Cited by 363Nutrition and Health in AgingFrailty in Older AdultsBody Composition Measurement Techniques

An evidence-based comparison of operational criteria for the presence of sarcopenia

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Dam, T.-T., Peters, K. W., Fragala, M., Cawthon, P. M., Harris, T. B., McLean, R., Shardell, M., Alley, D. E. +7 more·2014·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Abstract

BACKGROUND: Several consensus groups have previously published operational criteria for sarcopenia, incorporating lean mass with strength and/or physical performance. The purpose of this manuscript is to describe the prevalence, agreement, and discrepancies between the Foundation for the National Institutes of Health (FNIH) criteria with other operational definitions for sarcopenia. METHODS: The FNIH Sarcopenia Project used data from nine studies including: Age, Gene and Environment Susceptibility-Reykjavik Study; Boston Puerto Rican Health Study; a series of six clinical trials from the University of Connecticut; Framingham Heart Study; Health, Aging, and Body Composition Study; Invecchiare in Chianti; Osteoporotic Fractures in Men Study; Rancho Bernardo Study; and Study of Osteoporotic Fractures. Participants included in these analyses were aged 65 and older and had measures of body mass index, appendicular lean mass, grip strength, and gait speed. RESULTS: The prevalence of sarcopenia and agreement proportions was higher in women than men. The lowest prevalence was observed with the FNIH criteria (1.3% men and 2.3% women) compared with the International Working Group and the European Working Group for Sarcopenia in Older Persons (5.1% and 5.3% in men and 11.8% and 13.3% in women, respectively). The positive percent agreements between the FNIH criteria and other criteria were low, ranging from 7% to 32% in men and 5% to 19% in women. However, the negative percent agreement were high (all >95%). CONCLUSIONS: The FNIH criteria result in a more conservative operational definition of sarcopenia, and the prevalence was lower compared with other proposed criteria. Agreement for diagnosing sarcopenia was low, but agreement for ruling out sarcopenia was very high. Consensus on the operational criteria for the diagnosis of sarcopenia is much needed to characterize populations for study and to identify adults for treatment.

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  • Larger muscle areas are associated with higher muscle strength, but LBM is not the only determinant.

    “Despite the fact that larger muscle areas are associated with higher muscle strength, LBM is not the only determinant [42,43].”

    From Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis (2018) · cites this paper as [43]

    The Results and Discussion report that adults with higher appendicular lean mass could nevertheless have weaker grip strength, supporting the point that lean mass is not the only determinant of strength. The paper does not establish the claimed association between larger muscle areas and higher strength; it measures lean mass rather than muscle area. (LLM, conf=0.84)

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  1. [30]Armitage P Colton T Encyclopedia of Biostatistics, 6 Volume Set. Hoboken, NJ: John Wiley & Sons; 1998

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Authors
Dam, T.-T., Peters, K. W., Fragala, M., Cawthon, P. M., Harris, T. B., McLean, R., Shardell, M., Alley, D. E., Kenny, A., Ferrucci, L., Guralnik, J., Kiel, D. P., Kritchevsky, S., Vassileva, M. T., & Studenski, S.
Affiliations
  • Columbia University Irving Medical Center (US)
  • California Pacific Medical Center (US)
  • University of Central Florida (US)
  • National Institutes of Health (US)
  • Beth Israel Deaconess Medical Center (US)
  • University of Maryland, Baltimore (US)
  • Wake Forest University Health Sciences (US)
  • Foundation for the National Institutes of Health (US)
  • University of Pittsburgh (US)
Corresponding author
Dam, T.-T.
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Published
2014-04-14
Volume
69
Issue
5
Pages
584-590
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
OpenAlex
W2162998896
Cited by
363
References
39
Citations by year
2026: 2 · 2025: 7 · 2024: 21 · 2023: 22 · 2022: 25 · 2021: 27 · 2020: 38 · 2019: 35 · 2018: 44 · 2017: 41 · 2016: 37 · 2015: 43 · 2014: 20
FWCI
31.25
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • The Journals of Gerontology Series A (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • Journal of International Crisis and Risk Communication Research (submittedVersion)
Funders
  • Foundation for the National Institutes of Health (P30 AG024827)
  • Amgen
  • Eli Lilly and Company
  • National Institutes of Health (AG024827)
  • National Institute on Aging (AG 024827, K23AG040168, U13AG04158, P30AG024827)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
Keywords
sarcopenia, prevalence, diagnostic agreement, older adults, appendicular lean mass, grip strength, walking speed, sex differences
MeSH terms
Age Factors, Aged, Female, Gait, Humans, Male, National Institutes of Health (U.S.), Sex Factors, Thinness, United States, Body Mass Index, Prevalence, Hand Strength, Sarcopenia

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