Cited by 92Wound Healing and TreatmentsProtease and Inhibitor MechanismsMacrophage Migration Inhibitory Factor

Collagenase‐2 (MMP‐8) and matrilysin‐2 (MMP‐26) expression in human wounds of different etiologies

Pirilä, Emma, Korpi, Jarkko T, Korkiamäki, Timo, Jahkola, Tiina, Gutierrez‐Fernandez, Ana, Lopez‐Otin, Carlos, Saarialho‐Kere, Ulpu, Salo, Tuula +1 more·2007·Wound Repair and Regeneration

Abstract

Wound healing involves highly controlled events including reepithelialization, neoangiogenesis, and reformation of the stromal compartment. Matrix metalloproteinases (MMPs) are a family of neutral zinc‐dependent endopeptidases known to be essential for the wound‐healing process. MMP‐8 (collagenase‐2) is a neutrophil‐derived highly effective type I collagenase, recently indicated to be important for acute wound healing. MMP‐26 is a more recent and less well‐studied member of the MMP family. Our aim was to study the expression of MMP‐8 and MMP‐26 in human cutaneous wound repair and chronic wounds using histological methods and cell culture. MMP‐8 expression was associated with epithelial cells, neutrophils, and other inflammatory cells in chronic human wounds. MMP‐26 was prominently expressed in the extracellular compartment of most chronic wounds in close vicinity to the basement membrane area. MMP‐26 was also expressed in acute day 1 wounds with declining expression thereafter. In vitro wound experiments showed that both MMP‐8 and MMP‐26 were expressed by migrating human mucosal keratinocytes. Inhibiting MMP‐26 resulted in aberrant keratinocyte migration and proliferation. We conclude that MMP‐8 and MMP‐26 are differentially expressed in acute and chronic wounds.

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Crossref · 10.1111/j.1524-475x.2006.00184.x

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  • Neutrophil-derived proteases such as elastase and matrix metalloproteinases can degrade healthy extracellular matrix, and increased levels of these proteases have been repeatedly detected in chronic wounds.

    “neutrophil-derived proteases, such as elastase and matrix metalloproteinases (MMPs), can degrade healthy extracellular matrix (ECM), and increased levels of these proteases have been repeatedly detected in chronic wounds [52–56].”

    From Immunology of Wound Healing (2018) · cites this paper as [56]

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Authors
Pirilä, E., Korpi, J. T., Korkiamäki, T., Jahkola, T., Gutierrez‐Fernandez, A., Lopez‐Otin, C., Saarialho‐Kere, U., Salo, T., & Sorsa, T.
Affiliations
  • University of Oulu (FI)
  • Helsinki University Hospital (FI)
  • University of Helsinki (FI)
Venue
Wound Repair and Regeneration
Publisher
Wiley
Published
2007-01
Volume
15
Issue
1
Pages
47-57
ISSN
  • 1067-1927 (ISSN-L)
  • 1524-475X
OpenAlex
W2142036444
Cited by
92
References
43
Citations by year
2025: 1 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 6
FWCI
7.26
Type
journal article
Language
en
Open access
closed
Locations
  • Wound Repair and Regeneration (publishedVersion)
  • PubMed (publishedVersion)
Funders
Helsingin ja Uudenmaan Sairaanhoitopiiri
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords
MMP-8, MMP-26, matrix metalloproteinases, wound healing, chronic wounds, acute wounds, keratinocyte migration, keratinocyte proliferation, basement membrane, neutrophils, epithelial cells, extracellular matrix
MeSH terms
Acute Disease, Aged, Aged, 80 and over, Chronic Disease, Female, Humans, Male, Middle Aged, Skin Ulcer, Varicose Ulcer, Vasculitis, Wound Healing, Matrix Metalloproteinase 8, Diabetes Complications, Matrix Metalloproteinases, Secreted

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