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Cited by 305

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Depression Without Sadness: Functional Outcomes of Nondysphoric Depression in Later Life

Gallo, Joseph J., Rabins, Peter V., Lyketsos, Constantine G., Tien, Allen Y., Anthony, James C.·1997·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.1997.tb03089.x
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Abstract

OBJECTIVES: We hypothesized that depressive symptoms not meeting full standard criteria for Major Depression would be associated with significant functional impairment among older adults over the course of a 13‐year follow‐up interval. Specifically, we developed criteria for a form of depression whose core symptoms did not include sadness or dysphoria. DESIGN: Population‐based 13‐year follow‐up survey. SETTING: Community‐dwelling adults living in East Baltimore in 1981. PARTICIPANTS: Subjects were the 1612 participants of the Baltimore sample of the Epidemiologic Catchment Area Program aged 50 years and older at the initial interview in 1981. MEASUREMENTS: The subjects were sorted into four categories based on their responses at baseline: (1) persons meeting standard criteria for Major Depression; (2) persons meeting alternative criteria for depression with dysphoria or (3) without dysphoria; and (4) a comparison category of persons not meeting any criteria for depression (“non‐cases”). The mortality and functional status of each group were compared after a 13‐year follow‐up interval. RESULTS: Compared with non‐cases, participants aged 50 years and older who reported depressive symptoms but who denied sadness or dysphoria (nondysphoric depression) were at increased risk for death (relative risk (RR) = 1.70; 95% confidence interval (CI) (1.09, 2.67)), impairment in activities of daily living (RR = 3.76; 95% CI (1.73, 8.14)), impairment in instrumental activities of daily living (RR = 5.07; 95% CI (2.24, 11.44)), psychologic distress (RR = 3.68; 95% CI (1.47, 9.21)), and cognitive impairment (RR = 3.00; 95% CI (1.31, 6.89)) after a 13‐year follow‐up interval. The findings were not wholly explained by potentially influential baseline characteristics such as age, education, selected comorbid medical conditions, and functional status. CONCLUSION: Among adults aged 50 years and older, nondysphoric depression may be as important as Major Depression in relation to the development of functional disability and other long‐term outcomes.

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Metadata

Authors
Gallo, J. J., Rabins, P. V., Lyketsos, C. G., Tien, A. Y., & Anthony, J. C.
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
1997-05
Volume
45
Issue
5
Pages
570-578
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.1997.tb03089.x
OpenAlex
W2031076686
Cited by
305
References
4
FWCI
17.56
Type
journal article
Language
en
Open access
closed

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