The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.
Influence of different IgG anticardiolipin antibody cut‐off values on antiphospholipid syndrome classification
Open accessAbstract
Background While medium to high titers of anticardiolipin (aCL) antibodies, defined as >40 GPL units or >99th percentile, is a laboratory criteria for the 'definite' diagnosis of antiphospholipid syndrome (APS), agreement between the two cut-offs has not been validated.Objective To validate the current aCL laboratory criterion by verifying the effect of the two cut-offs on APS classification.Patients/methods Ninety aCL positive APS patients were selected on the basis of their GPL values above the 99th percentile (17.4 GPL), which was calculated by testing 100 age- and sex-matched healthy subjects.Results A significant difference in the IgG positivity (P < 0.0001) was found between the APS laboratory profiles as 20 out of the 24 (83.3%) patients with single positivity (aCL alone), six out of the 23 (26.1%) with double positivity (aCL plus lupus anticoagulant or anti-beta(2)glycoprotein I), and none out of the 43 with triple positivity (aCL plus lupus anticoagulant and anti-beta(2)glycoprotein I) had titers between the 99th percentile and 40 GPL units. Moreover, the rate of aCL values between the 99th percentile and 40 GPL units was significantly higher (P < 0.0001) in patients with pregnancy morbidity (73.7%) as compared to those with vascular thrombosis (16.9%) and those with both conditions (16.7%).Conclusion The 99th percentile cut-off level seems more sensitive than the >40 GPL value for APS classification, as it includes subjects with aCL positivity alone as well as patients with pregnancy morbidity.
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“We also recently observed that 40 units GPL rather than the 99th percentile is a valid cut-off to identify patients at risk of thrombosis [24].”
From Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome (2010) · cites this paper as [24]
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Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome
PENGO, V., RUFFATTI, A., LEGNANI, C., GRESELE, P., BARCELLONA, D., ERBA, N., TESTA, S., MARONGIU, F., BISON, E., DENAS, G., et al. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03674.x · Cited by 632
Self-citationLaboratory criteria for antiphospholipid syndrome: communication from the SSC of the ISTH
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Testing for Antiphospholipid antibodies with Solid Phase Assays: guidance from the SSC of the ISTH
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Metadata
- Authors
- RUFFATTI, A., OLIVIERI, S., TONELLO, M., BORTOLATI, M., BISON, E., SALVAN, E., FACCHINETTI, M., & PENGO, V.
- Affiliations
- University of Padua (IT)
- Corresponding author
- RUFFATTI, A.
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 6
- Issue
- 10
- Pages
- 1693-1696
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W1977057127
- Cited by
- 134
- References
- 24
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 10 · 2020: 7 · 2019: 9 · 2018: 14 · 2017: 6 · 2016: 12 · 2015: 12 · 2014: 8 · 2013: 6 · 2012: 16
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- antiphospholipid syndrome, anticardiolipin antibodies, IgG, cut-off values, 99th percentile, anti-beta2-glycoprotein I antibodies, lupus anticoagulant, pregnancy morbidity, thrombosis, diagnostic sensitivity
- MeSH terms
- Antibodies, Monoclonal, Female, Humans, Immunoglobulin G, Male, Pregnancy, Pregnancy Complications, Sensitivity and Specificity, Thrombosis, Lupus Coagulation Inhibitor, Antiphospholipid Syndrome, Antibodies, Anticardiolipin, Practice Guidelines as Topic, Clinical Laboratory Techniques, beta 2-Glycoprotein I
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