Cited by 277Liver Disease and TransplantationLiver physiology and pathologyLiver Disease Diagnosis and Treatment

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Angiogenesis in chronic liver disease and its complications: Angiogenesis in CLD

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Coulon, Stephanie, Heindryckx, Femke, Geerts, Anja, Van Steenkiste, Christophe, Colle, Isabelle, Van Vlierberghe, Hans·2011·Liver International

DOI 10.1111/j.1478-3231.2010.02369.x

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Abstract

Nowadays, liver cancer, cirrhosis and other liver-related diseases are the fifth most common cause of mortality in the UK. Furthermore, chronic liver diseases (CLDs) are one of the major causes of death, which are still increasing year-on-year. Therefore, knowledge about the pathophysiology of CLDs and its complications is of uttermost importance. The goal of this review is to clarify the role of angiogenesis in the disease progression of various liver diseases. Looking closer at the pathophysiology of portal hypertension (PH), fibrosis, cirrhosis, non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), we find that angiogenesis is a recurring factor in the disease progression. In PH, several factors involved in its pathogenesis, such as hypoxia, oxidative stress, inflammation and shear stress are potential mediators for the angiogenic response. The progression from fibrosis to cirrhosis, the end-point of CLDs, is distinguished by a prolonged inflammatory and fibrogenic process that leads to an abnormal angioarchitecture distinctive for cirrhosis. In several stages of NASH, a link might be made between the disease progression and hepatic microvasculature changes. HCC is one of the most vascular solid tumours in which angiogenesis plays an important role in its development, progression and metastasis. The close relationship between the progression of CLDs and angiogenesis emphasises the need for anti-angiogenic therapy as a tool for blocking or slowing down the disease progression. The fact that angiogenesis plays a pivotal role in CLDs gives rise to new opportunities for treating CLDs and its complications.

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Tumor angiogenesis: therapeutic implications
Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885
Angiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,379
Steatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288
Modes of resistance to anti-angiogenic therapy
Bergers, G., & Hanahan, D. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2442 · Cited by 2,953
Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor
Söker, S., Takashima, S., Miao, H. Q., Neufeld, G., & Klagsbrun, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81402-6 · Cited by 2,493
Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis
Pàez‐Ribes, M., Allen, E., Hudock, J., Takeda, T., Okuyama, H., Viñals, F., Inoue, M., Bergers, G., Hanahan, D., & Casanovas, O. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.027 · Cited by 2,373
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.
Mendel, D. B., Laird, A., Xin, X., Louie, S. G., Christensen, J. G., Li, G., Schreck, R., Abrams, T. J., Ngai, T. J., Lee, L. B., et al. (2003) · PubMed · Cited by 1,956
Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
Ebos, J. M. L., Lee, C. R., Cruz‐Muñoz, W., Bjarnason, G. A., Christensen, J. G., & Kerbel, R. S. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.021 · Cited by 1,739

Show all 194 references

Research works printed but not linked: 2

Ko, 2002, Nuclear factor kappaB dependency of platelet-activating factor-induced angiogenesis, Cancer Res, 62, 1809
Cayon, 2008, Gene expression in obese patients with non-alcoholic steatohepatitis, Rev Esp Enferm Dig, 100, 212

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Guérin, F., Wagner, M., Liné, A., Zappa, M., Fasseu, M., Paradis, V., Vilgrain, V., BEERS, B. E. V., Legagneux, J., Moreau, R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125493 · Cited by 11
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Sun, D., Shen, J., Tong, X., Ren, Y., Yuan, H., Li, Y., Wang, X., Chen, S., Zhu, P., Wang, X.-D., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101358 · Cited by 10
Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism
Yang, W., He, Y., Liu, S., Gan, L., Zhang, Z., Wang, J., Liang, J., Dong, Y., Wang, Q., Hou, Z., et al. (2016) · Gene · doi:10.1016/j.gene.2016.09.047 · Cited by 10
Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells
Wu, Y., Yin, A.-H., Sun, J., Xu, W.-H., & Zhang, C. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i33.4975 · Cited by 12
Serum levels of vascular endothelial growth factor in non-alcoholic fatty liver disease
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Asparaginyl endopeptidase may promote liver sinusoidal endothelial cell angiogenesis via PI3K/Akt pathway
Li, N., Liu, C., Ma, G., Tseng, Y., Pan, D., Chen, J., Li, F., Zeng, X., Luo, T., & Chen, S. (2018) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2018.5709/2018 · Cited by 10
Soluble fms‐like tyrosine kinase 1 (sFlt‐1): A novel biochemical marker for acute fatty liver of pregnancy
Trottmann, F., Raio, L., Amylidi-Mohr, S. K., Mosimann, B., Campos, A. J., Messerli, F. H., Risch, L., & Baumann, M. U. (2021) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.14218 · Cited by 10
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Zhang, J., Wu, F., Chang, W., & Kong, D. (2022) · Entropy · doi:10.3390/e24040465 · Cited by 10
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Zhang, Y., Wu, D., Tian, X., & Chen, B. (2023) · Scandinavian Journal of Immunology · doi:10.1111/sji.13349 · Cited by 10
SH-Alb inhibits phenotype remodeling of pro-fibrotic macrophage to attenuate liver fibrosis through SIRT3-SOD2 axis
Wu, N., Ma, S., Ding, H., Cao, H., Liu, T., Tian, M., Liu, Q., Bian, H., Yu, Z., Liu, C., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116919 · Cited by 9
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HBx promotes hepatocellular carcinoma progression by repressing the transcription level of miR-187-5p
Deng, Y., Wang, L., Zhang, Y., Sun, D., Min, H., Zhou, H., Xu, C., Xu, N., Qiu, F., Zhou, J., et al. (2023) · Aging · doi:10.18632/aging.204921 · Cited by 9
Expression of VEGFR-2 during Liver Regeneration after Partial Hepatectomy in a Bioluminescence Mouse Model
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Significance of circulating tumor cells in the portal vein regarding metastases and vascular invasion in hepatocellular carcinoma patients
Zhao, X., Zhao, J., Tao, L., Pan, Y., Yang, L., Zhang, X., Yuan, J., & Zhu, H. (2021) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-21-734 · Cited by 8
Moringa oleifera and Autophagy: Evidence from In Vitro Studies on Chaperone-Mediated Autophagy in HepG 2 Cancer Cells
Bopape, M., Tiloke, C., & Ntsapi, C. (2023) · Nutrition and Cancer · doi:10.1080/01635581.2023.2270215 · Cited by 11
Human recombinant endostatin Endostar attenuates hepatic sinusoidal endothelial cell capillarization in CCl4-induced fibrosis in mice
You, Q., Kong, L., Li, F., Wang, H., Liu, D.-G., PEI, F.-H., Song, J.-T., XU, J., & CHEN, J. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4103 · Cited by 8
A 3′ UTR SNP in COL18A1 Is Associated with Susceptibility to HBV Related Hepatocellular Carcinoma in Chinese: Three Independent Case-Control Studies
Wu, X., Wu, J., Xin, Z.-H., Wang, H., Zhu, X., Pan, L., Li, Z., Li, H. Y., & Liu, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033855 · Cited by 8
Splanchnic-aortic inflammatory axis in experimental portal hypertension
Aller, M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i44.7992 · Cited by 8
The Role of Non-alcoholic Fatty Liver Disease in Cardiovascular Disease
Francque, S. (2014) · European Cardiology Review · doi:10.15420/ecr.2014.9.1.10 · Cited by 8
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Li, G., Peng, Y., Tie-jian, Z., Lin, J., Duan, X.-L., Wei, Y., & Ma, J. (2017) · BioMed Research International · doi:10.1155/2017/5603216 · Cited by 8
Nanocarrier‐Mediated RNA Delivery Platform as a Frontier Strategy for Hepatic Disease Treatment: Challenges and Opportunities
Fan, J., Xiao, Z., Dong, Y., Ye, F., Yan, Q., Zhang, C., Yin, X., Li, Y., & Wang, T. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402933 · Cited by 7
Intrahepatic angiogenesis increases portal hypertension in hepatitis B patients with cirrhosis
Wang, L., Zhao, X., Feng, Y., Ma, X., Wu, H., & Zhu, Q. (2016) · Hepatology Research · doi:10.1111/hepr.12732 · Cited by 7
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Lv, L., Wang, D., Yin, J., Yang, T., Huang, B., Cao, Y., & Lu, J. (2022) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07660-z · Cited by 7
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Marcelo, K. L., Lin, F., Rajapakshe, K., Dean, A. M., Gonzales, N. M., Coarfa, C., Means, A. R., Goldie, L. C., & York, B. (2015) · Journal of Biological Methods · doi:10.14440/jbm.2015.77 · Cited by 7
Boosting pigment epithelial-derived factor: a promising approach for the treatment of early portal hypertension
Gentilucci, U. V., & Rombouts, K. (2014) · Gut · doi:10.1136/gutjnl-2014-307583 · Cited by 7
2'‐Hydroxyflavanone ameliorates mesenteric angiogenesis and portal‐systemic collaterals in rats with liver fibrosis
Hsin, I., Lee, J., Huo, T., Lee, F., Huang, H., Hsu, S., Wang, S.-S., Ho, H., Lin, H., & Lee, S. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13197 · Cited by 7
Angiogenesis and Hepatic Fibrosis: Western and Chinese Medicine Therapies on the Road
Wang, J., Zhang, Q., Cheng, J.-L., Chen, L.-Y., Nai-li, Y., Sun, G., & Chu, Y.-L. (2018) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-018-3007-1 · Cited by 7
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Shi, S., Zhang, M., Zhu, C., Zhu, S., Yu, J., Sui, Q., Xu, J., Ren, J., Zhang, J., Chen, P., et al. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111586 · Cited by 7
Single‐cell RNA sequencing of cystic fibrosis liver disease explants reveals endothelial complement activation
Declercq, M., Treps, L., Geldhof, V., Conchinha, N. V., de Rooij, L. P. M. H., Subramanian, A., Feyeux, M., Cotinat, M., Boeckx, B., Vinckier, S., et al. (2024) · Liver International · doi:10.1111/liv.15963 · Cited by 7
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Mishra, F., Yuan, Y., Yang, J. J., Li, B., Chan, P., & Liu, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137447 · Cited by 6
Effects of Nuclear Factor-E2-related factor 2/Heme Oxygenase 1 on splanchnic hemodynamics in experimental cirrhosis with portal hypertension
Qin, J., He, Y., Duan, M., & Luo, M. (2016) · Microvascular Research · doi:10.1016/j.mvr.2016.12.009 · Cited by 6
Pro‐angiogenic TIE‐2‐expressing monocytes/TEMs as a biomarker of the effect of sorafenib in patients with advanced hepatocellular carcinoma
Shoji, H., Yoshio, S., Mano, Y., Doi, H., Sugiyama, M., Osawa, Y., Kimura, K., Arai, T., Itokawa, N., Atsukawa, M., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.30804 · Cited by 6
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Chen, X., Guo, S., Meng, Q., Xie, J., Xiao, Y., Sun, Y., Yao, J., Jiang, X., Hong, A., & Chen, X. (2025) · IUBMB Life · doi:10.1002/iub.70014 · Cited by 5
Intratumoral bicarbonate functions as an adjuvant to potentiate PD-1 blockade in hepatocellular carcinoma
Wang, 迪. D. 王., Jin, K., Ying, C., Li, B., Zhang, G., Li, J., Chen, L., Chao, M., & Hu, X. (2026) · Oncogene · doi:10.1038/s41388-026-03836-3 · Cited by 5

Authors: Coulon, S., Heindryckx, F., Geerts, A., Van Steenkiste, C., Colle, I., & Van Vlierberghe, H.
Affiliations: Ghent University (BE)
ORCID: Heindryckx, Femke
Geerts, Anja
Colle, Isabelle
Venue: Liver International
Publisher: Wiley
Published: 2010-11-15
Volume: 31
Issue: 2
Pages: 146-162
ISSN: 0106-9543 (ISSN-L)
1478-3223
DOI: 10.1111/j.1478-3231.2010.02369.x
OpenAlex: W1484083850
Cited by: 276
References: 194
Citations by year: 2026: 13 · 2025: 11 · 2024: 17 · 2023: 19 · 2022: 15 · 2021: 24 · 2020: 14 · 2019: 13 · 2018: 20 · 2017: 25 · 2016: 22 · 2015: 26 · 2014: 25 · 2013: 12 · 2012: 14
FWCI: 1.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1751 d)
Locations: Liver International (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: angiogenesis, chronic liver disease, portal hypertension, liver fibrosis, liver cirrhosis, nonalcoholic steatohepatitis, hepatocellular carcinoma, hypoxia, oxidative stress, inflammation, shear stress, hepatic microvasculature, anti-angiogenic therapy, disease progression
MeSH terms: Chronic Disease, Fatty Liver, Fibroblast Growth Factors, Carcinoma, Hepatocellular, Humans, Hypertension, Portal, Liver Cirrhosis, Liver Neoplasms, Models, Biological, Neovascularization, Pathologic, Platelet-Derived Growth Factor, Signal Transduction, Cadherins, Integrins, Disease Progression, Thrombospondins, Angiogenesis Inhibitors, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A, Angiopoietins, Angiostatins, Endostatins, Hypoxia-Inducible Factor 1, Microvessels, Non-alcoholic Fatty Liver Disease

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Angiogenesis in chronic liver disease and its complications: Angiogenesis in CLD

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