The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Aging and Cancer: The Double‐Edged Sword of Replicative Senescence
Abstract
Normal cells do not divide indefinitely. This trait, termed the finite replicative life span of cells, limits the capacity for cell division by a process termed cellular or replicative senescence. Replicative senescence is thought to be a tumor suppression mechanism and also a contributor to organismic aging. This article reviews what is known about the genetics and molecular biology of cell senescence. It discusses the evidence that replicative senescence suppresses tumorigenesis, at least in young organisms, and that it also contributes to the aging of mitotic tissues. Finally, it puts forth the somewhat unorthodox view that, in older organisms, senescent cells may actually contribute to carcinogenesis.
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Cites
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Cited by
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730
Self-citationp53 mutant mice that display early ageing-associated phenotypes
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Oxidative Stress in Aging Human Skin
Rinnerthaler, M., Bischof, J., Streubel, M., Trost, A., & Richter, K. (2015) · Biomolecules · doi:10.3390/biom5020545 · Cited by 1,053
DePinho, R. A. (2000) · Nature · doi:10.1038/35041694 · Cited by 951
Management of Cancer in the Older Person: A Practical Approach
Balducci, L., & Extermann, M. (2000) · The Oncologist · doi:10.1634/theoncologist.5-3-224 · Cited by 939
Metadata
- Authors
- Campisi, J.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 1997-04
- Volume
- 45
- Issue
- 4
- Pages
- 482-488
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2039101448
- Cited by
- 255
- References
- 50
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Campisi, J. (1997). Aging and Cancer: The Double‐Edged Sword of Replicative Senescence. Journal of the American Geriatrics Society. https://doi.org/10.1111/j.1532-5415.1997.tb05175.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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