The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial
Open accessAbstract
BACKGROUND: Trazodone is a commonly prescribed off-label for sleep disturbance in alcohol-dependent patients, but its safety and efficacy for this indication is unknown. METHODS: We conducted a randomized, double-blind, placebo-control trial of low-dose trazodone (50 to 150 mg at bedtime) for 12 weeks among 173 alcohol detoxification patients who reported current sleep disturbance on a validated measure of sleep quality or during prior periods of abstinence. Primary outcomes were the proportion of days abstinent and drinks per drinking day over 6-months; sleep quality was also assessed. RESULTS: Urn randomization balanced baseline features among the 88 subjects who received trazodone and 85 who received placebo. The trazodone group experienced less improvement in the proportion of days abstinent during administration of study medication (mean change between baseline and 3 months: -0.12; 95% CI: -0.15 to -0.09), and an increase in the number of drinks per drinking day on cessation of the study medication (mean change between baseline and 6 months, 4.6; 95% CI: 2.1 to 7.1). Trazodone was associated with improved sleep quality during its administration (mean change on the Pittsburgh Sleep Quality Index between baseline and 3 months: -3.02; 95% CI: -3.38 to -2.67), but after it was stopped sleep quality equalized with placebo. CONCLUSIONS: Trazodone, despite a short-term benefit on sleep quality, might impede improvements in alcohol consumption in the postdetoxification period and lead to increased drinking when stopped. Until further studies have established benefits and safety, routine initiation of trazodone for sleep disturbance cannot be recommended with confidence during the period after detoxification from alcoholism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“While some of the pharmacological intervention studies may have been underpowered to detect secondary outcomes, Friedmann and colleagues (2008) were sufficiently powered to detect changes in abstinence as a function of treatment and did document improvements in sleep quality as a result of treatment with trazodone.”
From Insomnia treatment in the context of alcohol use disorder: A systematic review and meta-analysis (2017) · cites this paper as Friedmann et al., 2008
In the citing paper
“While some of the pharmacological intervention studies may have been underpowered to detect secondary outcomes, Friedmann and colleagues (2008) were sufficiently powered to detect changes in abstinence as a function of treatment and did document improvements in sleep quality as a result of treatment with trazodone.”
From Insomnia treatment in the context of alcohol use disorder: A systematic review and meta-analysis (2017) · cites this paper as Friedmann et al., 2008
In the citing paper
“However, their sample also consisted of recently detoxified patients, only 25% of whom had engaged in formal substance use treatment by one-month follow-up.”
From Insomnia treatment in the context of alcohol use disorder: A systematic review and meta-analysis (2017) · cites this paper as Friedmann et al., 2008
In the citing paper
“However, in contrast to hypotheses, they found that participants in the trazodone group reported a smaller increase in abstinent days than those in the placebo group.”
From Insomnia treatment in the context of alcohol use disorder: A systematic review and meta-analysis (2017) · cites this paper as Friedmann et al., 2008
In the citing paper
“Adult sleep treatment studies in recovering drinkers consistently report improvements in sleep, but either indeterminate effects on alcohol outcomes in cognitive-behavioral treatment studies (Arnedt et al., 2007; Arnedt, Conroy, Armitage, & Brower, 2011; Currie, Clark, Hodgins, & El-Guebaly, 2004) or worse alcohol outcomes following pharmacological treatment (Friedmann et al., 2008).”
From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Friedmann et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,421
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
Analysis of Incomplete Multivariate Data
Schafer, J. L. (1997) · doi:10.1201/9781439821862 · Cited by 6,012
Analysis of Incomplete Multivariate Data
Booth, D. E., & Schafer, J. L. (2000) · Technometrics · doi:10.2307/1271466 · Cited by 5,627
Sobell, L. C., & Sobell, M. B. (1992) · Measuring Alcohol Consumption · doi:10.1007/978-1-4612-0357-5_3 · Cited by 4,110
Psychometric evaluation of the pittsburgh sleep quality index
Carpenter, J. S., & Andrykowski, M. A. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00298-5 · Cited by 1,618
Monk, T. H., Reynolds, C. F., Kupfer, D. J., Buysse, D. J., Coble, P. A., HAYES, A. J., Machen, M. A., PETRIE, S. R., & Ritenour, A. (1994) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1994.tb00114.x · Cited by 537
Truth or consequences: the validity of self‐report data in health services research on addictions
Boca, F. K. D., & Noll, J. A. (2000) · Addiction · doi:10.1046/j.1360-0443.95.11s3.5.x · Cited by 468
Research works printed but not linked: 5
- American Sleep Disorders Association, 1997, Sleep Hygiene. Behaviors that Help Promote Sound Sleep
- Beck AT, 1996, Manual for Beck Depression Inventory‐II
- First M, 1995, Structured Clinical Interview for DSM‐IV – Patient Version
- Hedeker D, 1999, RMASS2: Repeated Measures with Attrition: Sample Sizes for 2 Groups [Computer software]
- Ware JE, 1995, How to Score the SF‐12 Physical & Mental Health Summary Scales
Cited by
Sorted by citations
Items 101–116 of 116
Substance-related disorders and sleep
Reffi, A. N., Kolla, B. P., Graham, M., Cardoni, M. E., Amin, S., Conroy, D. A., & Arnedt, J. T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00086-4
Substance and Alcohol-Related Disorders and Sleep
Arnedt, J. T., & Conroy, D. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-378610-4.00481-2
Der Zusammenhang zwischen Sucht und Schlaf: „Illegale“ Drogen
Jähne, A., Unbehaun, T., & Riemann, D. W. (2013) · SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice · doi:10.1024/0939-5911.a000234
Insomnia in addictive diseases and treatment of insomnia in opiate withdrawal crisis
Dickov, A. (2022) · Galenika Medical Journal · doi:10.5937/galmed2203016d
Troubles du sommeil et addictions
Mauries, S., Tebeka, S., & Geoffroy, P. A. (2023) · Elsevier eBooks · doi:10.1016/b978-2-294-77934-3.00044-5
Wood, E., Bright, J., Hsu, K., Goel, N., Ross, J. W. G., Hanson, A., Teed, R., Poulin, G., Denning, B., Corace, K., et al. (2024) · Canadian Medical Association Journal · doi:10.1503/cmaj.230715-f
Bahji, A., Danilewitz, M., Sloan, M. E., Tang, V. M., & Crockford, D. N. (2024) · Canadian Medical Association Journal · doi:10.1503/cmaj.149917-l-f
Wood, E., & Rehm, J. T. (2024) · Canadian Medical Association Journal · doi:10.1503/cmaj.150095-l-f
Elefante, R. J. O., Lu, C., & Bach, P. (2024) · Canadian Medical Association Journal · doi:10.1503/cmaj.150034-l-f
Sleep in Patients With Substance Use Disorders
Cardoni, M. E., Kolla, B. P., Graham, M., Bronsteyn, Y., & Arnedt, J. T. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197602751.013.31
Chakravorty, S., Mills, A., Hayes, K., & Krouse, R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13954-3.00046-2
Avoiding anticholinergic burden in neuropsychiatric treatments comorbid with alcohol use disorder
Segura-Ulate, I. (2025) · Dementia & Neuropsychologia · doi:10.1590/1980-5764-dn-2025-0342
Urbano, F. J., Bisagno, V., & García‐Rill, E. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801385-4.00013-6
Redden, W. M., & Jones, A. M. (2026) · Springer eBooks · doi:10.1007/978-3-032-15772-0_6
Implementing Evidence-Based Care for Alcohol Use Disorder
Hadland, S. E., Dennis, B. B., & Wood, E. (2026) · NEJM Evidence · doi:10.1056/evidra2500065
Wood, E., Rehm, J. T., Perry, T. L., Menkes, D. B., Poulin, G., Lim, R., Healy, D., Foll, B. L., & Bruneau, J. (2026) · The Canadian Journal of Psychiatry · doi:10.1177/07067437261468911
Metadata
- Authors
- Friedmann, P. D., Rose, J. S., Swift, R., Stout, R. L., Millman, R. P., & Stein, M. D.
- Affiliations
- Brown University (US)
- Corresponding author
- Friedmann, Peter D.
- ORCID
- Venue
- Alcoholism Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2008-08-25
- Volume
- 32
- Issue
- 9
- Pages
- 1652-1660
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- PMC
- PMC2567128
- OpenAlex
- W2091013876
- Cited by
- 116
- References
- 42
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 12 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 13 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 4
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA13243, R01AA013243)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- trazodone, sleep disorders, alcohol detoxification, alcoholism, sleep quality, alcohol abstinence, relapse, off-label drug use
- MeSH terms
- Adult, Ethanol, Alcoholism, Central Nervous System Depressants, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Inactivation, Metabolic, Middle Aged, Sleep Wake Disorders, Anti-Anxiety Agents, Trazodone, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
