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Cited by 99Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal and reproductive studies

Does age play a role in clinical presentation of hypothyroidism?

Doucet, J., Trivalle, Ch., Chassagne, Ph., Perol, M‐B., Vuillermet, P., Manchon, N‐D., Menard, J‐F., Bercoff, E.·1994·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.1994.tb06592.x
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Abstract

OBJECTIVE: To determine if aging modifies the clinical presentation of hypothyroidism. DESIGN: Comparison of 24 clinical signs of hypothyroidism between elderly patients (> or = 70 years of age) and younger patients (< or = 55 years of age). SETTING: Prospective study of patients with chemically confirmed overt hypothyroidism. PATIENTS: Sixty seven elderly patients (79.3 +/- 6.7 years) and 54 younger patients (40.8 +/- 9 years) were included in the study. RESULTS: Neither mean duration of evolution nor mean thyroid-stimulating hormone (TSH) level were different between the 2 groups. Two signs were found in more than 50% of the elderly patients (fatigue and weakness). Four signs were significantly less frequent in elderly patients (chilliness, paresthesiae, weight gain, and cramps). Mean number of clinical signs in the elderly (6.6 +/- 4) was significantly smaller than in young patients (9.3 +/- 4.7) (P < 0.01). CONCLUSIONS: Our results suggest that the presentation of hypothyroidism is altered in the elderly in comparison with young patients in that there are (1) fewer signs or symptoms and (2) diminished frequency of some classical signs. Our results underline the importance of TSH measurement in the elderly.

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  • Patients with hypothyroidism may present with a variety of clinical symptoms and signs that are often related to metabolic slowing due to insufficient thyroid hormone production.

    “Patients with hypothyroidism may present with a variety of clinical symptoms and signs 7,40 that are often related to metabolic slowing due to insufficient thyroid hormone production (Table 2).”

    From Hypothyroidism: A Review (2025) · cites this paper as [40]

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Authors
Doucet, J., Trivalle, C., Chassagne, P., Perol, M., Vuillermet, P., Manchon, N., Menard, J., & Bercoff, E.
Affiliations
Centre Hospitalier Universitaire de Rouen (FR)
Corresponding author
Doucet, J.
ORCID
Doucet, J.
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
1994-09
Volume
42
Issue
9
Pages
984-986
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.1994.tb06592.x
OpenAlex
W1969874414
Cited by
99
References
10
Citations by year
2025: 4 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 6
FWCI
1.76
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7543 d)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
hypothyroidism, overt hypothyroidism, aging, elderly patients, clinical features, thyroid-stimulating hormone, fatigue, weight gain, cramps, age differences
MeSH terms
Adult, Age Factors, Aged, Aged, 80 and over, Female, Humans, Hypothyroidism, Male, Middle Aged, Prospective Studies, Thyrotropin

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