The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Drug treatment of epilepsy in adults
Abstract
Epilepsy is a serious, potentially life shortening brain disorder, the symptoms of which can be successfully treated in most patients with one or more antiepileptic drug. About two in three adults with new onset epilepsy will achieve lasting seizure remission on or off these drugs, although around half will experience mild to moderately severe adverse effects. Patients with epilepsy, especially the 20-30% whose seizures are not fully controlled with available drugs (drug resistant epilepsy), have a significantly increased risk of death, as well as psychiatric and somatic comorbidities, and adverse effects from antiepileptic drugs. Newer drugs have brought more treatment options, and some such as levetiracetam cause fewer drug interactions and less hypersensitivity than older ones. However, they do not reduce the prevalence of drug resistant epilepsy or prevent the development of epilepsy in patients at high risk, such as those with a traumatic brain injury. The development of antiepileptic drugs urgently needs to be revitalized so that we can discover more effective antiseizure drugs for the treatment of drug resistant epilepsy, including catastrophic forms. Antiepileptogenic agents to prevent epilepsy before the first seizure in at risk patients and disease modifying agents to control ongoing severe epilepsy associated with progressive underlying disease are also needed.
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Cites
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Early Identification of Refractory Epilepsy
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Kwan, P., Arzimanoglou, A., Berg, A. T., Brodie, M. J., Allen Hauser, W., Mathern, G., Moshé, S. L., Perucca, E., Wiebe, S., & French, J. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2009.02397.x · Cited by 4,877
Berg, A. T., Berkovic, S. F., Brodie, M. J., Buchhalter, J., Cross, J. H., Van Emde Boas, W., Engel, J., French, J., Glauser, T. A., Mathern, G. W., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02522.x · Cited by 4,363
Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma
WOTHERSPOON, A. (1991) · The Lancet · doi:10.1016/0140-6736(91)92035-z · Cited by 1,866
Estimation of the burden of active and life-time epilepsy: a meta-analytic approach
Ngugi, A. K., Bottomley, C., Kleinschmidt, I., Sander, J. W., & Newton, C. R. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2009.02481.x · Cited by 1,447
The neurobiology of antiepileptic drugs
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Mattson, R. H., Cramer, J. A., Collins, J. F., Smith, D. B., Delgado-Escueta, A. V., Browne, T. R., Williamson, P. D., Treiman, D. M., McNamara, J. O., McCutchen, C. B., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507183130303 · Cited by 1,138
HOW COMMON ARE THE “COMMON” NEUROLOGIC DISORDERS?
Kaplin, A. I., & Williams, M. (2007) · Neurology · doi:10.1212/01.wnl.0000278071.91524.4d · Cited by 1,131
Cited by
Diagnostic challenges in epilepsy: seizure under-reporting and seizure detection
Elger, C. E., & Hoppe, C. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30038-3 · Cited by 403
Targeting receptor-ligand chemistry for drug delivery across blood-brain barrier in brain diseases
Anthony, D. P., Hegde, M., Shetty, S. S., Rafic, T., Mutalik, S., & Rao, B. S. S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119326 · Cited by 110
Hill, T., Coupland, C., Morriss, R., Arthur, A., Moore, M., & Hippisley-Cox, J. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0701-9 · Cited by 91
Tau deposition in young adults with drug-resistant focal epilepsy.
Smith, K. M., Blessing, M. M., Parisi, J. E., Britton, J. W., Mandrekar, J., & Cascino, G. D. (2019) · Epilepsia · doi:10.1111/epi.16375 · Cited by 42
Bloechliger, M., Ceschi, A., Rüegg, S., Kupferschmidt, H., Kraehenbuehl, S., Jick, S. S., Meier, C. R., & Bodmer, M. (2016) · Drug Safety · doi:10.1007/s40264-015-0363-z · Cited by 40
Metadata
- Authors
- Schmidt, D., & Schachter, S. C.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2014-02-28
- Volume
- 348
- Issue
- feb28 2
- Pages
- g254-g254
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W2077008944
- Cited by
- 323
- References
- 114
- FWCI
- 22.23
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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