CEACAM1 deficiency delays important wound healing processes
Open accessAbstract
Cutaneous wound healing is a complex process that requires the coordination of many cell types to achieve proper tissue repair. Four major overlapping processes have been identified in wound healing: hemostasis, inflammation, reepithelialization and granulation tissue formation, and tissue remodeling. Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) is a glycoprotein expressed in epithelial, endothelial, lymphoid, and myeloid cells. Given its known roles in angiogenesis, cell migration, and immune functions, we hypothesized that CEACAM1 might also be involved in cutaneous wound healing and that a number of relevant CEACAM1‐positive cell types might contribute to wound healing. To evaluate the role of CEACAM1 in these processes, 6‐mm‐diameter skin wounds were inflicted on Ceacam1–/– and wild‐type mice. Herein, we demonstrate that CEACAM1 deletion indeed affects wound healing in three key ways. Infiltration of F4/80+ macrophages was decreased in Ceacam1–/– wounds, altering inflammatory processes. Reepithelialization in Ceacam1–/– wounds was delayed. Furthermore, the vascular density of the granulation tissue in Ceacam1–/– wounds was significantly diminished. These results confirm CEACAM1's role as an important regulator of key processes in cutaneous wound healing, although whether this works via a specific cell type or alterations in the functioning of multiple processes remains to be determined.
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S. epidermidis association promotes expression of angiogenesis genes Ang and Hgf and tissue repair genes Ceacam1, Grn, Hmox1, Igf1, and Pdgfa.
“S. epidermidis association promoted the expression of genes associated specifically with angiogenesis, including angiogenin (Ang) and Hgf (47, 48), as well as genes that more broadly promote tissue repair, like Ceacam1, Grn, Hmox1, Igf1, and Pdgfa (49–53) (Fig. 3R).”
From MAIT cells are imprinted by the microbiota in early life and promote tissue repair (2019) · cites this paper as [51]
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MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Constantinides, M. G., Link, V. M., Tamoutounour, S., Wong, A. C., Perez-Chaparro, P. J., Han, S.-J., Chen, Y. E., Li, K., Farhat, S., Weckel, A., et al. (2019) · Science · doi:10.1126/science.aax6624 · Cited by 567 · see citing works
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- Authors
- LeBlanc, S., Arabzadeh, A., Benlolo, S., Breton, V., Turbide, C., Beauchemin, N., & Nouvion, A.
- Affiliations
- Institut du cancer Rosalind & Morris Goodman (CA)
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2011-11
- Volume
- 19
- Issue
- 6
- Pages
- 745-752
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W2096883846
- Cited by
- 12
- References
- 31
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2019: 1 · 2018: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Wound Repair and Regeneration (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- CEACAM1, skin wound healing, macrophage infiltration, inflammation, re-epithelialization, granulation tissue, vessel density, tissue remodeling, angiogenesis
- MeSH terms
- Animals, Epithelium, Female, Granulation Tissue, Immunohistochemistry, Inflammation, Male, Mice, Inbred C57BL, Skin, Wound Healing, Antigens, CD, Cell Adhesion Molecules, Mice, Knockout, Neovascularization, Physiologic, Mice
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