Role of Stress in Acquisition of Alcohol‐Conditioned Place Preference in Adolescent and Adult Mice
Abstract
Background: Both clinical evidence and findings from animal models demonstrate that there are differences between adolescents and adults in alcohol dependence. As stress plays a critical role in processes of alcohol addiction, we tested whether stress is involved in alcohol vulnerability differently during adolescence and adulthood in mice. Methods: To determine whether age differences exist in the acquisition of alcohol‐conditioned place preference (CPP) in mice, adolescent and adult mice were trained for CPP with different doses of alcohol (0, 0.5, 1, and 2 g/kg, i.p.). To explore the effects of stress (footshock) on acquisition of alcohol CPP in mice of different ages, adolescent and adult mice underwent acute (1 day) or chronic (1 week) stress before CPP training. Acquisition of CPP was examined after the CPP training. Results: Under nonstress conditions, adult mice acquired alcohol CPP when trained with 2 g/kg alcohol, while adolescent mice did not acquire alcohol CPP. After chronic but not acute stress exposure, adolescent mice acquired significant CPP trained with 2 g/kg alcohol that did not produce CPP under nonstress conditions. However, stress did not have significant effect on acquisition of CPP in adult mice trained CPP with 1 g/kg alcohol. Conclusions: These results indicate that there is an age difference in acquiring alcohol CPP and adolescent mice are more sensitive than adults to stress.
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Repeated stress during adolescence increases the incentive value and attraction to contexts previously paired with either nicotine or alcohol, even at lower doses.
“Repeated stress during adolescence has also been shown to increase the incentive value and attraction to contexts previously paired with either nicotine or alcohol, even at lower doses (Brielmaier, McDonald, & Smith, 2012; Song et al., 2007).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Song et al., 2007
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- Authors
- Song, M., Wang, X., Zhao, M., Wang, X., Zhai, H., & Lu, L.
- Affiliations
- Hebei Medical University (CN)
- ORCID
- Song, Mei
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2007-10-19
- Volume
- 31
- Issue
- 12
- Pages
- 2001-2005
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- OpenAlex
- W2090566158
- Cited by
- 59
- References
- 37
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 1 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- stress, adolescent mice, adult mice, age differences, chronic stress, acute stress, footshock, alcoholism
- MeSH terms
- Age Factors, Alcohol Drinking, Ethanol, Alcoholism, Animals, Association Learning, Choice Behavior, Conditioning, Classical, Dose-Response Relationship, Drug, Electroshock, Fear, Female, Injections, Intraperitoneal, Male, Social Environment, Stress, Psychological, Mice
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