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Cited by 252

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Effects of Transdermal Testosterone on Bone and Muscle in Older Men with Low Bioavailable Testosterone Levels, Low Bone Mass, and Physical Frailty

Open access
Kenny, Anne M., Kleppinger, Alison, Annis, Kristen, Rathier, Margaret, Browner, Bruce, Judge, James O., McGee, Daniel·2010·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.2010.02865.x
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Abstract

OBJECTIVES: To investigate the effects of testosterone supplementation on bone, body composition, muscle, physical function, and safety in older men. DESIGN: Double‐blind, randomized, placebo‐controlled trial. SETTING: A major medical institution. PARTICIPANTS: One hundred thirty‐one men (mean age 77.1 ± 7.6) with low testosterone, history of fracture, or bone mineral density (BMD) T ‐score less than −2.0 and frailty. INTERVENTION: Participants received 5 mg/d of testosterone or placebo for 12 to 24 months; all received calcium (1500 mg/d diet and supplement) and cholecalciferol (1,000 IU/d). MEASUREMENTS: BMD of hip, lumbar spine, and mid‐radius; body composition; sex hormones, calcium‐regulating hormones; bone turnover markers; strength; physical performance; and safety parameters. RESULTS: Ninety‐nine men (75.6%) completed 12 months, and 62 (47.3%) completed end therapy (mean 23 months; range 16–24 months for 62 who completed therapy). Study adherence was 54%, with 40% of subjects maintaining 70% or greater adherence. Testosterone and bioavailable testosterone levels at 12 months were 583 ng/dL and 157 ng/dL, respectively, in the treatment group. BMD on testosterone increased 1.4% at the femoral neck and 3.2% at the lumbar spine ( P =.005) and decreased 1.3% at the mid‐radius ( P <.001). There was an increase in lean mass and a decrease in fat mass in the testosterone group but no differences in strength or physical performance. There were no differences in safety parameters. CONCLUSION: Older, frail men receiving testosterone replacement increased testosterone levels and had favorable changes in body composition, modest changes in axial BMD, and no substantial changes in physical function.

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Citations

Cites

Show all 12 references

Research works printed but not linked: 19

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Metadata

Authors
Kenny, A. M., Kleppinger, A., Annis, K., Rathier, M., Browner, B., Judge, J. O., & McGee, D.
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2010-06
Volume
58
Issue
6
Pages
1134-1143
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.2010.02865.x
OpenAlex
W1629389488
Cited by
252
References
12
FWCI
14.31
Type
journal article
Language
en
Open access
green
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Effects of Transdermal Testosterone on Bone and Muscle in Older Men with Low Bioavailable Testosterone Levels, Low Bone Mass, and Physical Frailty. https://app.cochat.ai/papers/10.1111/j.1532-5415.2010.02865.x
The paper
Kenny, A. M., Kleppinger, A., Annis, K., Rathier, M., Browner, B., Judge, J. O., & McGee, D. (2010). Effects of Transdermal Testosterone on Bone and Muscle in Older Men with Low Bioavailable Testosterone Levels, Low Bone Mass, and Physical Frailty. Journal of the American Geriatrics Society. https://doi.org/10.1111/j.1532-5415.2010.02865.x

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.