Cited by 277Liver Disease and TransplantationLiver physiology and pathologyLiver Disease Diagnosis and Treatment

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Angiogenesis in chronic liver disease and its complications: Angiogenesis in CLD

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Coulon, Stephanie, Heindryckx, Femke, Geerts, Anja, Van Steenkiste, Christophe, Colle, Isabelle, Van Vlierberghe, Hans·2011·Liver International

DOI 10.1111/j.1478-3231.2010.02369.x

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Abstract

Nowadays, liver cancer, cirrhosis and other liver-related diseases are the fifth most common cause of mortality in the UK. Furthermore, chronic liver diseases (CLDs) are one of the major causes of death, which are still increasing year-on-year. Therefore, knowledge about the pathophysiology of CLDs and its complications is of uttermost importance. The goal of this review is to clarify the role of angiogenesis in the disease progression of various liver diseases. Looking closer at the pathophysiology of portal hypertension (PH), fibrosis, cirrhosis, non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), we find that angiogenesis is a recurring factor in the disease progression. In PH, several factors involved in its pathogenesis, such as hypoxia, oxidative stress, inflammation and shear stress are potential mediators for the angiogenic response. The progression from fibrosis to cirrhosis, the end-point of CLDs, is distinguished by a prolonged inflammatory and fibrogenic process that leads to an abnormal angioarchitecture distinctive for cirrhosis. In several stages of NASH, a link might be made between the disease progression and hepatic microvasculature changes. HCC is one of the most vascular solid tumours in which angiogenesis plays an important role in its development, progression and metastasis. The close relationship between the progression of CLDs and angiogenesis emphasises the need for anti-angiogenic therapy as a tool for blocking or slowing down the disease progression. The fact that angiogenesis plays a pivotal role in CLDs gives rise to new opportunities for treating CLDs and its complications.

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Authors: Coulon, S., Heindryckx, F., Geerts, A., Van Steenkiste, C., Colle, I., & Van Vlierberghe, H.
Affiliations: Ghent University (BE)
ORCID: Heindryckx, Femke
Geerts, Anja
Colle, Isabelle
Venue: Liver International
Publisher: Wiley
Published: 2010-11-15
Volume: 31
Issue: 2
Pages: 146-162
ISSN: 0106-9543 (ISSN-L)
1478-3223
DOI: 10.1111/j.1478-3231.2010.02369.x
OpenAlex: W1484083850
Cited by: 276
References: 194
Citations by year: 2026: 13 · 2025: 11 · 2024: 17 · 2023: 19 · 2022: 15 · 2021: 24 · 2020: 14 · 2019: 13 · 2018: 20 · 2017: 25 · 2016: 22 · 2015: 26 · 2014: 25 · 2013: 12 · 2012: 14
FWCI: 1.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1751 d)
Locations: Liver International (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: angiogenesis, chronic liver disease, portal hypertension, liver fibrosis, liver cirrhosis, nonalcoholic steatohepatitis, hepatocellular carcinoma, hypoxia, oxidative stress, inflammation, shear stress, hepatic microvasculature, anti-angiogenic therapy, disease progression
MeSH terms: Chronic Disease, Fatty Liver, Fibroblast Growth Factors, Carcinoma, Hepatocellular, Humans, Hypertension, Portal, Liver Cirrhosis, Liver Neoplasms, Models, Biological, Neovascularization, Pathologic, Platelet-Derived Growth Factor, Signal Transduction, Cadherins, Integrins, Disease Progression, Thrombospondins, Angiogenesis Inhibitors, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A, Angiopoietins, Angiostatins, Endostatins, Hypoxia-Inducible Factor 1, Microvessels, Non-alcoholic Fatty Liver Disease

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Angiogenesis in chronic liver disease and its complications: Angiogenesis in CLD

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