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Cited by 125Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsNutrition and Health in Aging

The DOI matches its Crossref record; 49 of the 53 references it cites were found in a registry or an index.

Dehydroepiandrosterone Combined with Exercise Improves Muscle Strength and Physical Function in Frail Older Women

Kenny, Anne M., Boxer, Rebecca S., Kleppinger, Alison, Brindisi, Jennifer, Feinn, Richard, Burleson, Joseph A.·2010·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.2010.03019.x
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Abstract

OBJECTIVES: To investigate the effects of dehydroepiandrosterone (DHEA) combined with exercise on bone mass, strength, and physical function in older, frail women. DESIGN: Double‐blind, randomized, placebo‐controlled trial. SETTING: A major medical institution. PARTICIPANTS: Ninety‐nine women (mean age 76.6 ± 6.0) with low sulfated DHEA (DHEAS) levels, low bone mass, and frailty. INTERVENTION: Participants received 50 mg/d DHEA or placebo for 6 months; all received calcium and cholecalciferol. Women participated in 90‐minute twice‐weekly exercise regimens. MEASUREMENTS: Hormone levels, bone mineral density (BMD), bone turnover markers, body composition, upper and lower extremity strength, physical performance. RESULTS: Eighty‐seven women (88%) completed 6 months. There were no significant changes in BMD or bone turnover markers. DHEA supplementation resulted in gains in lower extremity strength (from 459 ± 121 N to 484 ± 147 N; P =.01). There was also improvement in Short Physical Performance Battery score, a composite score that focuses on lower extremity function, in those taking DHEA (from 10.1 ± 1.8 to 10.7 ± 1.9; P =.02). There were significant changes in all hormone levels, including DHEAS, estradiol, estrone, and testosterone, and a decline in sex hormone‐binding globulin levels in those taking DHEA. CONCLUSION: DHEA supplementation improved lower extremity strength and function in older, frail women involved in a gentle exercise program of chair aerobics or yoga. No changes were found in BMD either due to small sample size, short duration of study or no effect. The physical function findings are promising and require further evaluation as frail women are at high risk for falls and fracture.

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Crossref · 10.1111/j.1532-5415.2010.03019.x

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  1. 10.1210/jc.85.12.4650 · DOI · Paper page

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Metadata

Authors
Kenny, A. M., Boxer, R. S., Kleppinger, A., Brindisi, J., Feinn, R., & Burleson, J. A.
Affiliations
Case Western Reserve University (US)
ORCID
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2010-09
Volume
58
Issue
9
Pages
1707-1714
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.2010.03019.x
OpenAlex
W2160677204
Cited by
125
References
53
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 5 · 2014: 15 · 2013: 13 · 2012: 11
FWCI
9.44
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1 d)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Center for Research Resources (M01RR006192)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords
dehydroepiandrosterone, DHEA supplementation, frailty, older women, muscle strength, physical function, physical activity, bone mineral density, bone turnover markers, sex hormones, sex hormone-binding globulin, dehydroepiandrosterone sulfate, yoga, falls and fractures
MeSH terms
Adjuvants, Immunologic, Administration, Oral, Aged, Dehydroepiandrosterone, Dose-Response Relationship, Drug, Double-Blind Method, Exercise Therapy, Female, Follow-Up Studies, Humans, Leg, Motor Activity, Osteoporosis, Prognosis, Sex Hormone-Binding Globulin, Bone Density, Frail Elderly, Muscle Strength

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