The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Management issues for women with epilepsy—Focus on pregnancy (an evidence‐based review): II. Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurology and the American Epilepsy Society
Abstract
Summary: A committee assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including antiepileptic drug (AED) teratogenicity and adverse perinatal outcomes. It is highly probable that intrauterine first‐trimester valproate (VPA) exposure has higher risk of major congenital malformations (MCMs) compared to carbamazepine (CBZ), and possibly compared to phenytoin (PHT) or lamotrigine (LTG). It is probable that VPA as part of polytherapy and possible that VPA as monotherapy contribute to the development of MCMs. AED polytherapy probably contributes to the development of MCMs and reduced cognitive outcomes compared to monotherapy. Intrauterine exposure to VPA monotherapy probably reduces cognitive outcomes and monotherapy exposure to PHT or phenobarbital (PB) possibly reduces cognitive outcomes. Neonates of WWE taking AEDs probably have an increased risk of being small for gestational age and possibly have an increased risk of a 1‐minute Apgar score of <7. If possible, avoidance of VPA and AED polytherapy during the first trimester of pregnancy should be considered to decrease the risk of MCMs. If possible, avoidance of VPA and AED polytherapy throughout pregnancy should be considered and avoidance of PHT and PB throughout pregnancy may be considered to prevent reduced cognitive outcomes.
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Cites
Agresti, A. (2002) · Wiley Series in Probability and Statistics · doi:10.1002/0471249688 · Cited by 6,746
How common are the "common" neurologic disorders?
Hirtz, D., Thurman, D. J., Gwinn-Hardy, K., Mohamed, M., Chaudhuri, A. R., & Zalutsky, R. (2007) · Neurology · doi:10.1212/01.wnl.0000252807.38124.a3 · Cited by 1,365
Self-citationHOW COMMON ARE THE “COMMON” NEUROLOGIC DISORDERS?
Kaplin, A. I., & Williams, M. (2007) · Neurology · doi:10.1212/01.wnl.0000278071.91524.4d · Cited by 1,131
Marson, A. G., Al-Kharusi, A. M., Alwaidh, M., Appleton, R., Baker, G. A., Chadwick, D. W., Cramp, C., Cockerell, O. C., Cooper, P. N., Doughty, J., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60461-9 · Cited by 969
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The Teratogenicity of Anticonvulsant Drugs
Holmes, L. B., Harvey, E. A., Coull, B. A., Huntington, K. B., Khoshbin, S., Hayes, A. M., & Ryan, L. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441504 · Cited by 655
Self-citationThe longer term outcome of children born to mothers with epilepsy
Adab, N. (2004) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.029132 · Cited by 580
Samrén, E. B., van Duijn, C. M., Koch, S., Hiilesmaa, V. K., Klepel, H., Bardy, A. H., Mannagetta, G. B., Deichl, A. W., Gaily, E., Granström, I. L., et al. (1997) · Epilepsia · doi:10.1111/j.1528-1157.1997.tb01480.x · Cited by 406
Increased rate of major malformations in offspring exposed to valproate during pregnancy
Wyszynski, D. F., Nambisan, M., Surve, T., Alsdorf, R. M., Smith, C. R., & Holmes, L. B. (2005) · Neurology · doi:10.1212/01.wnl.0000154516.43630.c5 · Cited by 390
Self-citationAntiepileptic drug use of women with epilepsy and congenital malformations in offspring
Artama, M., Auvinen, A., Raudaskoski, T., Isojärvi, I., & Isojärvi, J. (2005) · Neurology · doi:10.1212/01.wnl.0000163771.96962.1f · Cited by 305
Cited by
Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations
Jentink, J., Loane, M. A., Dolk, H., Barisic, I., Garne, E., Morris, J. K., & de Jong-van den Berg, L. T. W. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907328 · Cited by 587
The pharmacological treatment of epilepsy in adults
Perucca, E., & Tomson, T. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70047-3 · Cited by 334
Drug treatment of epilepsy in adults
Schmidt, D., & Schachter, S. C. (2014) · BMJ · doi:10.1136/bmj.g254 · Cited by 323
Antiepileptic drugs and pregnancy outcomes
Wlodarczyk, B. J., Palacios, A. M., George, T. M., & Finnell, R. H. (2012) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35438 · Cited by 138
Self-citationNeurodevelopmental effects of fetal antiepileptic drug exposure
Velez-Ruiz, N. J., & Meador, K. J. (2015) · Drug Safety · doi:10.1007/s40264-015-0269-9 · Cited by 48
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Metadata
- Authors
- Harden, C. L., Meador, K. J., Pennell, P. B., Allen Hauser, W., Gronseth, G. S., French, J. A., Wiebe, S., Thurman, D., Koppel, B. S., Kaplan, P. W., Robinson, J. N., Hopp, J., Ting, T. Y., Gidal, B., Hovinga, C. A., Wilner, A. N., Vazquez, B., Holmes, L., Krumholz, A., Finnell, R., Hirtz, D., & Le Guen, C.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2009-05
- Volume
- 50
- Issue
- 5
- Pages
- 1237-1246
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W2075852519
- Cited by
- 255
- References
- 41
- FWCI
- 21.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Management issues for women with epilepsy—Focus on pregnancy (an evidence‐based review): II. Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurology and the American Epilepsy Society. https://app.cochat.ai/papers/10.1111/j.1528-1167.2009.02129.x
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- Harden, C. L., Meador, K. J., Pennell, P. B., Allen Hauser, W., Gronseth, G. S., French, J. A., Wiebe, S., Thurman, D., Koppel, B. S., Kaplan, P. W., Robinson, J. N., Hopp, J., Ting, T. Y., Gidal, B., Hovinga, C. A., Wilner, A. N., Vazquez, B., Holmes, L., Krumholz, A., . . . Le Guen, C. (2009). Management issues for women with epilepsy—Focus on pregnancy (an evidence‐based review): II. Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Epilepsia. https://doi.org/10.1111/j.1528-1167.2009.02129.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
