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Alcohol and drugs in epilepsy: Pathophysiology, presentation, possibilities, and prevention
Abstract
Summary: The potentially serious outcomes from ingestion of and dependence on toxins make this an important topic for epileptologists. We must be aware of the potential for harm from compounds that may be freely available, yet patients may try to conceal their use. Problematic compounds may cause seizures either acutely or on withdrawal: Their use may reduce effectiveness of antiepileptic drugs, or may simply promote and enhance chaotic lifestyles. Any or all of these factors may worsen seizure control or even directly cause seizures. This article highlights the pathophysiology behind provoked seizures, provides clues to diagnosis, and then outlines the steps that clinicians should take to reduce the deleterious effects of toxic compounds.
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“In addition, alcohol use may affect the clinical course of pre‐existing epilepsy either by changes in anti‐epileptic drug pharmacokinetics or by non‐compliance with prescribed medication 236, 237.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [237]
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Metadata
- Authors
- Leach, J. P., Mohanraj, R., & Borland, W.
- Affiliations
- Southern General Hospital (GB)
- Salford Royal Hospital (GB)
- Gartnavel General Hospital (GB)
- Corresponding author
- Leach, John Paul
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2012-09
- Volume
- 53
- Issue
- s4
- Pages
- 48-57
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1553610755
- Cited by
- 105
- References
- 91
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 21 · 2020: 11 · 2019: 4 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 2 · 2012: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- alcohol, drugs, epilepsy, provoked seizures, substance use, withdrawal seizures, antiepileptic drug interactions, seizure control, pathophysiology, prevention, diagnosis
- MeSH terms
- Alcohol Drinking, Ethanol, Alcoholism, Benzodiazepines, Marijuana Abuse, Central Nervous System Depressants, Epilepsy, gamma-Aminobutyric Acid, Heroin Dependence, Humans, Ketamine, Seizures, Substance-Related Disorders, Amphetamine-Related Disorders, Cocaine-Related Disorders, Alcohol Withdrawal Seizures
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