Cited by 198Pharmaceutical Practices and Patient OutcomesPatient Safety and Medication ErrorsPharmacy and Medical Practices

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Discontinuing medications: a novel approach for revising the prescribing stage of the medication-use process

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Bain, Kevin T., Holmes, Holly M., Beers, Mark H., Maio, Vittorio, Handler, Steven M., Pauker, Stephen G.·2008·Journal of the American Geriatrics Society

DOI 10.1111/j.1532-5415.2008.01916.xPMC PMC3119470

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Abstract

Thousands of Americans are injured or die each year from adverse drug reactions, many of which are preventable. The burden of harm conveyed by the use of medications is a significant public health problem, and therefore, improving the medication-use process is a priority. Recent and ongoing efforts to improve the medication-use process have focused primarily on improving medication prescribing, and not much emphasis has been put on improving medication discontinuation. A formalized approach for rationally discontinuing medications is a necessary antecedent to improving medication safety and improving the nation's quality of care. This article proposes a conceptual framework for revising the prescribing stage of the medication-use process to include discontinuing medications. This framework has substantial practice and research implications, especially for the clinical care of older persons, who are particularly susceptible to the adverse effects of medications.

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Raman‐Wilms, L., Farrell, B. J., & Thompson, W. (2023) · Springer eBooks · doi:10.1007/978-3-030-50247-8_34-2
The pharmacological deprescription in elderly patients
Ali, C. R., Huang, D. Q., Tugwete, C., Canale, S. D., & Maio, V. (2023) · Italian Journal of Medicine · doi:10.4081/itjm.2023.1676
Self-citation
Additional file 2 of A scoping review of de-implementation frameworks and models
Walsh‐Bailey, C., Tsai, E., Tabak, R. G., Morshed, A. B., Norton, W. E., McKay, V. R., Brownson, R. C., & Gifford, S. E. (2021) · Figshare · doi:10.6084/m9.figshare.17079065
Additional file 3 of A scoping review of de-implementation frameworks and models
Walsh‐Bailey, C., Tsai, E., Tabak, R. G., Morshed, A. B., Norton, W. E., McKay, V. R., Brownson, R. C., & Gifford, S. E. (2021) · Figshare · doi:10.6084/m9.figshare.17079068
Additional file 1 of A scoping review of de-implementation frameworks and models
Walsh‐Bailey, C., Tsai, E., Tabak, R. G., Morshed, A. B., Norton, W. E., McKay, V. R., Brownson, R. C., & Gifford, S. E. (2021) · Figshare · doi:10.6084/m9.figshare.17079062
Additional file 1 of CancelRx case study: implications for clinic and community pharmacy work systems
Watterson, T. L., Stone, J. A., Kleinschmidt, P. C., & Chui, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26650140
Additional file 1 of Deprescribing research in nursing home residents using routinely collected healthcare data: a conceptual framework
Thorpe, C. T., Niznik, J., & Li, A. (2023) · Figshare · doi:10.6084/m9.figshare.23884400
Deprescribing in Older Populations: A Comprehensive Review of Evidence, Strategies, and Future Directions
Alam, S., Osama, M., Wei, C. R., Kumar, N., Khan, K., Khan, M. A., Ishaqui, A. A., & Siddiqui, N. H. (2026) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/0118756921397125251202105144
Identifying Medication Discontinuations Using Text Searching and Clinical Data
Goodrich, G. K., Bayliss, E. A., Lagrotteria, J., Barrow, J. C., Harding, B., Gleason, K. S., Kraus, C. R., Paolino, V., Norton, J. D., Sheehan, O. C., et al. (2026) · Medical Care · doi:10.1097/mlr.0000000000002369
Evidence on drug withdrawal reactions after medication discontinuation: An umbrella reviewPreprint
Khan, Z., Jungo, K. T., Beatty, J., Cullen, P., Spinewine, A., Reeve, E., & Moriarty, F. (2026) · Research Square · doi:10.21203/rs.3.rs-11293956/v1

Authors: Bain, K. T., Holmes, H. M., Beers, M. H., Maio, V., Handler, S. M., & Pauker, S. G.
Affiliations: University of the Sciences (US)
The University of Texas MD Anderson Cancer Center (US)
Thomas Jefferson University (US)
University of Pittsburgh (US)
Tufts University (US)
ORCID: Holmes, Holly M.
Maio, Vittorio
Handler, Steven M.
Venue: Journal of the American Geriatrics Society
Publisher: Wiley
Published: 2008-10
Volume: 56
Issue: 10
Pages: 1946-1952
ISSN: 0002-8614 (ISSN-L)
1532-5415
DOI: 10.1111/j.1532-5415.2008.01916.x
PMC: PMC3119470
OpenAlex: W2096341024
Cited by: 198
References: 38
Citations by year: 2026: 4 · 2025: 2 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 14 · 2020: 12 · 2019: 17 · 2018: 12 · 2017: 21 · 2016: 17 · 2015: 13 · 2014: 15 · 2013: 12 · 2012: 14
FWCI: 1.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of the American Geriatrics Society (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (KL2TR000146)
National Institute on Aging (L30 AG026830)
National Center for Research Resources (KL2RR024154)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Patient Safety and Medication Errors
Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
Keywords: drug discontinuation, medication process, drug prescribing, adverse drug reactions, drug safety, older adults, polypharmacy, conceptual framework, quality of care
MeSH terms: Aged, Aged, 80 and over, Drug Interactions, Drug Therapy, Drug Utilization, Humans, Drug Prescriptions, Substance Withdrawal Syndrome, Polypharmacy, Drug-Related Side Effects and Adverse Reactions

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Discontinuing medications: a novel approach for revising the prescribing stage of the medication-use process

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