Neutrophils and Wound Repair: Positive Actions and Negative Reactions
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SIGNIFICANCE: Neutrophils are one of the most abundant cells of the immune system and they are extremely active during the repair of cutaneous wounds. In general, the antimicrobial activity of neutrophils is effective and allows these cells to carry out their primary function of preventing wounds from becoming infected. RECENT ADVANCES: It is now known that in addition to sterilizing the wound, the weapons used by neutrophils to kill potential pathogens can also cause significant tissue damage to the host. This additional damage can lead to delayed healing and excessive scar formation. CRITICAL ISSUES: Much of the host damage caused by neutrophils results from the activity of proteases secreted by these cells. The clinical significance of this problem is highlighted by numerous studies showing that high levels of neutrophil-derived proteases are associated with chronic, non-healing wounds. FUTURE DIRECTIONS: Studies are currently being performed to evaluate new ways of counteracting protease activity in chronic wounds. Additional studies will have to be carried out to determine whether neutralizing neutrophil proteases can improve the healing of chronic wounds without sacrificing the ability of neutrophils to eliminate pathogens and risking infection.
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Neutrophils defend against wound infection by phagocytosing pathogens and killing them through release of reactive oxygen species, proteases, or antimicrobial proteins.
“neutrophils defend against wound infection by phagocytosing pathogens then killing them through release of reactive oxygen species, proteases, or antimicrobial proteins [28].”
From Immunology of Wound Healing (2018) · cites this paper as [28]
In impaired models of wound healing such as diabetes, where infection risk is higher, neutrophils are clearly required.
“In impaired models of wound healing, such as diabetes, where infection risk is higher, neutrophils are clearly required [28].”
From Immunology of Wound Healing (2018) · cites this paper as [28]
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- Authors
- Wilgus, T. A., Roy, S., & McDaniel, J. C.
- Affiliations
- The Ohio State University (US)
- Venue
- Advances in Wound Care
- Publisher
- SAGE Publications
- Published
- 2013-09
- Volume
- 2
- Issue
- 7
- Pages
- 379-388
- ISSN
- 2162-1918 (ISSN-L)
- 2162-1934
- PMC
- PMC3763227
- OpenAlex
- W2045982747
- Cited by
- 616
- References
- 47
- Citations by year
- 2026: 58 · 2025: 66 · 2024: 84 · 2023: 64 · 2022: 63 · 2021: 66 · 2020: 66 · 2019: 38 · 2018: 34 · 2017: 35 · 2016: 23 · 2015: 13 · 2014: 4
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in Wound Care (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ohio State University (UL1RR025755)
- National Institutes of Health (DK076566)
- National Cancer Institute (R01CA127109)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076566)
- National Center for Research Resources (UL1RR025755)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- neutrophils, wound healing, skin wounds, chronic wounds, neutrophil proteases, tissue damage, delayed healing, scar formation, antimicrobial activity, wound infection
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