The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhibition of Experimental Seizures in Canines by Repetitive Vagal Stimulation
Abstract
Summary: Repetitive electrical stimulation of the canine cervical vagus nerve interrupts or abolishes motor seizures induced by strychnine and tremors induced by pentylenetetrazol (PTZ). Tremors were defined as rhythmic alternating contractions of opposing muscle groups, exerting much less force than seizure contractions. Seizures were induced by injection boluses of strychnine or PTZ at 1‐ to 4‐min intervals until sustained muscle activity was observed electromyographically (EMG). Vagal stimulation terminated seizures in 0.5‐5 s. There were prolonged periods with no spontaneous EMG activity after stimulation. The period of protection was approximately four times the stimulation period. The antiseizure actions of vagal stimulation were not altered by transection of the vagus distal to the stimulating electrode. Optimal stimulus parameters were estimated: strength, ‐20 V (electrode resistance 1‐5 ω); frequency 20–30 Hz; duration, ‐0.2 ms. These data suggest that the antiseizure effects derive from stimulation of small‐diameter afferent unmyelinated fibers in the vagus nerve. These results may form the basis of a new therapeutic approach to epilepsy.
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Citations
Cites
Effects of Vagal Stimulation on Experimentally Induced Seizures in Rats
Woodbury, D. M., & Woodbury, J. W. (1990) · Epilepsia · doi:10.1111/j.1528-1157.1990.tb05852.x · Cited by 369
Cited by
Ben‐Menachem, E., Mañon‐Espaillat, R., Ristanovic, R., Wilder, B. J., Stefan, H., Mirza, W., Tarver, W. B., Wernicke, J. F., & First International Vagus Nerve Stimulation Study Group (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb02482.x · Cited by 683
Vagus-nerve stimulation for the treatment of epilepsy
Ben-Menachem, E. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00220-x · Cited by 560
Locus Coeruleus Lesions Suppress the Seizure‐Attenuating Effects of Vagus Nerve Stimulation
Krahl, S. E., Clark, K. B., Smith, D. C., & Browning, R. A. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01155.x · Cited by 555
Prospective Long‐Term Study of Vagus Nerve Stimulation for the Treatment of Refractory Seizures
DeGiorgio, C. M., Schachter, S. C., Handforth, A., Salinsky, M., Thompson, J., Uthman, B., Reed, R., Collin, S., Tecoma, E., Morris, G. L., et al. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb00325.x · Cited by 479
Vagus nerve stimulation: a new tool for brain research and therapy
George, M. S., Sackeim, H. A., Rush, A. J., Marangell, L. B., Nahas, Z., Husain, M. M., Lisanby, S., Burt, T., Goldman, J., & Ballenger, J. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00308-x · Cited by 461
Metadata
- Authors
- Zabara, J.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 1992-11
- Volume
- 33
- Issue
- 6
- Pages
- 1005-1012
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W2104654650
- Cited by
- 395
- References
- 1
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zabara, J. (1992). Inhibition of Experimental Seizures in Canines by Repetitive Vagal Stimulation. Epilepsia. https://doi.org/10.1111/j.1528-1157.1992.tb01751.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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