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Dehydroepiandrosterone Combined with Exercise Improves Muscle Strength and Physical Function in Frail Older Women
Abstract
OBJECTIVES: To investigate the effects of dehydroepiandrosterone (DHEA) combined with exercise on bone mass, strength, and physical function in older, frail women. DESIGN: Double‐blind, randomized, placebo‐controlled trial. SETTING: A major medical institution. PARTICIPANTS: Ninety‐nine women (mean age 76.6 ± 6.0) with low sulfated DHEA (DHEAS) levels, low bone mass, and frailty. INTERVENTION: Participants received 50 mg/d DHEA or placebo for 6 months; all received calcium and cholecalciferol. Women participated in 90‐minute twice‐weekly exercise regimens. MEASUREMENTS: Hormone levels, bone mineral density (BMD), bone turnover markers, body composition, upper and lower extremity strength, physical performance. RESULTS: Eighty‐seven women (88%) completed 6 months. There were no significant changes in BMD or bone turnover markers. DHEA supplementation resulted in gains in lower extremity strength (from 459 ± 121 N to 484 ± 147 N; P =.01). There was also improvement in Short Physical Performance Battery score, a composite score that focuses on lower extremity function, in those taking DHEA (from 10.1 ± 1.8 to 10.7 ± 1.9; P =.02). There were significant changes in all hormone levels, including DHEAS, estradiol, estrone, and testosterone, and a decline in sex hormone‐binding globulin levels in those taking DHEA. CONCLUSION: DHEA supplementation improved lower extremity strength and function in older, frail women involved in a gentle exercise program of chair aerobics or yoga. No changes were found in BMD either due to small sample size, short duration of study or no effect. The physical function findings are promising and require further evaluation as frail women are at high risk for falls and fracture.
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“Notably, most studies that showed improvements utilized multicomponent exercise programs [84,109,[146], [147], [148]], in contrast to those that only employed resistance exercises [149] or combined aerobic training with yoga [150].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [150]
Citations
Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons
Podsiadlo, D., & Richardson, S. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb01616.x · Cited by 14,418
Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792
High-Intensity Strength Training in Nonagenarians: Effects on Skeletal Muscle
Fiatarone, M. A. (1990) · JAMA · doi:10.1001/jama.1990.03440220053029 · Cited by 1,593
ORENTREICH, N., BRIND, J. L., RIZER, R. L., & VOGELMAN, J. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-551 · Cited by 1,349
Clinical and laboratory measures of postural balance in an elderly population.
Berg, K., Maki, B. E., Williams, J. I., Holliday, P. J., & Wood-Dauphinée, S. (1992) · PubMed · Cited by 1,251
Effects of High-Intensity Strength Training on Multiple Risk Factors for Osteoporotic Fractures
Nelson, M. E. (1994) · JAMA · doi:10.1001/jama.1994.03520240037038 · Cited by 1,024
The Physical Activity Scale for the Elderly (PASE)
Washburn, R. A., McAuley, E., Katula, J. A., Mihalko, S. L., & Boileau, R. A. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00049-9 · Cited by 999
Weight-Bearing Exercise Training and Lumbar Bone Mineral Content in Postmenopausal Women
Dalsky, G. P., STOCKE, K. S., EHSANI, A. A., SLATOPOLSKY, E., LEE, W. C., & BIRGE, S. J. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-6-824 · Cited by 740
The LIFE Study Investigators* [*See Appendix for List of LIFE Study Investigators] (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.11.1157 · Cited by 668
Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency
Arlt, W., Callies, F., van Vlijmen, J. C., Koehler, I., Reincke, M., Bidlingmaier, M., Huebler, D., Oettel, M., Ernst, M., Schulte, H. M., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411401 · Cited by 644
Baulieu, E.-E., Thomas, G., Legrain, S., Lahlou, N., Roger, M., Debuire, B., Faucounau, V., Girard, L., Hervy, M.-P., Latour, F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4279 · Cited by 577
DHEA in elderly women and DHEA or testosterone in elderly men.
Nair, K. S., Rizza, R. A., O'Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054629 · Cited by 566
Physical Performance Measures in Aging Research
Guralnik, J. M., Branch, L. G., Cummings, S. R., & Curb, J. D. (1989) · Journal of Gerontology · doi:10.1093/geronj/44.5.m141 · Cited by 564
Binder, E. F., Schechtman, K. B., Ehsani, A. A., Steger‐May, K., Brown, M., Sinacore, D. R., Yarasheski, K. E., & Holloszy, J. O. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50601.x · Cited by 549
Harlow, L. L., Newcomb, M. D., & Bentler, P. M. (1986) · Journal of Clinical Psychology · doi:10.1002/1097-4679(198601)42:1 · Cited by 544
Morales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00507.x · Cited by 418
Hunt, P. J., Gurnell, E. M., Huppert, F. A., Richards, C., Prevost, A. T., Wass, J. A. H., Herbert, J., & Chatterjee, V. K. K. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7022 · Cited by 386 · cited 1×
“Preliminary studies found beneficial effects of DHEA on sense of well-being and energy in young individuals with primary and secondary adrenal insufficiency.(6,7) The studies evaluating the effects of DHEA supplementation in older adults are few, and the effects on bone and muscle function have been variable.”
BackgroundEffects of Extended Outpatient Rehabilitation After Hip Fracture
Binder, E. F., Brown, M., Sinacore, D. R., Steger-May, K., Yarasheski, K. E., & Schechtman, K. B. (2004) · JAMA · doi:10.1001/jama.292.7.837 · Cited by 380
Meta-analysis of walking for preservation of bone mineral density in postmenopausal women
James, M. M., & Carroll, S. (2008) · Bone · doi:10.1016/j.bone.2008.05.012 · Cited by 294
Berr, C., Lafont, S., Debuire, B., Dartigues, J., & Baulieu, É.-É. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13410 · Cited by 292
Leng, S. X., Cappola, A. R., Andersen, R. E., Blackman, M. R., Koenig, K., Blair, M., & Walston, J. D. (2004) · Aging Clinical and Experimental Research · doi:10.1007/bf03324545 · Cited by 270
Skeletal muscle mass: evaluation of neutron activation and dual-energy X-ray absorptiometry methods
Wang, Z. M., Visser, M., Ma, R., Baumgartner, R., Kotler, D. P., Gallagher, D., & Heymsfield, S. B. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.3.824 · Cited by 255
Villareal, D. T., & Holloszy, J. O. (2004) · JAMA · doi:10.1001/jama.292.18.2243 · Cited by 241
High-intensity resistance training and postmenopausal bone loss: a meta-analysis
James, M. M., & Carroll, S. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0083-4 · Cited by 210
(1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-89-6-1016_3 · Cited by 210
Prestwood, K. M., Kenny, A. M., Kleppinger, A., & Kulldorff, M. (2003) · JAMA · doi:10.1001/jama.290.8.1042 · Cited by 200
Self-citationEffects of DHEA replacement on bone mineral density and body composition in elderly women and men
Villareal, D. T., Holloszy, J. O., & Kohrt, W. M. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01131.x · Cited by 169
Percheron, G., Hogrel, J., Denot-Ledunois, S., Fayet, G., Forette, F., Baulieu, É.-É., Fardeau, M., & Marini, J. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.6.720 · Cited by 140
Arlt, W., Callies, F., Koehler, I., van Vlijmen, J. C., Faßnacht, M., Strasburger, C. J., Seibel, M. J., Huebler, D., Ernst, M. E., Oettel, M., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7974 · Cited by 139
DHEA enhances effects of weight training on muscle mass and strength in elderly women and men
Villareal, D. T., & Holloszy, J. O. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00100.2006 · Cited by 116
Wu, J., Oka, J., Higuchi, M., Tabata, I., Toda, T., Fujioka, M., Fuku, N., Teramoto, T., Okuhira, T., Ueno, T., et al. (2006) · Metabolism · doi:10.1016/j.metabol.2005.10.002 · Cited by 113
Jankowski, C. M., Gozansky, W. S., Schwartz, R. S., Dahl, D. J., Kittelson, J. M., Scott, S., Pelt, R. E. V., & Kohrt, W. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2484 · Cited by 109
von Mühlen, D. G., Laughlin, G. A., Kritz‐Silverstein, D. C., Bergstrom, J., & Bettencourt, R. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0520-z · Cited by 101
O’Donnell, A. B., Travison, T. G., Harris, S. S., Tenover, J. L., & McKinlay, J. B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1227 · Cited by 94 · cited 1×
“A cross-sectional analysis of physical performance and hormone status found an association between physical performance (physical performance test and chair rise time) and DHEA levels in men.(30) A few other studies have evaluated physical performance but have found no change in physical performance in men(15) or wome…”
The association between dehydroepiandosterone and frailty in older men and women
Voznesensky, M., Walsh, S., Dauser, D., Brindisi, J., & Kenny, A. M. (2009) · Age and Ageing · doi:10.1093/ageing/afp015 · Cited by 88
Self-citationIgwebuike, A., Irving, B. A., Bigelow, M. L., Short, K. R., McConnell, J. P., & Nair, K. S. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1027 · Cited by 71
DHEA in Elderly Women and DHEA or Testosterone in Elderly Men
Nair, K. S., Rizza, R. A., Brien, P. O., Dhatariya, K., Short, K. R., Nehra, A. X., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., et al. (2007) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000253416.67338.dc · Cited by 69
Effects of Age on Serum Dehydroepiandrosterone Sulfate, IGF-I, and IL-6 Levels in Women
Haden, S. T., Glowacki, J., Hurwitz, S., Rosen, C. J., & LeBoff, M. S. (2000) · Calcified Tissue International · doi:10.1007/s002230010084 · Cited by 68
Effects of Dehydroepiandrosterone and Atamestane Supplementation on Frailty in Elderly Men
Muller, M., van den Beld, A. W., van der Schouw, Y. T., Grobbee, D. E., & Lamberts, S. W. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2433 · Cited by 62
Jankowski, C. M., Gozansky, W. S., Kittelson, J. M., Pelt, R. E. V., Schwartz, R. S., & Kohrt, W. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2614 · Cited by 55
Takayanagi, R., Goto, K., Suzuki, S., Tanaka, S., Shimoda, S., & Nawata, H. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00394-3 · Cited by 49
Home-based resistance training improves femoral bone mineral density in women on hormone therapy
Judge, J. O., Kleppinger, A., Kenny, R. A., Smith, J., Biskup, B., & Marcella, G. (2005) · Osteoporosis International · doi:10.1007/s00198-004-1816-x · Cited by 46
Self-citationSupplementation with DHEA: Effect on Muscle Size, Strength, Quality of Life, and Lipids
Dayal, M. B., Sammel, M. D., Zhao, J., Hummel, A. C., Vandenbourne, K., & Barnhart, K. T. (2005) · Journal of Women s Health · doi:10.1089/jwh.2005.14.391 · Cited by 41
Tummala, S., & Svec, F. (1999) · Clinical Biochemistry · doi:10.1016/s0009-9120(99)00021-1 · Cited by 33
The Dehydroepiandrosterone And WellNess (DAWN) study: Research design and methods
von Mühlen, D. G., Laughlin, G. A., Kritz‐Silverstein, D. C., & Barrett-Connor, E. L. (2006) · Contemporary Clinical Trials · doi:10.1016/j.cct.2006.04.009 · Cited by 32
Effects of Dehydroepiandrosterone on Bone Mineral Density
Villareal, D. T. (2002) · Treatments in Endocrinology · doi:10.2165/00024677-200201060-00001 · Cited by 16
Ultralow-dose micronized 17beta-estradiol and bone density and bone metabolism in older women
(2003) · Obstetrics and Gynecology · doi:10.1097/00006250-200312000-00037 · Cited by 4
Berr, C., Lafont, S., Debuire, B., Dartigues, J., & Baulieu, É.-É. (1997) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199704000-00019 · Cited by 2
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Metadata
- Authors
- Kenny, A. M., Boxer, R. S., Kleppinger, A., Brindisi, J., Feinn, R., & Burleson, J. A.
- Affiliations
- Case Western Reserve University (US)
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2010-09
- Volume
- 58
- Issue
- 9
- Pages
- 1707-1714
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2160677204
- Cited by
- 125
- References
- 53
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 5 · 2014: 15 · 2013: 13 · 2012: 11
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (M01RR006192)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- dehydroepiandrosterone, DHEA supplementation, frailty, older women, muscle strength, physical function, physical activity, bone mineral density, bone turnover markers, sex hormones, sex hormone-binding globulin, dehydroepiandrosterone sulfate, yoga, falls and fractures
- MeSH terms
- Adjuvants, Immunologic, Administration, Oral, Aged, Dehydroepiandrosterone, Dose-Response Relationship, Drug, Double-Blind Method, Exercise Therapy, Female, Follow-Up Studies, Humans, Leg, Motor Activity, Osteoporosis, Prognosis, Sex Hormone-Binding Globulin, Bone Density, Frail Elderly, Muscle Strength
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