Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence
Open accessAbstract
BACKGROUND: This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving. METHODS: Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive. RESULTS: Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2 (coding for GABA-A receptor alpha-2 subunit; rs11503014, nominal p= .001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominal p= .03). CONCLUSIONS: These pilot results suggest that cocaine craving shows variability among cocaine-dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue-reactivity, warranting studies in future research.
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Human genetics studies have noted associations between GABAAR genes and different aspects of alcoholism.
“Human genetics studies have noted associations between GABAAR genes and different aspects of alcoholism [93-98].”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [96]
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An emerging circuit pharmacology of GABAA receptors
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- Authors
- Smelson, D., Yu, L., Buyske, S., Gonzalez, G., Tischfield, J., Deutsch, C. K., & Ziedonis, D.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Rutgers, The State University of New Jersey (US)
- Venue
- The American Journal on Addictions
- Publisher
- Wiley
- Published
- 2012-08-10
- Volume
- 21
- Issue
- 5
- Pages
- 411-415
- ISSN
- 1055-0496 (ISSN-L)
- 1521-0391
- PMC
- PMC3425941
- OpenAlex
- W1872531735
- Cited by
- 15
- References
- 52
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal on Addictions (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institute on Drug Abuse (R03DA020434)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cocaine craving, cocaine dependence, GABRA2, OPRM1, mu-opioid receptor, single nucleotide polymorphisms, genetic association, African American men
- MeSH terms
- Adult, Black or African American, Cues, Feasibility Studies, Genotype, Humans, Male, Synaptic Transmission, Receptors, GABA-A, Logistic Models, Receptors, Opioid, mu, Cocaine-Related Disorders, Polymorphism, Single Nucleotide
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