Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor α2 subunit expression, and PKC ζ activity
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We have recently shown in rats that cocaine-induced behavioral sensitization can be reversed by a 5-day treatment with ondansetron given 3.5 h after daily pergolide injections. In this study we further investigated the molecular/neurochemical alterations underlying cocaine sensitization and pergolide/ondansetron-mediated reversal. Results revealed that glutamic acid decarboxylase (GAD(65)/GAD(67)) is higher abundant in the nucleus accumbens (NAc) than that in the caudate and medial prefrontal cortex (mPFC), while GABA(A) receptor alpha2 subunit level in the NAc shell is less abundant than that in the NAc core, mPFC and caudate. Cocaine sensitization led to (1) a decrease in GAD(67) expression, an increase in total protein kinase C (PKC) zeta subtype and phosphorylated PKC zeta/lambda levels in the NAc core; (2) a decrease in GAD(67) and GABA(A) receptor alpha2 subunit expression, and an increase in phosphorylated PKC zeta/lambda levels in the NAc shell; (3) an increase in GAD(67) expression in the caudate. Importantly, pergolide/ondansetron treatment reversed these alterations. These results suggest that reversal of cocaine-induced behavioral sensitization is associated with reversal of region-specific changes in GABA function and PKC activity in the striatum.
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A reduction in NAc α2GABAARs accompanies cocaine sensitization through long-term administration.
“A reduction in NAc α2GABAARs accompanies cocaine sensitization through long-term administration [120], while there is some evidence that these same receptors are required for the development of behavioral sensitization to cocaine in the first place [99,121], which may explain both initial sensitization and later acceleration of intake.”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [120]
Cites
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants
Wolf, M. E. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00090-7 · Cited by 934 · see citing works
Two isoforms of glutamate decarboxylase: why?
Soghomonian, J., & Martin, D. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01270-x · Cited by 643 · see citing works
Asada, H., Kawamura, Y., Maruyama, K., Kume, H., Ding, R.-G., Kanbara, N., Kuzume, H., Sanbo, M., Yagi, T., & Obata, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6496 · Cited by 556 · see citing works
The Sevenfold Way of PKC Regulation
Liu, W. S., & Heckman, C. A. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(98)00012-6 · Cited by 487 · see citing works
Nervous system distribution of the serotonin 5-HT3 receptor mRNA.
Tecott, L. H., Maricq, A. V., & Julius, D. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1430 · Cited by 368 · see citing works
Akbarian, S., & Huang, H. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.04.001 · Cited by 362 · see citing works
Asada, H., Kawamura, Y., Maruyama, K., Kume, H., Ding, R.-G., Ji, F. Y., Kanbara, N., Kuzume, H., Sanbo, M., Yagi, T., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1898 · Cited by 315 · see citing works
A New Anatomical Framework for Neuropsychiatric Disorders and Drug Abuse
Heimer, L. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.10.1726 · Cited by 308 · see citing works
Lüscher, B., & Keller, C. A. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.04.003 · Cited by 280 · see citing works
The Synaptic Framework for Chemical Signaling in Nucleus Accumbens
Meredith, G. E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09266.x · Cited by 215 · see citing works
Functional Specificity of Ventral Striatal Compartments in Appetitive Behaviors
KELLEY, A. E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09262.x · Cited by 198 · see citing works
Wolf, M. E. (2002) · Molecular Interventions · doi:10.1124/mi.2.3.146 · Cited by 185 · see citing works
The role of the synthetic enzyme GAD65 in the control of neuronal γ-aminobutyric acid release
Tian, N., Petersen, C., Kash, S., Baekkeskov, S., Copenhagen, D., & Nicoll, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12911 · Cited by 179 · see citing works
5-HT3 receptors control dopamine release in the nucleus accumbens of freely moving rats
Impérato, A., & Angelucci, L. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90533-8 · Cited by 154 · see citing works
Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices.
Kantor, L., & Gnegy, M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37287-8 · Cited by 153 · see citing works
Brandon, N. J., Jovanovic, J. N., & Moss, S. J. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00175-4 · Cited by 131 · see citing works
Lindefors, N. (1993) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(93)90018-n · Cited by 85 · see citing works
Zhang, X., Lee, T. H., Davidson, C., Lazarus, C., Wetsel, W. C., & Ellinwood, E. H. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301101 · Cited by 72 · see citing works
Self-citationBrowman, K. E., Kantor, L., Richardson, S., Badiani, A., Robinson, T., & Gnegy, M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)01040-3 · Cited by 55 · see citing works
Deurwaerdère, P. D., Moison, D., Navailles, S., Porras, G., & Spampinato, U. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03174.x · Cited by 52 · see citing works
Lee, C. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00336-6 · Cited by 52 · see citing works
A double-blind, placebo-controlled outpatient trial of pergolide for cocaine dependence
Malcolm, R. J., Kajdasz, D. K., Herron, J. E., Anton, R. F., & Brady, K. T. (2000) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(99)00151-9 · Cited by 47 · see citing works
Methamphetamine induces long-term changes in GABAA receptor α2 subunit and GAD67 expression
Zhang, X., Lee, T. H., Xiong, X., Chen, Q., Davidson, C., Wetsel, W. C., & Ellinwood, E. H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.046 · Cited by 43 · see citing works
Self-citationZhang, X., Mi, J., Wetsel, W. C., Davidson, C., Xiong, X., Chen, Q., Ellinwood, E. H., & Lee, T. H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.114 · Cited by 41 · see citing works
Self-citationGillies, D. M., Mylecharane, E. J., & Jackson, D. M. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00028-3 · Cited by 32 · see citing works
Enhanced reward-related responding following cholera toxin infusion into the nucleus accumbens
Kelley, A. E., & Holahan, M. R. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199705)26:1 · Cited by 31 · see citing works
Ondansetron, given during the acute cocaine withdrawal, attenuates oral cocaine self-administration
Davidson, C., Lazarus, C., Lee, T. H., & Ellinwood, E. H. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.09.041 · Cited by 21 · see citing works
Self-citationRicci, L. A., Stellar, J. R., & Todtenkopf, M. S. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.10.005 · Cited by 20 · see citing works
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cocaine‐induced neuroadaptations in glutamate transmission
Schmidt, H. D., & Pierce, R. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05144.x · Cited by 254 · see citing works
An emerging circuit pharmacology of GABAA receptors
Engin, E., Benham, R. S., & Rudolph, U. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.04.003 · Cited by 225 · see citing works
Ortinski, P. I., O’Donovan, B., Dong, X., & Kantor, B. (2017) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2017.04.002 · Cited by 146 · see citing works
Enoch, M.-A., Hodgkinson, C. A., Yuan, Q., Shen, P.-H., Goldman, D., & Roy, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.019 · Cited by 130 · see citing works
Famous, K. R., Kumaresan, V., Sadri‐Vakili, G., Schmidt, H. D., Mierke, D. F., Cha, J.-H. J., & Pierce, R. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1221-08.2008 · Cited by 119 · see citing works
Molecular Profiles of Drinking Alcohol to Intoxication in C57BL/6J Mice
Mulligan, M. K., Rhodes, J. S., Crabbe, J. C., Mayfield, R. D., Harris, R. A., & Ponomarev, I. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01384.x · Cited by 104 · see citing works
GABAA receptor subtype involvement in addictive behaviour
Stephens, D. N., King, S. L., Lambert, J. J., Belelli, D., & Duka, T. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12321 · Cited by 92 · see citing works
Psychostimulant-Induced Neuroadaptations in Nucleus Accumbens AMPA Receptor TransmissionPreprint
Pierce, R. C., & Wolf, M. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012021 · Cited by 87 · see citing works
Regulation of GABAA Receptor Subunit Expression in Substance Use Disorders
Barker, J., & Hines, R. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124445 · Cited by 52 · see citing works
Environmental enrichment during adolescence regulates gene expression in the striatum of mice
Thiriet, N., Amar, L., Toussay, X., Lardeux, V., Ladenheim, B., Becker, K. G., Cadet, J. L., Solinas, M., & Jaber, M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.030 · Cited by 51 · see citing works
Stimulation of mGluR5 in the Accumbens Shell Promotes Cocaine Seeking by Activating PKC Gamma
Schmidt, H. D., Schassburger, R. L., Guercio, L. A., & Pierce, R. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2284-13.2013 · Cited by 50 · see citing works
Ortinski, P. I., Briand, L. A., Pierce, R. C., & Schmidt, H. D. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.002 · Cited by 40 · see citing works
Schmidt, H. D., Kimmey, B. A., Arreola, A. C., & Pierce, R. C. (2015) · Addiction Biology · doi:10.1111/adb.12122 · Cited by 38 · see citing works
Alpha2-containing GABAA receptors are involved in mediating stimulant effects of cocaine
Morris, H. V., Dawson, G. R., Reynolds, D. S., Atack, J. R., Rosahl, T. W., & Stephens, D. N. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.02.010 · Cited by 29 · see citing works
Shi, P., Nie, J., Liu, H., Li, Y., Lu, X., Shen, X., Ge, F., Yuan, T., & Guan, X. (2019) · The FASEB Journal · doi:10.1096/fj.201802192rr · Cited by 28 · see citing works
Knockdown of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinson's disease
Horvath, L., van Marion, I., Taï, K., Nielsen, T. T., & Lundberg, C. (2011) · The Journal of Gene Medicine · doi:10.1002/jgm.1555 · Cited by 19 · see citing works
Treatment of the Psychostimulant-Sensitized Animal Model of Schizophrenia
Shuto, T., & Nishi, A. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00218.x · Cited by 16 · see citing works
Smelson, D., Yu, L., Buyske, S., Gonzalez, G., Tischfield, J., Deutsch, C. K., & Ziedonis, D. (2012) · The American Journal on Addictions · doi:10.1111/j.1521-0391.2012.00253.x · Cited by 15 · see citing works
Evaluation of anticonvulsant and nootropic effect of ondansetron in mice
Jain, S., Agarwal, N., Mediratta, P. K., & Sharma, K. (2012) · Human & Experimental Toxicology · doi:10.1177/0960327112436406 · Cited by 14 · see citing works
Purgianto, A., Loweth, J. A., Miao, J. J., Milovanovic, M., & Wolf, M. E. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.014 · Cited by 11 · see citing works
Yuan, L., Seo, J.-S., Kang, N. S., Keinan, S., Steele, S. E., Michelotti, G. A., Wetsel, W. C., Beratan, D. N., Gong, Y., Lee, T. H., et al. (2009) · Molecular BioSystems · doi:10.1039/b903036k · Cited by 11 · see citing works
Self-citationShen, S., Jiang, X.-S., Li, J., Straubinger, R. M., Suarez, M., Tu, C., Duan, X., Thompson, A. C., & Qu, J. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00137 · Cited by 10 · see citing works
de Souza, M. F., Toniazo, V. M., Frazzon, A. P. G., & Barros, H. M. T. (2009) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2009001100011 · Cited by 8 · see citing works
Lee, T. H., Szabo, S. T., Fowler, J. C., Mannelli, P., Mangum, O. B., Beyer, W. F., Patkar, A. A., & Wetsel, W. C. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.01.021 · Cited by 6 · see citing works
Self-citationde Azeredo, L. A., Marquardt, A. R., Frazzon, A. P. G., & Barros, H. M. T. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833b33af · Cited by 5 · see citing works
Clayman, C. L., Hwang, C., & CONNAUGHTON, V. P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286596 · Cited by 1 · see citing works
White, S. (2013) · ScholarlyCommons (University of Pennsylvania)
Treatment of Methamphetamine Dependence–Reply
Urschel, H. C. (2008) · Mayo Clinic Proceedings · doi:10.4065/83.3.370
Modulation of Dopamine Transporter Function by Tamoxifen
Mikelman, S. R. (2016) · Deep Blue (University of Michigan)
Oliver, & Robert, J. (2017) · UNM’s Digital Repository (University of New Mexico)
- Authors
- Chen, Q., Lee, T. H., Wetsel, W. C., Sun, Q.-A., Liu, Y., Davidson, C., Xiong, X., Ellinwood, E. H., & Zhang, X.
- Affiliations
- Duke University (US)
- Duke Medical Center (US)
- Corresponding author
- Zhang, Xiuwu
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 356
- Issue
- 3
- Pages
- 733-738
- ISSN
- 0006-291X (ISSN-L)
- PMC
- PMC1924471
- OpenAlex
- W2088117526
- Cited by
- 30
- References
- 31
- Citations by year
- 2023: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R21DA021185, R01DA012768, DA-10327, DA14323, R01DA010327, R01DA014323)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- cocaine sensitization, GAD67, glutamic acid decarboxylase, protein kinase C zeta, nucleus accumbens, caudate nucleus, medial prefrontal cortex, ondansetron, pergolide, GABAergic function, striatum
- MeSH terms
- Protein Kinase C zeta, Protein Kinase C-lambda, Animals, Behavior, Animal, Caudate Nucleus, Cocaine, Glutamate Decarboxylase, Isoenzymes, Male, Nucleus Accumbens, Pergolide, Protein Kinase C, Receptors, GABA-A, Stereotyped Behavior, Rats, Sprague-Dawley, Ondansetron, Prefrontal Cortex, Rats
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