Cited by 616Wound Healing and TreatmentsNeutrophil, Myeloperoxidase and Oxidative MechanismsProtease and Inhibitor Mechanisms

Neutrophils and Wound Repair: Positive Actions and Negative Reactions

Open access
Wilgus, Traci A., Roy, Sashwati, McDaniel, Jodi C.·2013·Advances in Wound Care

Abstract

SIGNIFICANCE: Neutrophils are one of the most abundant cells of the immune system and they are extremely active during the repair of cutaneous wounds. In general, the antimicrobial activity of neutrophils is effective and allows these cells to carry out their primary function of preventing wounds from becoming infected. RECENT ADVANCES: It is now known that in addition to sterilizing the wound, the weapons used by neutrophils to kill potential pathogens can also cause significant tissue damage to the host. This additional damage can lead to delayed healing and excessive scar formation. CRITICAL ISSUES: Much of the host damage caused by neutrophils results from the activity of proteases secreted by these cells. The clinical significance of this problem is highlighted by numerous studies showing that high levels of neutrophil-derived proteases are associated with chronic, non-healing wounds. FUTURE DIRECTIONS: Studies are currently being performed to evaluate new ways of counteracting protease activity in chronic wounds. Additional studies will have to be carried out to determine whether neutralizing neutrophil proteases can improve the healing of chronic wounds without sacrificing the ability of neutrophils to eliminate pathogens and risking infection.

Integrity signals

Registry

Crossref · 10.1089/wound.2012.0383

Cites

47 of 47 references verified0 citation errors · 0 not checkable

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  • Neutrophils defend against wound infection by phagocytosing pathogens and killing them through release of reactive oxygen species, proteases, or antimicrobial proteins.

    “neutrophils defend against wound infection by phagocytosing pathogens then killing them through release of reactive oxygen species, proteases, or antimicrobial proteins [28].”

    From Immunology of Wound Healing (2018) · cites this paper as [28]

  • In impaired models of wound healing such as diabetes, where infection risk is higher, neutrophils are clearly required.

    “In impaired models of wound healing, such as diabetes, where infection risk is higher, neutrophils are clearly required [28].”

    From Immunology of Wound Healing (2018) · cites this paper as [28]

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Authors
Wilgus, T. A., Roy, S., & McDaniel, J. C.
Affiliations
The Ohio State University (US)
Venue
Advances in Wound Care
Published
2013-09
Volume
2
Issue
7
Pages
379-388
ISSN
  • 2162-1918 (ISSN-L)
  • 2162-1934
OpenAlex
W2045982747
Cited by
616
References
47
Citations by year
2026: 58 · 2025: 66 · 2024: 84 · 2023: 64 · 2022: 63 · 2021: 66 · 2020: 66 · 2019: 38 · 2018: 34 · 2017: 35 · 2016: 23 · 2015: 13 · 2014: 4
FWCI
2.23
Type
journal article
Language
en
Open access
Locations
  • Advances in Wound Care (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ohio State University (UL1RR025755)
  • National Institutes of Health (DK076566)
  • National Cancer Institute (R01CA127109)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076566)
  • National Center for Research Resources (UL1RR025755)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords
neutrophils, wound healing, skin wounds, chronic wounds, neutrophil proteases, tissue damage, delayed healing, scar formation, antimicrobial activity, wound infection

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