The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model
Abstract
Bacterial biofilms have gained increasing visibility in recent years as a ubiquitous form of survival for microorganisms in myriad environments. A number of in vivo models exist for the study of biofilms in the setting of medically relevant implanted foreign bodies. Growing evidence has demonstrated the presence of bacterial biofilms in the setting of a number of chronic wound states including pressure sores, diabetic foot ulcers, and venous stasis ulcers. Here we present a novel murine cutaneous wound system that directly demonstrates delayed reepithelialization caused by the presence of a bacterial biofilm. We established biofilms using either Staphylococcus aureus or Staphylococcus epidermidis in splinted cutaneous punch wounds created on the backs of normal C57Bl6/J mice. Wound reepithelialization was significantly delayed by bacterial biofilms. This effect was specifically dependent on the ability of the bacteria to form biofilms as demonstrated by exogenous administration of biofilm inhibiting peptides and the use of mutant Staphylococcus spp. deficient in biofilm formation. This represents the first direct evidence for the effect of bacterial biofilms on cutaneous wound healing.
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“However many bacteria, including both commensal bacteria, such as S. epidermidis, and opportunistic microbes are capable of forming biofilms.10”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [10]
Citations
Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
Donlan, R. M., & Costerton, J. W. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.167-193.2002 · Cited by 6,644
Biofilms: Microbial Life on Surfaces
Donlan, R. M. (2002) · Emerging infectious diseases · doi:10.3201/eid0809.020063 · Cited by 4,894
Mechanisms of biofilm resistance to antimicrobial agents
Mah, T.-F. C., & O'Toole, G. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01913-2 · Cited by 3,921
Biofilms as Complex Differentiated Communities
Stoodley, P., Sauer, K., Davies, D. G., & Costerton, J. W. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.160705 · Cited by 3,151
James, G. A., Swogger, E., Wolcott, R., Pulcini, E. D., Secor, P., Sestrich, J., Costerton, J. W., & Stewart, P. S. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00321.x · Cited by 1,543
Reducing implant-related infections: active release strategies
Hetrick, E. M., & Schoenfisch, M. H. (2006) · Chemical Society Reviews · doi:10.1039/b515219b · Cited by 1,201
Otto, M. J. (2008) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-75418-3_10 · Cited by 903
Biofilm in Implant Infections: Its Production and Regulation
Costerton, J. W., Montanaro, L., & Arciola, C. R. (2005) · The International Journal of Artificial Organs · doi:10.1177/039139880502801103 · Cited by 804
Quantitative and reproducible murine model of excisional wound healing
Galiano, R. D., Michaels, V. J., Dobryansky, M., Levine, J. P., & Gurtner, G. C. (2004) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2004.12404.x · Cited by 761
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Lebeaux, D., Ghigo, J., & Beloin, C. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00013-14 · Cited by 1,378
Staphylococcus aureus biofilms
Archer, N. K., Mazaitis, M. J., Costerton, J. W., Leid, J. G., Powers, M. E., & Shirtliff, M. E. (2011) · Virulence · doi:10.4161/viru.2.5.17724 · Cited by 1,072
The wound microbiota: microbial mechanisms of impaired wound healing and infection
Uberoi, A., McCready-Vangi, A. R., & Grice, E. A. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01035-z · Cited by 963
Acute and Impaired Wound Healing
Demidova‐Rice, T. N., Hamblin, M. R., & Herman, I. M. (2012) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000416006.55218.d0 · Cited by 741
Polymicrobial Interactions: Impact on Pathogenesis and Human Disease
Peters, B. M., Jabra‐Rizk, M. A., O’May, G. A., Costerton, J. W., & Shirtliff, M. E. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00013-11 · Cited by 733
Metadata
- Authors
- Schierle, C. F., De la Garza, M., Mustoe, T. A., & Galiano, R. D.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Galiano, Robert D.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2009-05
- Volume
- 17
- Issue
- 3
- Pages
- 354-359
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W1986560085
- Cited by
- 311
- References
- 43
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 20 · 2021: 25 · 2020: 19 · 2019: 22 · 2018: 28 · 2017: 21 · 2016: 26 · 2015: 12 · 2014: 18 · 2013: 21 · 2012: 23
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Wound Repair and Regeneration (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- bacterial biofilms, Staphylococcus aureus, Staphylococcus epidermidis, skin wound healing, re-epithelialization, chronic wounds, pressure ulcers, diabetic foot ulcer, venous leg ulcers
- MeSH terms
- Animals, Disease Models, Animal, Male, Mice, Inbred C57BL, Skin, Staphylococcal Infections, Staphylococcus aureus, Staphylococcus epidermidis, Wound Healing, Wound Infection, Wounds and Injuries, Biofilms, Mice
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