The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Cytokines and Alcohol
Abstract
Cytokines are multifunctional proteins that play a critical role in cellular communication and activation. Cytokines have been classified as being proinflammatory (T helper 1, Th1) or anti‐inflammatory (T helper 2, Th2) depending on their effects on the immune system. However, cytokines impact a variety of tissues in a complex manner that regulates inflammation, cell death, and cell proliferation and migration as well as healing mechanisms. Ethanol (alcohol) is known to alter cytokine levels in a variety of tissues including plasma, lung, liver, and brain. Studies on human monocyte responses to pathogens reveal ethanol disruption of cytokine production depending upon the pathogen and duration of alcohol consumption, with multiple pathogens and chronic ethanol promoting inflammatory cytokine production. In lung, cytokine production is disrupted by ethanol exacerbating respiratory distress syndrome with greatly increased expression of transforming growth factor β (TGF β). Alcoholic liver disease involves an inflammatory hepatitis and an exaggerated Th1 response with increases in tumor necrosis factor α (TNF α). Recent studies suggest that the transition from Th1 to Th2 cytokines contribute to hepatic fibrosis and cirrhosis. Cytokines affect the brain and likely contribute to changes in the central nervous system that contribute to long‐term changes in behavior and neurodegeneration. Together these studies suggest that ethanol disruption of cytokines and inflammation contribute in multiple ways to a diversity of alcoholic pathologies.
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Cites
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Cytokine-induced sickness behavior
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Self-citationCharacterization of tumor necrosis factor-deficient mice
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Cited by
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144
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Self-citationMarjot, T., Moon, A. M., Cook, J. A., Abd-Elsalam, S., Aloman, C., Armstrong, M. J., Pose, E., Brenner, E. J., Cargill, T., Catana, M.-A., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2020.09.024 · Cited by 518
Rehm, J., Samokhvalov, A. V., Neuman, M. G., Room, R., Parry, C., Lönnroth, K., Patra, J., Poznyak, V., & Popova, S. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-450 · Cited by 458
Smoking and increased Alzheimer's disease risk: A review of potential mechanisms
Durazzo, T. C., Mattsson, N., Weiner, M. W., & Initiative, A. D. N. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.04.009 · Cited by 451
Metadata
- Authors
- Crews, F. T., Bechara, R., Brown, L. A., Guidot, D. M., Mandrekar, P., Oak, S., Qin, L., Szabo, G., Wheeler, M., & Zou, J.
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2006-03-29
- Volume
- 30
- Issue
- 4
- Pages
- 720-730
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- OpenAlex
- W2154698170
- Cited by
- 406
- References
- 53
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Crews, F. T., Bechara, R., Brown, L. A., Guidot, D. M., Mandrekar, P., Oak, S., Qin, L., Szabo, G., Wheeler, M., & Zou, J. (2006). Cytokines and Alcohol. Alcoholism: Clinical and Experimental Research. https://doi.org/10.1111/j.1530-0277.2006.00084.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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