CoChat
Sign Up
Cited by 428Frailty in Older AdultsNutrition and Health in AgingAging, Health, and Disability

The DOI matches its Crossref record; 46 of the 49 references it cites were found in a registry or an index.

Prognostic Significance of Potential Frailty Criteria

Open access
Rothman, Marc D., Leo‐Summers, Linda, Gill, Thomas M.·2008·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.2008.02008.xPMC PMC2782664
Open this paper in CoChat — free account

Abstract

OBJECTIVES: To determine the independent prognostic effect of seven potential frailty criteria, including five from the Fried phenotype, on several adverse outcomes. DESIGN: Prospective cohort study. SETTING: Greater New Haven, Connecticut. PARTICIPANTS: Seven hundred fifty‐four initially nondisabled, community‐living persons aged 70 and older. MEASUREMENTS: An assessment of seven potential frailty criteria (slow gait speed, low physical activity, weight loss, exhaustion, weakness, cognitive impairment, and depressive symptoms) was completed at baseline and every 18 months for 72 months. Participants were followed with monthly telephone interviews for up to 96 months to determine the occurrence of chronic disability, long‐term nursing home (NH) stays, injurious falls, and death. RESULTS: In analyses adjusted for age, sex, race, education, number of chronic conditions, and the presence of the other potential frailty criteria, three of the five Fried criteria (slow gait speed, low physical activity, and weight loss) were independently associated with chronic disability, long‐term NH stays, and death. Slow gait speed was the strongest predictor of chronic disability (hazard ratio (HR)=2.97, 95% confidence interval (CI)=2.32–3.80) and long‐term NH stay (HR=3.86, 95% CI=2.23–6.67) and was the only significant predictor of injurious falls (HR=2.19, 95% CI=1.33–3.60). Cognitive impairment was also associated with chronic disability (HR=1.82, 95% CI=1.40–2.38), long‐term NH stay (HR=2.64, 95% CI=1.75–3.99), and death (HR=1.54, 95% CI=1.13–2.10), and the magnitude of these associations was comparable with that of weight loss. CONCLUSION: The results of this study provide strong evidence to support the use of slow gait speed, low physical activity, weight loss, and cognitive impairment as key indicators of frailty while raising concerns about the value of self‐reported exhaustion and muscle weakness.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1532-5415.2008.02008.x

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 49 references

Research works printed but not linked: 2

  1. Walston J, 2006, Research agenda for frailty in older adults, Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults, 54, 991
  2. Kasper J., 2005, Who Stays and Who Goes Home: Using National Data on Nursing Home Discharges and Long‐Stay Residents to Draw Implications for Nursing Home Transition Programs

Cited by

Sorted by citations

See all 428

Related

Metadata

Authors
Rothman, M. D., Leo‐Summers, L., & Gill, T. M.
Affiliations
Yale University (US)
Corresponding author
Rothman, Marc D.
ORCID
Gill, Thomas M.
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2008-12
Volume
56
Issue
12
Pages
2211-2216
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.2008.02008.x
PMC
PMC2782664
OpenAlex
W2111326370
Cited by
428
References
49
Citations by year
2026: 2 · 2025: 10 · 2024: 8 · 2023: 20 · 2022: 11 · 2021: 24 · 2020: 24 · 2019: 30 · 2018: 21 · 2017: 33 · 2016: 44 · 2015: 42 · 2014: 33 · 2013: 34 · 2012: 29
FWCI
8.49
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R01AG022993, R37AG017560, K24AG021507, T32 AG1934, T32AG019134, P30AG021342)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
frailty, Fried criteria, slow walking, physical activity, weight loss, cognitive impairment, exhaustion, muscle weakness, chronic disability, falls, mortality, older adults, prognostic factors
MeSH terms
Aged, Female, Humans, Male, Prognosis, Prospective Studies, Geriatric Assessment, Frail Elderly

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review