The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Geriatric Syndromes: Clinical, Research, and Policy Implications of a Core Geriatric Concept: (See Editorial Comments by Dr. William Hazzard on pp 794–796)
Open accessAbstract
Geriatricians have embraced the term “geriatric syndrome,” using it extensively to highlight the unique features of common health conditions in older people. Geriatric syndromes, such as delirium, falls, incontinence, and frailty, are highly prevalent, multifactorial, and associated with substantial morbidity and poor outcomes. Nevertheless, this central geriatric concept has remained poorly defined. This article reviews criteria for defining geriatric syndromes and proposes a balanced approach of developing preliminary criteria based on peer‐reviewed evidence. Based on a review of the literature, four shared risk factors—older age, baseline cognitive impairment, baseline functional impairment, and impaired mobility—were identified across five common geriatric syndromes (pressure ulcers, incontinence, falls, functional decline, and delirium). Understanding basic mechanisms involved in geriatric syndromes will be critical to advancing research and developing targeted therapeutic options, although given the complexity of these multifactorial conditions, attempts to define relevant mechanisms will need to incorporate more‐complex models, including a focus on synergistic interactions between different risk factors. Finally, major barriers have been identified in translating research advances, such as preventive strategies of proven effectiveness for delirium and falls, into clinical practice and policy initiatives. National strategic initiatives are required to overcome barriers and to achieve clinical, research, and policy advances that will improve quality of life for older persons.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Guideline for the Prevention of Falls in Older Persons
Society, A. G., Society, G., Of, A. A., & On Falls Prevention, O. S. P. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49115.x · Cited by 2,242
Pathogenesis of osteoporosis: concepts, conflicts, and prospects
Raisz, L. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27071 · Cited by 1,779 · cited 1×
“In many ways, the use of genetically-modified animals (largely mice) has revolutionized the conduct of research designed to address the pathophysiology of complex conditions, such as osteoporosis(102; 103) and Alzheimer’s disease(104) by linking the presence or absence of a gene to a specific phenotype.”
BackgroundFerrucci, L., Guralnik, J. M., Studenski, S., Fried, L. P., Cutler, G. B., Walston, J. D., & The Interventions on Frailty Working Group (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52174.x · Cited by 1,027 · cited 1×
“Although there is not yet a consensus definition, frailty is defined here as impairment in mobility, balance, muscle strength, cognition, nutrition, endurance, and physical activity.(12) Frailty and the other geriatric syndromes may also feedback to result in the development of more risk factors and more geriatric syn…”
BackgroundSelf-citationInouye, S. K., Viscoli, C. M., Horwitz, R. I., Hurst, L. D., & Tinetti, M. E. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-6-199309150-00005 · Cited by 854
Self-citationReuben, D. B., Inouye, S. K., Bogardus, S. T., Baker, D. I., Leo‐Summers, L., & Cooney, L. M. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb03885.x · Cited by 802
Self-citationDelirium in an intensive care unit: a study of risk factors
Dubois, M.-J., Bergeron, N., Dumont, M., Dial, S., & Skrobik, Y. (2001) · Intensive Care Medicine · doi:10.1007/s001340101017 · Cited by 609
Cappola, A. R., Xue, Q.-L., Ferrucci, L., Guralnik, J. M., Volpato, S., & Fried, L. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021694 · Cited by 286
What is a disease?: Disease, disability and their definitions
Scully, J. L. (2004) · The EMBO Reports · doi:10.1038/sj.embor.7400195 · Cited by 195
Rubin, F. H., Williams, J. T., Lescisin, D. A., Mook, W. J., Hassan, S., & Inouye, S. K. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00744.x · Cited by 125
Self-citation
Research works printed but not linked: 125
- 10.1111/j.1532-5415.1991.tb01612.x · DOI
- 10.1046/j.1532-5415.2003.51174.x · DOI
- Stedman's Medical Dictionary.Philadelphia PA: Lippincott Williams & Wilkins 2006.
- Olde Rikkert MG, 2003, Geriatric syndromes, Medical misnomer or progress in geriatrics?, 61, 83
- 10.1001/jama.1995.03520410042024 · DOI · Paper page
- 10.1136/ard.16.1.118 · DOI
- 10.1002/art.1780170212 · DOI
- 10.1212/WNL.34.7.939 · DOI · Paper page
- 2000, Diagnostic and Statistical Manual of Mental Disorders
- 10.1016/S0965-206X(05)53004-3 · DOI
- 10.12968/jowc.2005.14.8.26820 · DOI
- 10.12968/jowc.2005.14.1.26724 · DOI
- 10.12968/jowc.2004.13.7.26638 · DOI
- 10.1111/j.1365-2648.2005.03441.x · DOI
- 10.1097/00129334-200504000-00011 · DOI
- 10.1097/00004650-200409000-00007 · DOI
- 10.1097/00129334-200311000-00012 · DOI
- Dunlop DD, 2002, Incidence of functional limitation in older adults, The impact of gender, race, and chronic conditions, 83, 964
- 10.1093/ageing/32.3.259 · DOI
- 10.1097/00003246-200109000-00004 · DOI
- 10.1001/jama.1995.03520350047027 · DOI · Paper page
- 10.1111/j.1532-5415.1992.tb01845.x · DOI · Paper page
- 10.2337/diacare.28.7.1730 · DOI
- 10.1002/nau.20089 · DOI
- Mecocci PSE, 2005, Cognitive impairment is the major risk factor for development of geriatric syndromes during hospitalization, Results from the GIFA study, 20, 262
- 10.1016/j.maturitas.2004.12.001 · DOI
- 10.1080/02813430500362803 · DOI
- Saxer S, 2005, Risk factors for urinary incontinence in nursing home residents, Swiss Med Wkly, 135, 495, 10.4414/smw.2005.10973 · DOI
- Wu J, 2005, Urinary retention in a general rehabilitation unit, Prevalence, clinical outcome, and the role of screening, 86, 1772
- 10.1093/ageing/32.2.194 · DOI
- 10.1093/gerona/57.10.M672 · DOI
- Bergland A, 2006, [Self‐reported walking, balance testing and risk of fall among the elderly], Tidsskr Nor Laegeforen, 126, 176
- 10.2519/jospt.2005.35.7.452 · DOI
- 10.1086/502500 · DOI
- 10.1159/000086372 · DOI
- Horikawa E, 2005, Risk of falls in Alzheimer's disease, A prospective study, 44, 717
- Kose N, 2005, The risk factors of fall and their correlation with balance, depression, cognitive impairment and mobility skills in elderly nursing home residents, Saudi Med J, 26, 978
- Kallin K, 2005, Factors associated with falls among older, cognitively impaired people in geriatric care settings, A population-based study, 13, 501
- 10.1080/09638280400018486 · DOI
- Shumway‐Cook A, 2005, Incidence of and risk factors for falls following hip fracture in community‐dwelling older adults, Phys Ther, 85, 648, 10.1093/ptj/85.7.648 · DOI
- 10.1046/j.1532-5415.2003.51404.x · DOI · Paper page
- 10.1016/j.archger.2005.06.001 · DOI
- Wu HY, 2006, Factors associated with functional decline of hospitalised older persons following discharge from an acute geriatric unit, Ann Acad Med Singapore, 35, 17, 10.47102/annals-acadmedsg.V35N1p17 · DOI
- Cornette P, 2006, Early evaluation of the risk of functional decline following hospitalization of older patients, Development of a predictive tool, 16, 203
- 10.1002/art.20968 · DOI
- 10.1093/ageing/afi137 · DOI
- Spiers NA, 2005, Diseases and impairments as risk factors for onset of disability in the older population in England and Wales, Findings from the Medical Research Council Cognitive Function and Ageing Study, 60, M248
- 10.1093/ageing/afh028 · DOI · Paper page
- 10.1001/archinte.163.11.1317 · DOI
- Wang LBG, 2002, Predictors of functional change, A longitudinal study of nondemented people aged 65 and older, 50, 1525
- 10.1093/ageing/28.2.153 · DOI
- Mor V, 1994, Functional transitions among the elderly, Patterns, predictors, and related hospital use, 84, 1274
- 10.1002/gps.1265 · DOI
- 10.1016/j.ijom.2004.03.005 · DOI
- 10.1016/j.amjsurg.2003.12.027 · DOI
- 10.1097/00019442-200405000-00010 · DOI
- 10.1017/S1041610204000365 · DOI
- 10.1007/s00268-004-7344-1 · DOI
- 10.1177/000348940411300111 · DOI
- Bohner H, 2003, Predicting delirium after vascular surgery, A model based on pre- and intraoperative data, 238, 149
- 10.1016/S0163-8343(03)00070-7 · DOI
- 10.1093/gerona/58.1.M76 · DOI · Paper page
- 10.1002/cncr.10889 · DOI
- 10.1016/S0163-8343(01)00168-2 · DOI
- 10.1186/cc1044 · DOI · Paper page
- Galanakis P, 2001, Acute confusional state in the elderly following hip surgery, Incidence, risk factors and complications, 16, 349
- 10.1016/S0163-8343(01)00117-7 · DOI · Paper page
- 10.1046/j.1532-5415.2001.49260.x · DOI
- 10.1159/000022130 · DOI
- Martin NJ, 2000, Development of delirium, A prospective cohort study in a community hospital, 12, 117
- 10.1016/S0002-9343(98)00292-7 · DOI · Paper page
- 10.1001/jama.1996.03530350034031 · DOI · Paper page
- 10.1111/j.1532-5415.1995.tb06385.x · DOI
- 10.1093/gerona/50A.2.M99 · DOI
- 10.1001/jama.1994.03510260066030 · DOI · Paper page
- Pompei P, 1994, Delirium in hospitalized older persons, Outcomes and predictors, 42, 809
- Jitapunkul S, 1992, Delirium in newly admitted elderly patients, A prospective study, 83, 307
- Williams‐Russo P, 1992, Post‐operative delirium, Predictors and prognosis in elderly orthopedic patients, 40, 759
- 10.1001/jama.1990.03440080075027 · DOI · Paper page
- 10.1111/j.1532-5415.1989.tb05874.x · DOI
- Rogers MP, 1989, Delirium after elective orthopedic surgery, Risk factors and natural history, 19, 109
- 10.1111/j.1532-5415.1988.tb04023.x · DOI · Paper page
- 10.1002/nur.4770080107 · DOI
- Seymour DG, 1980, Acute confusional states and dementia in the elderly, The role of dehydration/Volume depletion, physical illness and age, 9, 137
- 10.1172/JCI7304 · DOI
- 10.1172/JCI119470 · DOI · Paper page
- Hamosh A, 2005, Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders, Nucleic Acids Res, 33, D514, 10.1093/nar/gki033 · DOI · Paper page
- 10.1136/bmj.324.7342.883 · DOI
- 10.1016/j.amjmed.2003.09.031 · DOI · Paper page
- Scriver CR, 2000, The Metabolic and Molecular Bases of Inherited Disease
- Decker S, 2005, Preclinical modeling of combination treatments, Fantasy or requirement?, 1059, 61
- 10.1056/NEJM198812293192604 · DOI · Paper page
- 10.1056/NEJM199903043400901 · DOI · Paper page
- 10.1191/1740774505cn067oa · DOI
- Liebman MN., 2002, Opening Pandora's box, Clinical data and the study of complex diseases, 2002, PE20
- Lorenzo J., 2000, Interactions between immune and bone cells, New insights with many remaining questions, 106, 749
- 10.1016/S0168-9525(01)02449-0 · DOI
- 10.1038/nm1205-1261b · DOI
- Frazier SC., 2005, Health outcomes and polypharmacy in elderly individuals, An integrated literature review, 31, 4
- 10.1152/physiolgenomics.2001.5.4.205 · DOI
- 10.1007/s00125-005-1680-z · DOI · Paper page
- Kuchel GA, 2006, Aging patterns in mouse strains used in gene deletion studies, Implications for sarcopenic obesity, 54, S134
- Taylor JA, 2006, Detrusor underactivity, Clinical features and pathogenesis of an underdiagnosed geriatric condition, 54, 1920
- Elbadawi A, 1993, Structural basis of geriatric voiding dysfunction. II. Aging detrusor, Normal versus impaired contractility, 150, 1657
- 10.1152/ajprenal.00144.2006 · DOI
- Kuchel GA, 2006, Role of immune and endocrine factors in detrusor underactivity and urinary retention, J Am Geriatr Soc, 54, S13
- Meyer‐Siegler KL, 2006, Macrophage migration inhibitory factor is increased in the urine of patients with urinary tract infection, Macrophage migration inhibitory factor-protein complexes in human urine, 174, 1523
- Gitler MS, 2003, Preclinical models for defining efficacy of drug combinations, Mapping the road to the clinic, 2, 929
- Tinetti ME, 2006, Fall prevention, A case study of the challenges in adopting evidence-based geriatric care practices, 46, 717
- 10.1056/NEJMra052321 · DOI · Paper page
- Inouye SK, 2001, Nurses' recognition of delirium and its symptoms, Comparison of nurse and researcher ratings, 161, 2467
- Inouye SK, 2005, A chart‐based method for identification of delirium, Validation compared with interviewer ratings using the confusion assessment method, 53, 312
- 10.1111/j.1532-5415.2005.53005.x · DOI
- 10.1093/ageing/afi031 · DOI
- 10.1046/j.1532-5415.2001.49109.x · DOI · Paper page
- Marcantonio ER, 2001, Reducing delirium after hip fracture, A randomized trial, 49, 516
- Rizzo JA, 2001, Multicomponent targeted intervention to prevent delirium in hospitalized older patients, What is the economic value?, 39, 740
- 10.1111/j.1532-5415.2005.53156.x · DOI
- Bradley EH, 2004, Translating research into clinical practice, making change happen, 52, 1875
- Bradley EH, 2005, After adoption, Sustaining the innovation. A case study of disseminating the hospital elder life program, 53, 1455
- 10.1056/NEJM199409293311301 · DOI · Paper page
- 10.1007/s11606-006-0244-3 · DOI
- 10.1111/j.1532-5415.2005.53218.x · DOI
- 10.1111/j.1525-1497.2005.00298.x · DOI
- 10.1001/archinte.161.15.1897 · DOI · Paper page
Cited by
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
The World report on ageing and health: a policy framework for healthy ageing
Beard, J. R., Officer, A., de Carvalho, I. A., Sadana, R., Pot, A. M., Michel, J.-P., Lloyd-Sherlock, P., Epping-Jordan, J. E., Peeters, G. M. E. E. (., Mahanani, W. R., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00516-4 · Cited by 3,287
World guidelines for falls prevention and management for older adults: a global initiative
Montero-Odasso, M., van der Velde, N., Martin, F. C., Petrovic, M., Tan, M. P., Ryg, J., Aguilar-Navarro, S., Alexander, N. B., Becker, C., Blain, H., et al. (2022) · Age and Ageing · doi:10.1093/ageing/afac205 · Cited by 1,756
Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00260 · Cited by 1,377
Baijens, L. W., Clavé, P., Cras, P., Ekberg, O., Forster, A., Kolb, G., Leners, J. C., Masiero, S., Mateos del Nozal, J., Ortega, O., et al. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s107750 · Cited by 773
Metadata
- Authors
- Inouye, S. K., Studenski, S., Tinetti, M. E., & Kuchel, G. A.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2007-04-11
- Volume
- 55
- Issue
- 5
- Pages
- 780-791
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2120032954
- Cited by
- 1,874
- References
- 10
- FWCI
- 18.15
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Geriatric Syndromes: Clinical, Research, and Policy Implications of a Core Geriatric Concept: (See Editorial Comments by Dr. William Hazzard on pp 794–796). https://app.cochat.ai/papers/10.1111/j.1532-5415.2007.01156.x
- The paper
- Inouye, S. K., Studenski, S., Tinetti, M. E., & Kuchel, G. A. (2007). Geriatric Syndromes: Clinical, Research, and Policy Implications of a Core Geriatric Concept: (See Editorial Comments by Dr. William Hazzard on pp 794–796). Journal of the American Geriatrics Society. https://doi.org/10.1111/j.1532-5415.2007.01156.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.