Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 252

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Effects of Transdermal Testosterone on Bone and Muscle in Older Men with Low Bioavailable Testosterone Levels, Low Bone Mass, and Physical Frailty

Open access
Kenny, Anne M., Kleppinger, Alison, Annis, Kristen, Rathier, Margaret, Browner, Bruce, Judge, James O., McGee, Daniel·2010·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.2010.02865.x
Open this paper in CoChat — free account

Abstract

OBJECTIVES: To investigate the effects of testosterone supplementation on bone, body composition, muscle, physical function, and safety in older men. DESIGN: Double‐blind, randomized, placebo‐controlled trial. SETTING: A major medical institution. PARTICIPANTS: One hundred thirty‐one men (mean age 77.1 ± 7.6) with low testosterone, history of fracture, or bone mineral density (BMD) T ‐score less than −2.0 and frailty. INTERVENTION: Participants received 5 mg/d of testosterone or placebo for 12 to 24 months; all received calcium (1500 mg/d diet and supplement) and cholecalciferol (1,000 IU/d). MEASUREMENTS: BMD of hip, lumbar spine, and mid‐radius; body composition; sex hormones, calcium‐regulating hormones; bone turnover markers; strength; physical performance; and safety parameters. RESULTS: Ninety‐nine men (75.6%) completed 12 months, and 62 (47.3%) completed end therapy (mean 23 months; range 16–24 months for 62 who completed therapy). Study adherence was 54%, with 40% of subjects maintaining 70% or greater adherence. Testosterone and bioavailable testosterone levels at 12 months were 583 ng/dL and 157 ng/dL, respectively, in the treatment group. BMD on testosterone increased 1.4% at the femoral neck and 3.2% at the lumbar spine ( P =.005) and decreased 1.3% at the mid‐radius ( P <.001). There was an increase in lean mass and a decrease in fat mass in the testosterone group but no differences in strength or physical performance. There were no differences in safety parameters. CONCLUSION: Older, frail men receiving testosterone replacement increased testosterone levels and had favorable changes in body composition, modest changes in axial BMD, and no substantial changes in physical function.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1532-5415.2010.02865.x

Cites

12 of 12 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 19

  1. Gray A, 1991, An examination of research design effects on the association of testosterone and aging, Results of a meta-analysis, 44, 671
  2. Morley JE, 1993, Effects of testosterone replacement therapy in old hypogonadal males, A preliminary study, 41, 149
  3. 10.1111/j.1532-5415.2007.01121.x · DOI
  4. 10.1093/gerona/56.5.M266 · DOI · Paper page
  5. 10.1210/jc.2003-031110 · DOI · Paper page
  6. Institute of Medicine., 2003, Testosterone and Aging: Clinical Research Directions. Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy
  7. Washburn RA, 1993, The Physical Activity Scale for the Elderly (PASE), Development and evaluation, 46, 153
  8. Wang ZM, 1996, Skeletal muscle mass, Evaluation of neutron activation and dual-energy X-ray absorptiometry methods, 80, 824
  9. 10.1111/j.1532-5415.1996.tb01404.x · DOI · Paper page
  10. 10.1093/geronj/44.5.M141 · DOI · Paper page
  11. 10.1111/j.1532-5415.1997.tb03088.x · DOI
  12. Isidori AM, 2005, Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle‐aged men, A meta-analysis, 63, 280
  13. Bhasin S, 2006, Drug insight, Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging, 2, 146
  14. Calof OM, 2005, Adverse events associated with testosterone replacement in middle‐aged and older men, A systematic review of randomized, placebo-controlled trials, 60, 1451
  15. Blackman MR, 2002, Growth hormone and sex steroid administration in healthy aged women and men, A randomized controlled trial, 288, 2282
  16. 10.1152/ajpendo.1995.269.5.E820 · DOI · Paper page
  17. 10.1093/ptj/80.9.896 · DOI · Paper page
  18. Araujo AB, 2004, Prevalence and incidence of androgen deficiency in middle‐aged and older men, Estimates from the Massacheuetts Male Study, 89, 5920
  19. 10.1210/jc.2004-0804 · DOI · Paper page

Cited by

See all 252

Metadata

Authors
Kenny, A. M., Kleppinger, A., Annis, K., Rathier, M., Browner, B., Judge, J. O., & McGee, D.
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2010-06
Volume
58
Issue
6
Pages
1134-1143
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.2010.02865.x
OpenAlex
W1629389488
Cited by
252
References
12
FWCI
14.31
Type
journal article
Language
en
Open access
green
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.