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Cited by 143Neutrophil, Myeloperoxidase and Oxidative MechanismsGenetics, Aging, and Longevity in Model OrganismsImmune Response and Inflammation

Polymorphonuclear Functions and Aging in Humans*

Corberand, Joël, Ngyen, Françoise, Laharrague, Patrick, Fontanilles, Anne Marie, Gleyzes, Bernard, Gyrard, Elisabeth, Senegas, Chantal·1981·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.1981.tb02376.x
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Abstract

To determine whether normal aging interferes with the functional capability of polymorphonuclear leukocytes (PMNs), 6 tests of PMN function were performed in 285 healthy subjects whose ages ranged from 20 to 97 years. A second selection based upon blood measurements and a review of medical histories 6 months later, eliminated 68 subjects. The 217 remaining persons were sub‐classed by age into 7 groups including equal numbers of males and females. The functional properties of PMNs in the aged, when compared to those of younger adults, were characterized by: (a) a decrease in the chemotactic response in the 80+ age group; (b) increased adherence, with onset after age 70, maximal after age 80; (c) a progressive decrease of NBT dye reduction capability, up to age 70–79, followed by an unexplained increase of the mean value after age 80; (d) diminished Candida‐killing activity, appearing in the 60+ group and becoming lowest in the oldest group; and (e) lack of changes in spontaneous migration and endocytosis. The mechanisms by which this impairment occurs are hypothetical. It is proposed that normal PMNs, after leaving the bone marrow, are influenced by various humoral components such as metabolic byproducts or immune processes altered by aging. Thus the defective PMN may represent only another victim of the aging process.

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Crossref · 10.1111/j.1532-5415.1981.tb02376.x

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  • Although the number of circulating neutrophils is preserved in older persons, a decrease in CD16 expression results in augmented superoxide generation and impaired neutrophil-mediated phagocytosis.

    “Although the number of circulating neutrophils is preserved in older persons, a decrease in CD16 expression results in augmented superoxide generation and impaired neutrophil-mediated phagocytosis (120, 121).”

    From Aging and Lung Disease (2020) · cites this paper as [121]

  • In healthy older adults, there is an increased proportion of neutrophils and a lower percentage of macrophages present in bronchoalveolar lavage (BAL) fluids.

    “In healthy older adults, there is an increased proportion of neutrophils and a lower percentage of macrophages present in bronchoalveolar lavage (BAL) fluids (121).”

    From Aging and Lung Disease (2020) · cites this paper as [121]

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Authors
Corberand, J., Ngyen, F., Laharrague, P., Fontanilles, A. M., Gleyzes, B., Gyrard, E., & Senegas, C.
Affiliations
  • Groupe d'Etude de la Phagocytose, Laboratoire d'Hématologie Centre Hospitalier Universitaire de Toulouse‐Rangueil et Unité 100 de l'Inserm Toulouse‐Purpan France
  • Inserm (FR)
ORCID
Laharrague, Patrick
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
1981-09
Volume
29
Issue
9
Pages
391-397
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.1981.tb02376.x
OpenAlex
W2069508259
Cited by
143
References
27
Citations by year
2026: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
0.84
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 12291 d)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
polymorphonuclear leukocytes, neutrophil function, aging, chemotaxis, leukocyte adhesion, nitroblue tetrazolium reduction, spontaneous migration, endocytosis, age-related immune decline
MeSH terms
Adult, Aged, Aging, Candida, Cell Adhesion, Chemotaxis, Leukocyte, Female, Humans, Male, Middle Aged, Neutrophils, Nitroblue Tetrazolium, Oxidation-Reduction, Phagocytosis, In Vitro Techniques

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