The autism‐epilepsy connection
Open accessAbstract
Summary The high prevalence of epilepsy in children with autism supports a neurobiologic etiology for autism. It remains unclear whether seizures and epileptiform activity on the EEG are causative or comorbid. It is also uncertain if focal epileptiform EEG abnormalities may be associated with stable cognitive impairment. Even less clear is whether these EEG abnormalities can result in the combination of language and social dysfunction seen in autistic spectrum disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The 'broken mirror' theory, proposing a specific failure in ASD of the ability of the brain to 'mirror' observed actions, was based on altered μ-wave suppression in ASD but was later questioned both theoretically and empirically, pointing toward a more complex picture of dysfunctional executive functions and visual attention.
“One theory proposing a specific failure in ASD of the ability of the brain to ' mirror ' observed actions of another person (thereby named the 'broken mirror' theory ) was based on altered μ -wave suppression in ASD 93 but was later questioned both theoretically 94,95 and empirically 96,97 , pointing toward a more complex picture of dysfunctional executive functions and visual attention 98”
From Autism spectrum disorder (2020) · cites this paper as [93]
Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1943) · The Nervous child · Cited by 8,870 · see citing works
The Tuberous Sclerosis Complex
Crino, P. B., Nathanson, K. L., & Henske, E. P. (2006) · New England Journal of Medicine · doi:10.1056/nejmra055323 · Cited by 1,793 · see citing works
Practice parameter: Screening and diagnosis of autism
Filipek, P. A., Accardo, P., Ashwal, S., Baranek, G. T., Cook, E. H., Dawson, G., Gordon, B., Gravel, J. S., Johnson, C. P., Kallen, R. J., et al. (2000) · Neurology · doi:10.1212/wnl.55.4.468 · Cited by 1,061 · see citing works
Chronic epilepsy and cognition: A longitudinal study in temporal lobe epilepsy
Helmstaedter, C., Kurthen, M., Lux, S., Reuber, M., & Elger, C. E. (2003) · Annals of Neurology · doi:10.1002/ana.10692 · Cited by 718 · see citing works
Tuchman, R. F., & Rapin, I. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00160-6 · Cited by 713 · see citing works
Subclinical "Electrical Status Epilepticus" Induced by Sleep in Children
Patry, G. (1971) · Archives of Neurology · doi:10.1001/archneur.1971.00480330070006 · Cited by 495 · see citing works
VOLKMAR, F. R., & NELSON, D. S. (1990) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199001000-00020 · Cited by 439 · see citing works
Danielsson, S., Gillberg, I. C., Billstedt, E., Gillberg, C., & Olssøn, I. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.57504.x · Cited by 296 · see citing works
EEG features and epilepsy in patients with autism
Rossi, P. G., Parmeggiani, A., Bach, V., Santucci, M., & Visconti, P. (1995) · Brain and Development · doi:10.1016/0387-7604(95)00019-8 · Cited by 197 · see citing works
The Neuropsychological and Language Profile of Children with Benign Rolandic Epilepsy
Northcott, E., Connolly, A. M., Berroya, A., et al. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.62304.x · Cited by 165 · see citing works
Autism in Tuberous Sclerosis Complex
Gutierrez, G., Smalley, S. L., & Tanguay, P. E. (1998) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1026032413811 · Cited by 116 · see citing works
Autistic Spectrum Disorder: Evaluating a Possible Contributing or Causal Role of Epilepsy
Deonna, T. W., & Roulet, E. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00697.x · Cited by 111 · see citing works
EEG and neurophysiological studies of early infantile autism.
Small, J. G. (1975) · PubMed · Cited by 87 · see citing works
Avoiding the Pitfalls of EEG Interpretation in Childhood Epilepsy
Mizrahi, E. M. (1996) · Epilepsia · doi:10.1111/j.1528-1157.1996.tb06021.x · Cited by 76 · see citing works
Autism and autistic epileptiform regression with occipital spikes
Nass, R. D., Gross, A., & Devinsky, O. (1998) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1998.tb15395.x · Cited by 70 · see citing works
A Neurological Appraisal of Autistic Children: Results of a Western Australian Survey
Gubbay, S. S., Lobascher, M. E., & Kingerlee, P. E. (1970) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1970.tb01935.x · Cited by 68 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lord, C., Brugha, T. S., Charman, T., Cusack, J., Dumas, G., Frazier, T., Jones, E. J. H., Jones, R. M., Pickles, A., State, M. W., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0138-4 · Cited by 1,859 · see citing works
Miller, D. T., Shen, Y., Weiss, L. A., Korn, J., Anselm, I., Bridgemohan, C., Cox, G. F., Dickinson, H., Gentile, J., Harris, D. J., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.059907 · Cited by 427 · see citing works
Altered neural connectivity in excitatory and inhibitory cortical circuits in autism
Zikopoulos, B., & Barbas, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00609 · Cited by 313 · see citing works
Hashemi, E., Ariza, J., Rogers, H., Noctor, S. C., & Martínez-Cerdeño, V. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw021 · Cited by 322 · see citing works
Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder
Rubenstein, J. L. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328336eb13 · Cited by 230 · see citing works
A systematic review of quality of life of adults on the autism spectrum
Ayres, M., Parr, J. R., Rodgers, J., Mason, D., Avery, L., & Flynn, D. (2018) · Autism · doi:10.1177/1362361317714988 · Cited by 230 · see citing works
Cortical variability in the sensory-evoked response in autism
Haigh, S. M., Heeger, D. J., Dinstein, I., Minshew, N., & Behrmann, M. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2276-6 · Cited by 113 · see citing works
Association and mutation analyses of 16p11.2 autism candidate genes
Kumar, R. A., Marshall, C. R., Badner, J. A., Babatz, T. D., Mukamel, Z., Aldinger, K. A., Sudi, J., Brune, C. W., Goh, G., KaraMohamed, S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004582 · Cited by 95 · see citing works
Bumetanide for autism: more eye contact, less amygdala activation
Hadjikhani, N., Åsberg Johnels, J., Lassalle, A., Zürcher, N. R., Hippolyte, L., Gillberg, C., Lemonnier, E., & Ben-Ari, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-21958-x · Cited by 90 · see citing works
The neurochemical basis for the treatment of autism spectrum disorders and Fragile X syndrome
Hampson, D. R., Adusei, D. C., & Pacey, L. K. K. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.005 · Cited by 34 · see citing works
- Authors
- Levisohn, P. M.
- Affiliations
- University of Colorado Denver (US)
- Corresponding author
- Levisohn, Paul M.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2007-11-29
- Volume
- 48
- Issue
- s9
- Pages
- 33-35
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1545240335
- Cited by
- 146
- References
- 16
- Citations by year
- 2025: 4 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 8 · 2018: 26 · 2017: 11 · 2016: 6 · 2015: 8 · 2014: 11 · 2013: 7 · 2012: 7
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, epilepsy, seizures, epileptiform EEG abnormalities, comorbidities, cognitive impairment, language disorders, social dysfunction
- MeSH terms
- Autistic Disorder, Cognition Disorders, Electroencephalography, Epilepsy, Humans, Models, Psychological, Regression, Psychology, Comorbidity, Prevalence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
