Bumetanide for autism: more eye contact, less amygdala activation
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We recently showed that constraining eye contact leads to exaggerated increase of amygdala activation in autism. Here, in a proof of concept pilot study, we demonstrate that administration of bumetanide (a NKCC1 chloride importer antagonist that restores GABAergic inhibition) normalizes the level of amygdala activation during constrained eye contact with dynamic emotional face stimuli in autism. In addition, eye-tracking data reveal that bumetanide administration increases the time spent in spontaneous eye gaze during in a free-viewing mode of the same face stimuli. In keeping with clinical trials, our data support the Excitatory/Inhibitory dysfunction hypothesis in autism, and indicate that bumetanide may improve specific aspects of social processing in autism. Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.
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Functional-MRI-based evidence suggests that bumetanide reduces exaggerated amygdala activation to eye contact in individuals with ASD and contributes to increased eye-gaze time with biological stimuli and better emotional face perception.
“There is some functional-MRI-based evidence suggesting that bumetanide reduces the exaggerated amygdala activation to eye contact in individuals with ASD and contributes to increased eye-gaze time with biological stimuli and better emotional face perception [100, 101].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [100]
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- Authors
- Hadjikhani, N., Åsberg Johnels, J., Lassalle, A., Zürcher, N. R., Hippolyte, L., Gillberg, C., Lemonnier, E., & Ben-Ari, Y.
- Affiliations
- Harvard University (US)
- University of Lausanne (CH)
- University of Gothenburg (SE)
- Corresponding author
- Hadjikhani, Nouchine
- Venue
- Scientific Reports
- Published
- 2018-02-26
- Volume
- 8
- Issue
- 1
- Pages
- 3602-3602
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5827728
- OpenAlex
- W2796602310
- Cited by
- 90
- References
- 63
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 12 · 2022: 14 · 2021: 16 · 2020: 16 · 2019: 9 · 2018: 5
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, cc-by)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- Leiden Repository (Leiden University) (submittedVersion)
- IRIS (submittedVersion, cc-by)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PP00P3, 130191)
- Université de Lausanne
- Centre d'Imagerie BioMédicale
- LifeWatch – Niclas Öberg Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- bumetanide, autism spectrum disorder, amygdala activation, eye contact, GABAergic inhibition, emotional face processing, social gaze, social processing
- MeSH terms
- Adolescent, Adult, Amygdala, Autistic Disorder, Bumetanide, Double-Blind Method, Emotions, Female, Fixation, Ocular, Humans, Male, Magnetic Resonance Spectroscopy, Pilot Projects, Sodium Potassium Chloride Symporter Inhibitors, Young Adult
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