
Murphy, Michael P.
Venue: Liver International
Publisher: Wiley
Published: 2010-05-18
Volume: 30
Issue: 7
Pages: 1019-1026
ISSN: 0106-9543 (ISSN-L)
1478-3223
1478-3231
DOI: 10.1111/j.1478-3231.2010.02250.x
OpenAlex: W1623473717
Cited by: 379
References: 33
Citations by year: 2026: 18 · 2025: 29 · 2024: 15 · 2023: 26 · 2022: 29 · 2021: 27 · 2020: 33 · 2019: 24 · 2018: 28 · 2017: 21 · 2016: 24 · 2015: 21 · 2014: 23 · 2013: 18 · 2012: 23
FWCI: 12.81
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1932 d)
Locations: Liver International (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: mitoquinone, chronic hepatitis C, mitochondria-targeted antioxidants, oxidative stress, mitochondrial damage, liver injury, alanine aminotransferase, aspartate aminotransferase, HCV RNA viral load, necroinflammation
MeSH terms: Administration, Oral, Adult, Alanine Transaminase, Antioxidants, Antiviral Agents, Aspartate Aminotransferases, Double-Blind Method, Female, Genotype, Humans, Interferons, Liver, Male, Middle Aged, Mitochondria, Liver, Organophosphorus Compounds, Ribavirin, RNA, Viral, Time Factors, Ubiquinone, Biomarkers, Hepacivirus, Treatment Outcome, Viral Load, Hepatitis C, Chronic

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The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients: Mitoquinone and liver damage

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