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Cited by 634Epilepsy research and treatmentHealth Systems, Economic Evaluations, Quality of LifeHealth Education and Validation

The DOI matches its Crossref record; 72 of the 73 references it cites were found in a registry or an index.

Development of the Quality of Life in Epilepsy Inventory

Devinsky, Orrin, Vickrey, Barbara G., Cramer, Joyce, Perrine, Kenneth, Hermann, Bruce, Meador, Kimford, Hays, Ron D.·1995·Epilepsia
DOI 10.1111/j.1528-1157.1995.tb00467.x
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Abstract

Summary: We developed an instrument to measure health‐related quality of life (HRQOL) in epilepsy. A 99‐item inventory was constructed from the RAND 36‐Item Health Survey (generic core), with 9 additional generic items, 48 epilepsy‐targeted items, and 6 other items concerning attitudes toward epilepsy and self‐esteem. We administered the 99‐item inventory to 304 adults with epilepsy at 25 epilepsy centers. Patients and patient‐designated proxies completed the inventory and were retested 1–91 days later. A multitrait scaling analysis of these data led to retention of 86 items distributed in 17 multiitem scales (Cronbach's alpha ranged from 0.78 to 0.92). Factor analysis of the 17 multiitem scales yielded four underlying dimensions of health: an epilepsy‐targeted dimension, a cognitive factor, mental health, and physical health. Construct validity was supported by significant patient‐proxy correlations for all scales and correlations between neuropsychologic tests and self‐reported emotional and cognitive function (all p values < 0.05). There were significant negative correlations between the four factor scores derived from the HRQOL scales and neurotoxicity, systemic toxicity, and health care utilization (except for the correlation between mental health factor and health care utilization; all p values < 0.05). Patients who were seizure‐free in the preceding year reported better HRQOL for the overall score, three of the four factor scores, and 8 of the 17 scale scores than did patients with a high frequency of seizures. Relative validity analysis showed that the epilepsy‐targeted factor and three of its four component scales were more sensitive to categorization of patients by severity of seizure frequency and type than scales tapping physical health, mental health, or cognitive function. These cross‐sectional data support the reliability and validity of this measure of HRQOL in epilepsy. The addition of an epilepsy‐targeted supplement to the generic core improved the sensitivity to severity of epilepsy. The 86 items included in the field testing were supplemented by three additional items to form the Quality of Life in Epilepsy (QOLIE‐89) inventory.

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Crossref · 10.1111/j.1528-1157.1995.tb00467.x

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Citations

Cites

Show all 73 references

Research works printed but not linked: 11

  1. Chadwick D, 1991, Randomized study of antiepileptic drug withdrawal in patients in remission, Lancer, 337, 1175
  2. Hermann BP, 1991, Epilepsy and behavior, 23
  3. Devinsky O, Epilepsy: a comprehensive textbook
  4. Thompson P, 1991, Living with intractable epilepsy: impact on family members, Epilepsia, 32, 42
  5. 10.1016/0277-9536(94)90396-4 · DOI
  6. 10.1016/0920-1211(91)90071-M · DOI
  7. Vickrey BG, 1993, QOLIE‐89 (version 1.0) scoring manual
  8. Vickrey BG, 1993, Quality of life and quality of care in epilepsy: update 1993, 27
  9. Nunnally J, 1978, Psychometric theory
  10. Shumaker SA, 1990, Quality of life assessments in clinical trials, 95
  11. 10.1016/0920-1211(93)90041-5 · DOI

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Metadata

Authors
Devinsky, O., Vickrey, B. G., Cramer, J., Perrine, K., Hermann, B., Meador, K., & Hays, R. D.
Affiliations
  • New York University Langone Orthopedic Hospital (US)
  • RAND Corporation (US)
  • Yale University (US)
  • University of Tennessee Health Science Center (US)
  • Augusta University (US)
  • University of California, Los Angeles (US)
ORCID
Venue
Epilepsia
Publisher
Wiley
Published
1995-11
Volume
36
Issue
11
Pages
1089-1104
ISSN
  • 0013-9580 (ISSN-L)
  • 1528-1167
DOI
10.1111/j.1528-1157.1995.tb00467.x
OpenAlex
W2124800861
Cited by
634
References
73
Citations by year
2026: 16 · 2025: 16 · 2024: 14 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 17 · 2019: 20 · 2018: 14 · 2017: 21 · 2016: 14 · 2015: 23 · 2014: 32 · 2013: 21 · 2012: 15
FWCI
11.64
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3563 d)
Locations
  • Epilepsia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
  • Health Sciences › Nursing › Research and Theory › Health Education and Validation
Keywords
epilepsy, health-related quality of life, QOLIE-89, instrument development, RAND-36, patient-proxy agreement, construct validity, factor analysis, seizure frequency, epilepsy severity, mental health, cognitive function, physical health, health care utilization, neurotoxicity, self-esteem, attitudes toward epilepsy
MeSH terms
Adolescent, Adult, Aged, Attitude to Health, Epilepsy, Factor Analysis, Statistical, Female, Health Status, Humans, Male, Middle Aged, Personality Inventory, Psychometrics, Quality of Life, Self Concept, Severity of Illness Index, Reproducibility of Results, Prevalence

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