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Cited by 102Sleep and related disordersSubstance Abuse Treatment and OutcomesAlcoholism and Thiamine Deficiency

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Double-Blind, Placebo-Controlled Study of the Efficacy of Trazodone in Alcohol Post-Withdrawal Syndrome: Polysomnographic and Clinical Evaluations

Le Bon, Olivier, Murphy, James R., Staner, Luc, Hoffmann, Guy, Kormoss, Nicolas, Kentos, Monique, Dupont, Philippe, Lion, Karin, Pelc, Isidore, Verbanck, Paul·2003·Journal of Clinical Psychopharmacology
DOI 10.1097/01.jcp.0000085411.08426.d3
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Abstract

Alcohol detoxification is accompanied by sustained difficulties in sleep initiation and maintenance. These difficulties are thought to be an important cause of relapse to alcohol use. However, the treatment of sleep problems with hypnotic drug is made difficult by cross-tolerance between benzodiazepines and alcohol. In this report, we evaluated the capacity of trazodone (TRZ), a second-generation antidepressant with anxiolytic and sedative properties, to increase the sleep efficiency in alcohol-dependent patients after detoxification. Sixteen patients completed the TRZ (n = 8) or the placebo (PL; n = 8) treatment arms. Polysomnographies were performed at baseline, after the 1st drug dose, and after 4 weeks of treatment. The main outcome was sleep efficiency. Secondary outcomes included changes in other sleep parameters, Hamilton Depression Rating and Clinical Global Impression scales. Sleep efficiency was increased in the TRZ group when it was computed after sleep onset, both immediately after 1st administration of the drug and after 4 weeks of treatment. No benefit was observed in the PL group. Sleep improvement under TRZ also included the number of awakenings, intermittent wake sleep time, and non-rapid eye movement sleep. Hamilton and Clinical Global scales were better for the TRZ group. TRZ is thus a potential option in the treatment of alcohol post-withdrawal insomnia.

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  • Trazodone (100mg) was associated with significantly better sleep efficiency and significantly less nocturnal disturbance than placebo in alcohol dependent patients.

    “(Le Bon et al., 2003) showed that trazodone (100mg) was associated with significantly better sleep efficiency and significantly less nocturnal disturbance than placebo in alcohol dependent patients.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Le Bon et al., 2003

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Metadata

Authors
Le Bon, O., Murphy, J. R., Staner, L., Hoffmann, G., Kormoss, N., Kentos, M., Dupont, P., Lion, K., Pelc, I., & Verbanck, P.
Affiliations
Université Libre de Bruxelles (BE)
Corresponding author
  • Hoffmann, Guy
  • Kentos, Monique
  • Dupont, Philippe
  • Lion, Karin
  • Pelc, Isidore
  • Verbanck, Paul
ORCID
Murphy, James R.
Venue
Journal of Clinical Psychopharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-08
Volume
23
Issue
4
Pages
377-383
ISSN
0271-0749 (ISSN-L)
DOI
10.1097/01.jcp.0000085411.08426.d3
OpenAlex
W2089052050
Cited by
102
References
0
Citations by year
2025: 4 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 10 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 4
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords
trazodone, alcohol withdrawal, sleep efficiency, alcoholism, alcohol detoxification, polysomnography, relapse prevention
MeSH terms
Adolescent, Adult, Aged, Ethanol, Alcoholism, Central Nervous System Depressants, Double-Blind Method, Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Substance Withdrawal Syndrome, Trazodone, Polysomnography, Antidepressive Agents, Second-Generation

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