First clinical experience with BION implants for therapeutic electrical stimulation
Abstract
The objective of this study was to assess the usability and safety of BION injectable neuromuscular microstimulators for therapeutic electrical stimulation (TES) to treat two conditions involving disuse atrophy: poststroke shoulder subluxation in hemiplegic subjects and knee osteoarthritis. Clinicians were provided with PC-based software to track implants and to design the exercise programs. Subjects self-administered TES (3 sessions/day, 10-30 min/session) for 6 or 12 weeks. Outcome measures included subluxation for the shoulder study and knee function and pain for the osteoarthritis study. All subjects were comfortable with the BION equipment and therapy; eight of 10 experimental subjects elected to continue treatment after the study period. Shoulder subluxation was reduced by 55% ± 54%; knee function was enhanced by 65% ± 24%; and knee pain decreased by 78% ± 18%. The devices did not migrate and did not cause inflammation or pain. Thresholds were stable over time. We conclude that the use of BION implants to exercise atrophic muscles was well-accepted and provided effective rehabilitation in these two clinical conditions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BION microstimulators have been used in human patients for electrical muscle stimulation to prevent disuse atrophy and secondary complications.
“These microstimulators have been used in human patients for muscle electrical stimulation to prevent disuse atrophy and secondary complications (Dupont-Salter et al., 2004) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Dupont-Salter et al., 2004
Cited by
Sorted by citations
Neural Stimulation and Recording Electrodes
Cogan, S. F. (2008) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.10.061807.160518 · Cited by 2,243 · see citing works
Navarro, X., Krueger, T. B., Lago, N., Micera, S., Stieglitz, T., & Dario, P. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.10303.x · Cited by 845 · see citing works
The potential of virtual reality and gaming to assist successful aging with disability
Lange, B. S., Requejo, P., Flynn, S. M., Rizzo, A. A., Valero-Cuevas, F. J., Baker, L., & Winstein, C. (2010) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2009.12.007 · Cited by 208 · see citing works
Ortiz-Catalan, M., Brånemark, R., Håkansson, B., & Delbeke, J. (2012) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-11-33 · Cited by 144 · see citing works
Salminger, S., Sturma, A., Hofer, C., Evangelista, M., Perrin, M., Bergmeister, K. D., Roche, A. D., Hasenoehrl, T., Dietl, H., Farina, D., et al. (2019) · Science Robotics · doi:10.1126/scirobotics.aaw6306 · Cited by 139 · see citing works
“The housing of the IMES sensor was previously used in an implantable microstimulation device (the BION) for poststroke hemiplegic patients with shoulder subluxation (20).”
Method
- Authors
- Salter, A.-C. D., Bagg, S. D., Creasy, J. L., Romano, C., Romano, D., Richmond, F. J. R., & Loeb, G. E.
- Affiliations
- University of Southern California (US)
- Queen's University (CA)
- Corresponding author
- Richmond, Frances J.R.
- Venue
- Neuromodulation: Technology at the Neural Interface
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 7
- Issue
- 1
- Pages
- 38-47
- ISSN
- 1094-7159 (ISSN-L)
- OpenAlex
- W2150078773
- Cited by
- 66
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuromodulation Technology at the Neural Interface (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- electrotherapy, disuse atrophy, hemiplegia, knee osteoarthritis, self-administered exercise, implant safety, implant migration, knee function, knee pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
