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Cited by 95Substance Abuse Treatment and OutcomesAlcohol Consumption and Health EffectsChild and Adolescent Psychosocial and Emotional Development

Health problems in adolescents with alcohol use disorders: self-report, liver injury, and physical examination findings and correlates

Clark, Duncan B., Lynch, Kevin G., Donovan, John E., Block, Geoffrey D.·2001·Alcoholism Clinical and Experimental Research
DOI 10.1111/j.1530-0277.2001.tb02358.x
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Abstract

BACKGROUND: Although adolescent alcohol consumption has been found to be positively correlated with self-reported health problems, few studies have examined other health indicators. This study compared adolescents with alcohol use disorders (AUDs) and a community reference group on self-reported health problems, serum liver enzymes, and physical examination findings. The relevance of negative emotionality to understanding these health problems was also investigated. METHODS: The subjects were adolescents with AUDs recruited from clinical programs and classified as having DSM-IV alcohol dependence (n = 71) or alcohol abuse (n = 57) and reference adolescents without AUDs recruited from community sources (n = 131). The assessment of health status included self-reported health problems in 15 areas; serum liver enzyme assays, including gamma-glutamyl transpeptidase, alanine aminotransferase, and aspartate aminotransferase; and physical examination findings. Negative emotionality was determined by systematically combining scores from the Hamilton Anxiety Rating Scale, the Beck Depression Inventory, the Child Behavior Checklist, and the Multidimensional Personality Questionnaire. RESULTS: Adolescent AUDs were associated with more self-reported health problems, higher gamma-glutamyl transpeptidase and alanine aminotransferase levels, and more physical examination abnormalities. Negative emotionality was highly correlated with self-reported health problems, mediated the relationship between AUDs and self-reported health problems, and was not correlated with serum liver enzyme levels or physical examination abnormalities. CONCLUSIONS: These results indicated that AUDs during adolescence were associated with health problems, including modest but demonstrable liver injury. Self-reported health problems were probably best understood, in this context, as a negative emotionality manifestation.

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  • Self-reported sleep problems were significantly associated with AUD, negative emotionality, and tobacco involvement, and the association between AUD and sleep problems remained statistically significant after controlling for negative emotionality and tobacco involvement.

    “Comparing adolescents with AUDs and a reference group, Clark and colleagues (Clark, Lynch, Donovan, & Block, 2001) found self-reported sleep problems (5 items) to be significantly associated with AUD, negative emotionality, and tobacco involvement. The association between AUD and sleep problems remained statistically significant after controlling for negative emotionality and tobacco involvement.”

    From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Clark et al., 2001

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Authors
Clark, D. B., Lynch, K. G., Donovan, J. E., & Block, G. D.
Affiliations
University of Pittsburgh (US)
Corresponding author
Clark, Duncan B.
ORCID
Venue
Alcoholism Clinical and Experimental Research
Publisher
Wiley
Published
2001-09
Volume
25
Issue
9
Pages
1350-1359
ISSN
  • 0145-6008 (ISSN-L)
  • 1530-0277
DOI
10.1111/j.1530-0277.2001.tb02358.x
OpenAlex
W2063764105
Cited by
95
References
66
Citations by year
2022: 1 · 2021: 1 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 3 · 2013: 6 · 2012: 10
FWCI
4.05
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1683 d)
Locations
  • Alcoholism Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical Center, University of Pittsburgh
  • National Institute on Alcohol Abuse and Alcoholism (P50-AA 08746, P50AA008746, K02AA000291, K02-AA00291)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
adolescent alcohol use disorders, alcoholism, alcohol abuse, self-reported health problems, liver injury, liver enzymes, gamma-glutamyl transferase, alanine aminotransferase, negative affectivity, anxiety, depression
MeSH terms
Adolescent, Affective Symptoms, Alanine Transaminase, Alcoholism, Female, gamma-Glutamyltransferase, Health Status, Humans, Liver, Liver Diseases, Alcoholic, Male, Physical Examination, Plants, Toxic, Nicotiana, Alcohol-Related Disorders

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