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Gastric Emptying Rate in the Elderly: Implications for Drug Therapy
Abstract
ABSTRACT: The effect of the aging process on gastric emptying was studied in 11 elderly subjects (mean age, 77) and in 7 young healthy volunteers (mean age, 26). Gastric emptying rates were assessed by a modified sequential scintiscanning technique after administration of the nonabsorbable chelated radiopharmaceutical 99m Tc‐DTPA. The rate of emptying, expressed as half‐time (T 1/2e ) in minutes, was significantly longer (p < 0.001) in the elderly subjects (mean apparent T 1/2e = 123.23 min) compared to the young healthy volunteers (mean apparent T 1/2e = 49.69 min). Clinical implications of these findings are discussed, particularly with respect to the rate and extent of drug absorption in elderly persons.
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Citations
Cited by
Mangoni, A. A., & Jackson, S. H. D. (2004) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.02007.x · Cited by 1,874
Aging Biology and Geriatric Clinical Pharmacology
McLean, A. J., & Le Couteur, D. G. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.4 · Cited by 771
Greenblatt (1982) · doi:10.1056/nejm198205063061804 · Cited by 584
Nutrition and Aging: Changes in the Regulation of Energy Metabolism With Aging
Roberts, S. B., & Rosenberg, I. (2006) · Physiological Reviews · doi:10.1152/physrev.00019.2005 · Cited by 364
Aging and dyslipidemia: A review of potential mechanisms
Liu, H.-H., & Li, J.-J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.12.001 · Cited by 274
Metadata
- Authors
- EVANS, M. A., TRIGGS, E. J., CHEUNG, M., BROE, G. A., & CREASEY, H.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 1981-05
- Volume
- 29
- Issue
- 5
- Pages
- 201-205
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2057426066
- Cited by
- 170
- References
- 0
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- EVANS, M. A., TRIGGS, E. J., CHEUNG, M., BROE, G. A., & CREASEY, H. (1981). Gastric Emptying Rate in the Elderly: Implications for Drug Therapy. Journal of the American Geriatrics Society. https://doi.org/10.1111/j.1532-5415.1981.tb01766.x
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