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Cited by 274

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Efficacy of the Ketogenic Diet for Intractable Seizure Disorders: Review of 58 Cases

Kinsman, Stephen L., Vining, Eileen P. G., Quaskey, Shirley A., Mellits, David, Freeman, John M.·1992·Epilepsia
DOI 10.1111/j.1528-1157.1992.tb01770.x
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Abstract

Summary: The ketogenic diet was developed in the 1920s as a treatment for intractable childhood seizures when few antiepileptic drugs (AEDs) were available. There are still children whose seizures are refractory even to modern therapy, but use of the ketogenic diet appears to be waning. At Johns Hopkins, we continue to believe that the diet is very effective and well accepted by patients and families. To reevaluate our opinion of the efficacy and acceptability of this form of therapy in patients cared for in the 1980s with the newer AEDs, we analyzed the records of 58 consecutive patients who had been started on the diet. Before using the diet, 80% of the patients had multiple seizure types and 88% were treated with multiple AEDs; these children were among our most intractable patients. Despite this, seizure control improved in 67% of patients with the ketogenic diet, and actuarial analysis indicated that 75% of these improved patients continued the diet for at least 18 months. Sixty‐four percent had AEDs reduced, 36% became more alert, and 23% had improved behavior. The improvement in these patients with intractable seizures and the length of time that families maintained the regimen indicate that the ketogenic diet continues to have a very useful therapeutic role in selected patients and their families.

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Metadata

Authors
Kinsman, S. L., Vining, E. P. G., Quaskey, S. A., Mellits, D., & Freeman, J. M.
Venue
Epilepsia
Publisher
Wiley
Published
1992-11
Volume
33
Issue
6
Pages
1132-1136
ISSN
  • 0013-9580 (ISSN-L)
  • 1528-1167
DOI
10.1111/j.1528-1157.1992.tb01770.x
OpenAlex
W2077741298
Cited by
274
References
16
FWCI
1.62
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Efficacy of the Ketogenic Diet for Intractable Seizure Disorders: Review of 58 Cases. https://app.cochat.ai/papers/10.1111/j.1528-1157.1992.tb01770.x
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Kinsman, S. L., Vining, E. P. G., Quaskey, S. A., Mellits, D., & Freeman, J. M. (1992). Efficacy of the Ketogenic Diet for Intractable Seizure Disorders: Review of 58 Cases. Epilepsia. https://doi.org/10.1111/j.1528-1157.1992.tb01770.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.