Functional characteristics of photochemically treated platelets
Abstract
BACKGROUND: A photochemical treatment (PCT) process using the psoralen compound amotosalen HCL (S59) and long wavelength UVA light was developed for inactivation of infectious pathogens and WBCs. In this study the effect of PCT on functional characteristics of the platelets was evaluated in vitro. STUDY DESIGN AND METHODS: Platelet concentrates were treated photochemically using the experimental clinical processing system T‐bag S59 Reduction Device (SRD) (n = 4) or the commercially available integral processing system Wafer SRD (n = 4) and compared with control platelet concentrates in plasma/PAS III alone (n = 4). The evaluation included variables with respect to the overall quality of the product (e.g., HSR, pH), the function (aggregation and activation tests), apoptosis (annexin V and caspase 3), and lysis. RESULTS: No differences were found in the product quality variables, in P‐selectin expression, and the apoptosis variables. PCT using the T‐bag SRD led to a significant decrease in aggregation capacity with collagen and thrombin and a significant increase in plasma LDH, whereas no differences for the Wafer SRD were found. CONCLUSION: PCT using the experimental T‐bag SRD led to a significant decrease in platelet function. However, the commercially available Wafer SRD had only minor in vitro effects on the quality of the platelets.
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Furan- and pyrone-side monoadducts of both 8-MOP and S59 are formed upon UVA irradiation in a much lower yield (close to 1%) than ICLs.
“It was found that furan-and pyrone-side monoadducts of both 8-MOP and S59, a recently developed psoralen derivative for pathogen inactivation in blood products (171,172), are formed upon UVA irradiation in a much lower yield (close to 1%) than ICLs.”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [171]
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Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup>
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- Authors
- Jansen, G. A. J., Van Vliet, H. H. D. M., Vermeij, H., Beckers, E. A. M., Leebeek, F. W. G., Sonneveld, P., & Van Rhenen, D. J.
- Affiliations
- Erasmus MC (NL)
- Venue
- Transfusion
- Publisher
- Wiley
- Published
- 2004-03
- Volume
- 44
- Issue
- 3
- Pages
- 313-319
- ISSN
- 0041-1132 (ISSN-L)
- 1537-2995
- OpenAlex
- W2037314450
- Cited by
- 41
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transfusion (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- photochemical treatment, platelets, amotosalen, platelet concentrates, platelet aggregation, platelet activation, apoptosis, platelet lysis, platelet function, P-selectin
- MeSH terms
- Bacterial Infections, Blood Platelets, Blood Preservation, Humans, Photochemistry, Platelet Aggregation, Furocoumarins, Ultraviolet Rays, Apoptosis
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